A new microwave-assisted, three-component reaction of 5-aminopyrazole-4-carboxylates: Selective synthesis of substituted 5-aza-9-deaza-adenines
© 2018 Elsevier Ltd A series of 5-aza-9-deaza- analogues of purine was effectively prepared using highly selective annulation of 1,3,5-triazine ring onto 5-aminopyrazole-4-carboxylates via a one-pot, multicomponent, microwave-assisted approach. The products were obtained in good yields and high pur...
| Main Authors: | , , , |
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| Format: | Journal Article |
| Published: |
Pergamon-Elsevier Science Ltd
2018
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| Online Access: | http://hdl.handle.net/20.500.11937/68154 |
| _version_ | 1848761756998959104 |
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| author | Lim, F. Halcovitch, N. Tiekink, E. Dolzhenko, Anton |
| author_facet | Lim, F. Halcovitch, N. Tiekink, E. Dolzhenko, Anton |
| author_sort | Lim, F. |
| building | Curtin Institutional Repository |
| collection | Online Access |
| description | © 2018 Elsevier Ltd A series of 5-aza-9-deaza- analogues of purine was effectively prepared using highly selective annulation of 1,3,5-triazine ring onto 5-aminopyrazole-4-carboxylates via a one-pot, multicomponent, microwave-assisted approach. The products were obtained in good yields and high purity. This catalyst-free method was demonstrated to be scalable and highly reproducible in different microwave reactors. Some structural features of the prepared compounds were studied in details using dynamic NMR spectroscopy and X-ray crystallography. |
| first_indexed | 2025-11-14T10:36:44Z |
| format | Journal Article |
| id | curtin-20.500.11937-68154 |
| institution | Curtin University Malaysia |
| institution_category | Local University |
| last_indexed | 2025-11-14T10:36:44Z |
| publishDate | 2018 |
| publisher | Pergamon-Elsevier Science Ltd |
| recordtype | eprints |
| repository_type | Digital Repository |
| spelling | curtin-20.500.11937-681542018-05-18T08:07:30Z A new microwave-assisted, three-component reaction of 5-aminopyrazole-4-carboxylates: Selective synthesis of substituted 5-aza-9-deaza-adenines Lim, F. Halcovitch, N. Tiekink, E. Dolzhenko, Anton © 2018 Elsevier Ltd A series of 5-aza-9-deaza- analogues of purine was effectively prepared using highly selective annulation of 1,3,5-triazine ring onto 5-aminopyrazole-4-carboxylates via a one-pot, multicomponent, microwave-assisted approach. The products were obtained in good yields and high purity. This catalyst-free method was demonstrated to be scalable and highly reproducible in different microwave reactors. Some structural features of the prepared compounds were studied in details using dynamic NMR spectroscopy and X-ray crystallography. 2018 Journal Article http://hdl.handle.net/20.500.11937/68154 10.1016/j.tet.2018.02.054 Pergamon-Elsevier Science Ltd restricted |
| spellingShingle | Lim, F. Halcovitch, N. Tiekink, E. Dolzhenko, Anton A new microwave-assisted, three-component reaction of 5-aminopyrazole-4-carboxylates: Selective synthesis of substituted 5-aza-9-deaza-adenines |
| title | A new microwave-assisted, three-component reaction of 5-aminopyrazole-4-carboxylates: Selective synthesis of substituted 5-aza-9-deaza-adenines |
| title_full | A new microwave-assisted, three-component reaction of 5-aminopyrazole-4-carboxylates: Selective synthesis of substituted 5-aza-9-deaza-adenines |
| title_fullStr | A new microwave-assisted, three-component reaction of 5-aminopyrazole-4-carboxylates: Selective synthesis of substituted 5-aza-9-deaza-adenines |
| title_full_unstemmed | A new microwave-assisted, three-component reaction of 5-aminopyrazole-4-carboxylates: Selective synthesis of substituted 5-aza-9-deaza-adenines |
| title_short | A new microwave-assisted, three-component reaction of 5-aminopyrazole-4-carboxylates: Selective synthesis of substituted 5-aza-9-deaza-adenines |
| title_sort | new microwave-assisted, three-component reaction of 5-aminopyrazole-4-carboxylates: selective synthesis of substituted 5-aza-9-deaza-adenines |
| url | http://hdl.handle.net/20.500.11937/68154 |