Conceptual design and simulation of a plant for the production of high purity (S)-ibuprofen acid using innovative enzymatic membrane technology
(S)-Ibuprofen is a low volume but high value pharmaceutical product which is categorized as non-steroidal anti-inflammatory drug (NSAID). This precious chiral drug may be produced using racemic ibuprofen as raw material through the dynamic kinetic resolution. In this work, a simulation of (S)-ibupro...
| Main Authors: | , , , , |
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| Format: | Journal Article |
| Published: |
Elsevier BV
2011
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| Online Access: | http://hdl.handle.net/20.500.11937/68117 |
| _version_ | 1848761747530317824 |
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| author | Lau, John Gonawan, F. Bhatia, S. Kamaruddin, A. Uzir, M. |
| author_facet | Lau, John Gonawan, F. Bhatia, S. Kamaruddin, A. Uzir, M. |
| author_sort | Lau, John |
| building | Curtin Institutional Repository |
| collection | Online Access |
| description | (S)-Ibuprofen is a low volume but high value pharmaceutical product which is categorized as non-steroidal anti-inflammatory drug (NSAID). This precious chiral drug may be produced using racemic ibuprofen as raw material through the dynamic kinetic resolution. In this work, a simulation of (S)-ibuprofen production is carried out using ASPEN PLUS ® process simulation software. A pilot scale production with the capacity of 500g/day of (S)-ibuprofen acid is considered in the present study. The product is synthesized through a three-step process: (i) substrate preparation via esterification; (ii) enzymatic dynamic kinetic resolution of substrate ester and (iii) product purification. Mass and energy balances of major equipment were calculated. The performance of the enzyme-mediated membrane reactor (EMR) was investigated by manipulating substrate and base concentrations as well as the flow rates. Besides, a number of issues related to the evaporation and crystallization of the product were identified and addressed. It was found that the optimum operating condition of EMR at 40°C, 50-100ml/min lumen flow rate with substrate and base concentrations, respectively at 10-20mM and 60-100mM, gave 0.92 conversion and 0.9 ee p of the product. An overall yield of 82.5% product crystal was achieved by operating the cooling-crystallizer in the temperature range of 5-10°C. © 2010 Elsevier B.V. |
| first_indexed | 2025-11-14T10:36:35Z |
| format | Journal Article |
| id | curtin-20.500.11937-68117 |
| institution | Curtin University Malaysia |
| institution_category | Local University |
| last_indexed | 2025-11-14T10:36:35Z |
| publishDate | 2011 |
| publisher | Elsevier BV |
| recordtype | eprints |
| repository_type | Digital Repository |
| spelling | curtin-20.500.11937-681172018-05-18T08:07:30Z Conceptual design and simulation of a plant for the production of high purity (S)-ibuprofen acid using innovative enzymatic membrane technology Lau, John Gonawan, F. Bhatia, S. Kamaruddin, A. Uzir, M. (S)-Ibuprofen is a low volume but high value pharmaceutical product which is categorized as non-steroidal anti-inflammatory drug (NSAID). This precious chiral drug may be produced using racemic ibuprofen as raw material through the dynamic kinetic resolution. In this work, a simulation of (S)-ibuprofen production is carried out using ASPEN PLUS ® process simulation software. A pilot scale production with the capacity of 500g/day of (S)-ibuprofen acid is considered in the present study. The product is synthesized through a three-step process: (i) substrate preparation via esterification; (ii) enzymatic dynamic kinetic resolution of substrate ester and (iii) product purification. Mass and energy balances of major equipment were calculated. The performance of the enzyme-mediated membrane reactor (EMR) was investigated by manipulating substrate and base concentrations as well as the flow rates. Besides, a number of issues related to the evaporation and crystallization of the product were identified and addressed. It was found that the optimum operating condition of EMR at 40°C, 50-100ml/min lumen flow rate with substrate and base concentrations, respectively at 10-20mM and 60-100mM, gave 0.92 conversion and 0.9 ee p of the product. An overall yield of 82.5% product crystal was achieved by operating the cooling-crystallizer in the temperature range of 5-10°C. © 2010 Elsevier B.V. 2011 Journal Article http://hdl.handle.net/20.500.11937/68117 10.1016/j.cej.2010.11.072 Elsevier BV restricted |
| spellingShingle | Lau, John Gonawan, F. Bhatia, S. Kamaruddin, A. Uzir, M. Conceptual design and simulation of a plant for the production of high purity (S)-ibuprofen acid using innovative enzymatic membrane technology |
| title | Conceptual design and simulation of a plant for the production of high purity (S)-ibuprofen acid using innovative enzymatic membrane technology |
| title_full | Conceptual design and simulation of a plant for the production of high purity (S)-ibuprofen acid using innovative enzymatic membrane technology |
| title_fullStr | Conceptual design and simulation of a plant for the production of high purity (S)-ibuprofen acid using innovative enzymatic membrane technology |
| title_full_unstemmed | Conceptual design and simulation of a plant for the production of high purity (S)-ibuprofen acid using innovative enzymatic membrane technology |
| title_short | Conceptual design and simulation of a plant for the production of high purity (S)-ibuprofen acid using innovative enzymatic membrane technology |
| title_sort | conceptual design and simulation of a plant for the production of high purity (s)-ibuprofen acid using innovative enzymatic membrane technology |
| url | http://hdl.handle.net/20.500.11937/68117 |