Dermal fibroblast extracellular matrix regulates keratinocyte behaviour
This project explored using dermal fibroblast-derived extracellular matrices (ECMs) to recapitulate the keratinocyte microenvironmental niche in vitro. The data indicated that fibroblast-derived matrices better supported keratinocytes expansion than substrates of type I collagen. ECM composition was...
| Main Author: | |
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| Format: | Thesis |
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Curtin University
2017
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| Online Access: | http://hdl.handle.net/20.500.11937/68292 |
| _version_ | 1848761366060466176 |
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| author | Wong, Chee Wai |
| author_facet | Wong, Chee Wai |
| author_sort | Wong, Chee Wai |
| building | Curtin Institutional Repository |
| collection | Online Access |
| description | This project explored using dermal fibroblast-derived extracellular matrices (ECMs) to recapitulate the keratinocyte microenvironmental niche in vitro. The data indicated that fibroblast-derived matrices better supported keratinocytes expansion than substrates of type I collagen. ECM composition was found to profoundly alter the gene expression profiles of keratinocytes grown on these matrices, in that foetal matrices triggered expression of cell cycle genes, whereas adult matrices triggered the expression of a balance of differentiation and cell cycle genes. |
| first_indexed | 2025-11-14T10:30:31Z |
| format | Thesis |
| id | curtin-20.500.11937-68292 |
| institution | Curtin University Malaysia |
| institution_category | Local University |
| last_indexed | 2025-11-14T10:30:31Z |
| publishDate | 2017 |
| publisher | Curtin University |
| recordtype | eprints |
| repository_type | Digital Repository |
| spelling | curtin-20.500.11937-682922018-05-25T00:44:56Z Dermal fibroblast extracellular matrix regulates keratinocyte behaviour Wong, Chee Wai This project explored using dermal fibroblast-derived extracellular matrices (ECMs) to recapitulate the keratinocyte microenvironmental niche in vitro. The data indicated that fibroblast-derived matrices better supported keratinocytes expansion than substrates of type I collagen. ECM composition was found to profoundly alter the gene expression profiles of keratinocytes grown on these matrices, in that foetal matrices triggered expression of cell cycle genes, whereas adult matrices triggered the expression of a balance of differentiation and cell cycle genes. 2017 Thesis http://hdl.handle.net/20.500.11937/68292 Curtin University fulltext |
| spellingShingle | Wong, Chee Wai Dermal fibroblast extracellular matrix regulates keratinocyte behaviour |
| title | Dermal fibroblast extracellular matrix regulates keratinocyte behaviour |
| title_full | Dermal fibroblast extracellular matrix regulates keratinocyte behaviour |
| title_fullStr | Dermal fibroblast extracellular matrix regulates keratinocyte behaviour |
| title_full_unstemmed | Dermal fibroblast extracellular matrix regulates keratinocyte behaviour |
| title_short | Dermal fibroblast extracellular matrix regulates keratinocyte behaviour |
| title_sort | dermal fibroblast extracellular matrix regulates keratinocyte behaviour |
| url | http://hdl.handle.net/20.500.11937/68292 |