Predictors of mean arterial pressure morning rate of rise and power function in subjects undergoing ambulatory blood pressure recording
Background: We determined clinical predictors of the rate of rise (RoR) in blood pressure in the morning as well as a novel measure of the power of the BP surge (BPpower) derived from ambulatory blood pressure recordings. Methods: BPpower and RoR were calculated from 409 ambulatory blood pressure (A...
| Main Authors: | , , , , , , , , |
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| Format: | Journal Article |
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Public Library of Science
2014
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| Online Access: | http://hdl.handle.net/20.500.11937/6814 |
| _version_ | 1848745185197948928 |
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| author | Head, G. Andrianopoulos, N. McGrath, B. Martin, C. Carrington, M. Lukoshkova, E. Davern, P. Jennings, G. Reid, Christopher |
| author_facet | Head, G. Andrianopoulos, N. McGrath, B. Martin, C. Carrington, M. Lukoshkova, E. Davern, P. Jennings, G. Reid, Christopher |
| author_sort | Head, G. |
| building | Curtin Institutional Repository |
| collection | Online Access |
| description | Background: We determined clinical predictors of the rate of rise (RoR) in blood pressure in the morning as well as a novel measure of the power of the BP surge (BPpower) derived from ambulatory blood pressure recordings. Methods: BPpower and RoR were calculated from 409 ambulatory blood pressure (ABP) recordings from subjects attending a cardiovascular risk clinic. Anthropometric data, blood biochemistry, and history were recorded. The 409 subjects were 20-82 years old (average 57, SD = 13), 46% male, 9% with hypertension but not on medication and 34% on antihypertensive medication. Results: Average RoR was 11.1 mmHg/hour (SD = 8) and BPpower was 273 mmHg2/hour (SD = 235). Only cholesterol, low density lipoprotein and body mass index (BMI) were associated with higher BPpower and RoR (P<0.05) from 25 variables assessed. BPpower was lower in those taking beta-blockers or diuretics. Multivariate analysis identified that only BMI was associated with RoR (4.2% increase/unit BMI, P = 0.020) while cholesterol was the only remaining associated variable with BPpower (17.5% increase/mmol/L cholesterol, P = 0.047). A follow up of 213 subjects with repeated ABP after an average 1.8 years identified that baseline cholesterol was the only predictor for an increasing RoR and BPpower (P<0.05). 37 patients who commenced statin subsequently had lower BPpower whereas 90 age and weight matched controls had similar BPpower on follow-up. Conclusions: Cholesterol is an independent predictor of a greater and more rapid rise in morning BP as well as of further increases over several years. Reduction of cholesterol with statin therapy is very effective in reducing the morning blood pressure surge. © 2014 Head et al. |
| first_indexed | 2025-11-14T06:13:20Z |
| format | Journal Article |
| id | curtin-20.500.11937-6814 |
| institution | Curtin University Malaysia |
| institution_category | Local University |
| last_indexed | 2025-11-14T06:13:20Z |
| publishDate | 2014 |
| publisher | Public Library of Science |
| recordtype | eprints |
| repository_type | Digital Repository |
| spelling | curtin-20.500.11937-68142017-09-13T14:34:28Z Predictors of mean arterial pressure morning rate of rise and power function in subjects undergoing ambulatory blood pressure recording Head, G. Andrianopoulos, N. McGrath, B. Martin, C. Carrington, M. Lukoshkova, E. Davern, P. Jennings, G. Reid, Christopher Background: We determined clinical predictors of the rate of rise (RoR) in blood pressure in the morning as well as a novel measure of the power of the BP surge (BPpower) derived from ambulatory blood pressure recordings. Methods: BPpower and RoR were calculated from 409 ambulatory blood pressure (ABP) recordings from subjects attending a cardiovascular risk clinic. Anthropometric data, blood biochemistry, and history were recorded. The 409 subjects were 20-82 years old (average 57, SD = 13), 46% male, 9% with hypertension but not on medication and 34% on antihypertensive medication. Results: Average RoR was 11.1 mmHg/hour (SD = 8) and BPpower was 273 mmHg2/hour (SD = 235). Only cholesterol, low density lipoprotein and body mass index (BMI) were associated with higher BPpower and RoR (P<0.05) from 25 variables assessed. BPpower was lower in those taking beta-blockers or diuretics. Multivariate analysis identified that only BMI was associated with RoR (4.2% increase/unit BMI, P = 0.020) while cholesterol was the only remaining associated variable with BPpower (17.5% increase/mmol/L cholesterol, P = 0.047). A follow up of 213 subjects with repeated ABP after an average 1.8 years identified that baseline cholesterol was the only predictor for an increasing RoR and BPpower (P<0.05). 37 patients who commenced statin subsequently had lower BPpower whereas 90 age and weight matched controls had similar BPpower on follow-up. Conclusions: Cholesterol is an independent predictor of a greater and more rapid rise in morning BP as well as of further increases over several years. Reduction of cholesterol with statin therapy is very effective in reducing the morning blood pressure surge. © 2014 Head et al. 2014 Journal Article http://hdl.handle.net/20.500.11937/6814 10.1371/journal.pone.0093186 Public Library of Science unknown |
| spellingShingle | Head, G. Andrianopoulos, N. McGrath, B. Martin, C. Carrington, M. Lukoshkova, E. Davern, P. Jennings, G. Reid, Christopher Predictors of mean arterial pressure morning rate of rise and power function in subjects undergoing ambulatory blood pressure recording |
| title | Predictors of mean arterial pressure morning rate of rise and power function in subjects undergoing ambulatory blood pressure recording |
| title_full | Predictors of mean arterial pressure morning rate of rise and power function in subjects undergoing ambulatory blood pressure recording |
| title_fullStr | Predictors of mean arterial pressure morning rate of rise and power function in subjects undergoing ambulatory blood pressure recording |
| title_full_unstemmed | Predictors of mean arterial pressure morning rate of rise and power function in subjects undergoing ambulatory blood pressure recording |
| title_short | Predictors of mean arterial pressure morning rate of rise and power function in subjects undergoing ambulatory blood pressure recording |
| title_sort | predictors of mean arterial pressure morning rate of rise and power function in subjects undergoing ambulatory blood pressure recording |
| url | http://hdl.handle.net/20.500.11937/6814 |