Impaired thrombin-induced platelet activation and thrombus formation in mice lacking the Ca2+-dependent tyrosine kinase Pyk2

QR Code

Impaired thrombin-induced platelet activation and thrombus formation in mice lacking the Ca2+-dependent tyrosine kinase Pyk2

In the present study, we used a knockout murine model to analyze the contribution of the Ca2+-dependent focal adhesion kinase Pyk2 in platelet activation and thrombus formation in vivo. We found that Pyk2-knockout mice had a tail bleeding time that was slightly increased compared with their wild-typ...

Full description

Bibliographic Details
Main Authors:	Canobbio, I., Cipolla, L., Consonni, A., Momi, S., Guidetti, G., Oliviero, B., Falasca, Marco, Okigaki, M., Balduini, C., Gresele, P., Torti, M.
Format:	Journal Article
Published:	2013
Online Access:	http://hdl.handle.net/20.500.11937/6824

Similar Items

The role of the focal adhesion kinase Pyk2 in platelet activation
by: Cipolla, L., et al.
Published: (2011)

The role of the focal adhesion kinase PYK2 in platelet activation
by: Canobbio, I., et al.
Published: (2011)

The focal adhesion kinase Pyk2 links Ca2+ signalling to Src family kinase activation and protein tyrosine phosphorylation in thrombin-stimulated platelets
by: Canobbio, I., et al.
Published: (2015)

The proline-rich tyrosine kinase Pyk2 regulates platelet integrin aIIbß3 outside-in signaling
by: Cipolla, L., et al.
Published: (2013)

The tyrosine kinase Pyk2 mediates the cross-talk between platelet integrins alpha 2 beta 1 and alpha IIb beta 3
by: Guidetti, G., et al.
Published: (2011)

The tyrosine kinase PYK2 mediates the cross-talk between platelet integrins alpha 2 beta 1 and alpha iib beta 3
by: Guidetti, G., et al.
Published: (2011)

Activation of phosphatidylinositol 3-kinase ß by the platelet collagen receptors integrin a2ß1 and GPVI: The role of Pyk2 and c-Cbl
by: Manganaro, D., et al.
Published: (2015)

Role and regulation of phosphatidylinositol 3-kinase ß in platelet integrin α2ß1 signaling
by: Consonni, A., et al.
Published: (2012)

PYK2 is prerequisite for GPVI-induced platelet ROS production, but not aggregation
by: Walsh, T., et al.
Published: (2011)

Role of Focal Adhesion Tyrosine Kinases in GPVI-Dependent Platelet Activation and Reactive Oxygen Species Formation
by: Carrim, N., et al.
Published: (2014)

The role of Nox1 and Nox2 in GPVI-dependent platelet activation and thrombus formation
by: Walsh, T., et al.
Published: (2014)

The role of NADPH oxidase (NOX) 1 and 2 in GPVI-dependent platelet activation and thrombus formation
by: Walsh, T., et al.
Published: (2013)

Cadherin 6 has a functional role in platelet aggregation and thrombus formation
by: Dunne, E., et al.
Published: (2012)

A balance between TFPI and thrombin-mediated platelet activation is required for murine embryonic development
by: Ellery, Paul, et al.
Published: (2015)

COMP: An endogenous thrombin inhibitor
by: Metharom, P., et al.
Published: (2015)

New direction for WE thrombin
by: Berndt, Michael, et al.
Published: (2008)

Mathematical models of thrombin generation
by: Owen, Matt J
Published: (2023)

Thrombin-induced reactive oxygen species generation in platelets: A novel role for protease-activated receptor 4 and GPIba.
by: Carrim, N., et al.
Published: (2015)

Editorial: Platelet hem-Immunoreceptor Tyrosine-Based Activation Motif Receptors: At Lease One Required
by: Berndt, Michael, et al.
Published: (2013)

Anterior penetrating chest injury with left ventricular thrombus.
by: Ruth Sabrina S,, et al.
Published: (2013)

Some Biochemical Aspects Of Tyrosine Aminotransferase (L-Tyrosine: 2-Oxoglutarate Aminotransferase, E.C. 2.6.1.5) (TAT) In The Stages Of Development Of Aedes Aegypti Linnaeu
by: Chan, Guat Lian
Published: (1976)

Src family tyrosine kinase Lyn mediates VWF GPIb-IX induced platelet activation via the cGMP signaling pathway
by: Yin, H., et al.
Published: (2008)

Mice Lacking the ITIM-Containing Receptor G6b-B Exhibit Macrothrombocytopenia andAberrant Platelet Function
by: Mazharian, A., et al.
Published: (2012)

Targeting platelets for the treatment of cancer
by: Elaskalani, Omar, et al.
Published: (2017)

The platelet receptor CLEC-2 is active as a dimer
by: Watson, A., et al.
Published: (2009)

Comparison of platelet function and platelet parameters of apheresis platelet using platelet additive solution and without platelet additive solution
by: Adzahar, Sumaiyah
Published: (2021)

Outcomes of thrombus aspiration during primary percutaneous coronary intervention for ST-elevation myocardial infarction
by: Rajakariar, K., et al.
Published: (2023)

Inherited anti-thrombin deficiency in a Malay-Malaysian family: a missense mutation at nucleotide g.13267C>A aka anti-thrombin Budapest 5 (p.Pro439Thr) of the SERPINC 1 gene
by: A.Talib, Norlelawati, et al.
Published: (2014)

Endovascular thrombectomy (EVT) of an atherosclerotic plaque masquerading as thrombus in a large vessel occlusion (LVO) stroke
by: Muda, Ahmad Sobri, et al.
Published: (2023)

Ser70 phosphorylation of Bcl-2 by selective tyrosine nitration of PP2A-B56 d stabilizes its antiapoptotic activity
by: Low, I., et al.
Published: (2014)

Grads lack required skills
Published: (2008)

Strong interest but lacking funds
Published: (2008)

Intra-luminal thrombus bleeding in abdominal aortic aneurysm as an indicator for acute or impending rupture: a case series
by: Abdul Rahman, Mohd Norhisham Azmi, et al.
Published: (2016)

Intra-luminal thrombus bleeding in abdominal aortic aneurysm as an indicator for acute or impending rupture: A case series
by: Abdul Rahman, Mohd Norhisham Azmi, et al.
Published: (2016)

Self-assembling tyrosine kinase inhibitors for localised targeted delivery
by: Al-Ameedee, Mohammed
Published: (2017)

Molecular Docking Of Andrographolide To Rennin, HIV-Protease And Tyrosine Enzymes.
by: Kamaluddin, Achsanuddin, et al.
Published: (2003)

D-amphetamine and antipsychotic drug effects on latent inhibition in mice lacking dopamine D2 receptors
by: Bay-Richter, C., et al.
Published: (2013)

Virtual Screening Of Protein Tyrosine Phosphatase 1b In Search For Natural Products With Potential Activity Againts Diabetes Mellitus Type 2
by: Ho, Yueng Hsing
Published: (2018)

Lack of association between the MDM2 promoter polymorphism SNP309 and clinical outcome in chronic lymphocytic leukimia
by: Kaderi, Mohd Arifin, et al.
Published: (2010)

An apoferritin-based drug delivery system for the tyrosine kinase inhibitor gefitinib
by: Kuruppu, Anchala I., et al.
Published: (2015)

Cannot write session to /tmp/vufind_sessions/sess_aj5agoa241h69r9nkhhpj68hhr