Aged neutrophils accumulate in lymphoid tissues from healthy elderly mice and infiltrate T- and B-cell zones
The average age of the human population is rising, leading to an increasing burden of age-related diseases, including increased susceptibility to infection. However, immune function can decrease with age which could impact on processes that require a functional immune system. Aging is also character...
| Main Authors: | Tomay, F., Wells, K., Duong, L., Tsu, J., Dye, D., Crabb, Hannah, Grounds, M., Shavlakadze, T., Metharom, Pat, Nelson, Delia, Jackaman, Connie |
|---|---|
| Format: | Journal Article |
| Published: |
Nature Publishing Group
2018
|
| Online Access: | http://hdl.handle.net/20.500.11937/68007 |
Similar Items
Aging and cancer: The role of macrophages and neutrophils
by: Jackaman, Connie, et al.
Published: (2017)
by: Jackaman, Connie, et al.
Published: (2017)
Targeting macrophages rescues age-related immune deficiencies in C57BL/6J geriatric mice
by: Jackaman, Connie, et al.
Published: (2013)
by: Jackaman, Connie, et al.
Published: (2013)
Macrophage Depletion in Elderly Mice Improves Response to Tumor Immunotherapy, Increases Anti-tumor T Cell Activity and Reduces Treatment-Induced Cachexia
by: Duong, L., et al.
Published: (2018)
by: Duong, L., et al.
Published: (2018)
Are macrophages, myeloid derived suppressor cells and neutrophils mediators of local suppression in healthy and cancerous tissues in aging hosts?
by: Jackaman, Connie, et al.
Published: (2013)
by: Jackaman, Connie, et al.
Published: (2013)
Targeting macrophages rescues age and tumor-induced T cell dysfunction in elderly mice
by: Jackaman, Connie, et al.
Published: (2016)
by: Jackaman, Connie, et al.
Published: (2016)
IL-2/CD40-activated macrophages rescue age and tumor-induced T cell dysfunction in elderly mice
by: Jackaman, Connie, et al.
Published: (2014)
by: Jackaman, Connie, et al.
Published: (2014)
Lipid-laden partially-activated plasmacytoid and CD4-CD8a+ dendritic cells accumulate in tissues in elderly mice
by: Gardner, Joanne, et al.
Published: (2014)
by: Gardner, Joanne, et al.
Published: (2014)
CD8+ cytotoxic T cell responses to dominant tumor-associated antigens are profoundly weakened by aging yet subdominant responses retain functionality and expand in response to chemotherapy
by: Jackaman, Connie, et al.
Published: (2019)
by: Jackaman, Connie, et al.
Published: (2019)
Lipid Accumulation in Dysferlin-Deficient Muscles
by: Grounds, M., et al.
Published: (2014)
by: Grounds, M., et al.
Published: (2014)
Despite generating a weak tumour-specific CTL response during tumour progression chemotherapy is only effective in elderly mice if T cells are present
by: Nelson, D., et al.
Published: (2016)
by: Nelson, D., et al.
Published: (2016)
Effects of loaded voluntary wheel exercise on performance and muscle hypertrophy in young and old male C57Bl/6J mice
by: Soffe, Z., et al.
Published: (2016)
by: Soffe, Z., et al.
Published: (2016)
Molecular analyses provide insight into mechanisms underlying sarcopenia and myofibre denervation in old skeletal muscles of mice
by: Barns, M., et al.
Published: (2014)
by: Barns, M., et al.
Published: (2014)
A single 30 min treadmill exercise session is suitable for 'proof-of-concept studies' in adult mdx mice: A comparison of the early consequences of two different treadmill protocols.
by: Crabb, Hannah, et al.
Published: (2012)
by: Crabb, Hannah, et al.
Published: (2012)
Rapid copper acquisition by developing murine mesothelioma: Decreasing bioavailable copper slows tumor growth, normalizes vessels and promotes T cell infiltration
by: Crowe, Andrew, et al.
Published: (2013)
by: Crowe, Andrew, et al.
Published: (2013)
The different impact of a high fat diet on dystrophic mdx and control C57Bl/10 mice
by: Crabb, Hannah, et al.
Published: (2011)
by: Crabb, Hannah, et al.
Published: (2011)
Intratumoral interleukin-2/agonist CD40 antibody drives CD4+ - independent resolution of treated-turmors and CD4+ -dependent systemic and memory responses
by: Jackaman, Connie, et al.
Published: (2012)
by: Jackaman, Connie, et al.
Published: (2012)
Intratumoral interleukin-2/agonist CD40 antibody drives CD4+-independent resolution of treated-tumors and CD4+-dependent systemic and memory responses
by: Jackaman, Connie, et al.
Published: (2012)
by: Jackaman, Connie, et al.
Published: (2012)
Extracellular DNA and histones are dispensable for neutrophil extracellular trap-induced aggregation of human washed platelets
by: Elaskalani, O., et al.
Published: (2018)
by: Elaskalani, O., et al.
Published: (2018)
Pancreatic cancer-induced neutrophil extracellular traps: A potential contributor to cancer-associated thrombosis
by: Razak, N., et al.
Published: (2017)
by: Razak, N., et al.
Published: (2017)
Neutrophil extracellular traps induce aggregation of washed human platelets independently of extracellular DNA and histones
by: Elaskalani, O., et al.
Published: (2018)
by: Elaskalani, O., et al.
Published: (2018)
Identification of muscle necrosis in the mdx mouse model of Duchenne muscular dystrophy using three - dimensional optical coherence tomography
by: Klyen, B., et al.
Published: (2011)
by: Klyen, B., et al.
Published: (2011)
N-Acetylcysteine treatment of dystrophic mdx mice results in protein thiol modifications and inhibition of exercise induced myofibre necrosis
by: Terrill, J., et al.
Published: (2012)
by: Terrill, J., et al.
Published: (2012)
Observations on the gross changes in the secondary lymphoid organs of mice infected with Nematospiroides dubius
by: Ali, Najah M.H., et al.
Published: (1985)
by: Ali, Najah M.H., et al.
Published: (1985)
In vivo models of lung neutrophil activation. Comparison of mice and hamsters
by: Corteling, R., et al.
Published: (2002)
by: Corteling, R., et al.
Published: (2002)
Lifelong exercise and locally produced insulin-like growth factor-1 (IGF-1) have a modest influence on reducing age-related muscle wasting in mice
by: McMahon, C., et al.
Published: (2014)
by: McMahon, C., et al.
Published: (2014)
Ultrastructural evaluation of bronchial lymphoid aggregates and lymphoid nodules in calves at different ages
by: Abu Bakar @ Zakaria, Md Zuki, et al.
Published: (2009)
by: Abu Bakar @ Zakaria, Md Zuki, et al.
Published: (2009)
Blockade of TNF in vivo using cV1q antibody reduces contractile dysfunction of skeletal muscle in response to eccentric exercise in dystrophic mdx and normal mice
by: Piers, A., et al.
Published: (2011)
by: Piers, A., et al.
Published: (2011)
CD40-activated B cells contribute to mesothelioma tumor regression
by: Jackaman, Connie, et al.
Published: (2011)
by: Jackaman, Connie, et al.
Published: (2011)
The Regulatory Status Adopted by Lymph Node Dendritic Cells and T Cells During Healthy Aging Is Maintained During Cancer and May Contribute to Reduced Responses to Immunotherapy
by: Gardner, J., et al.
Published: (2018)
by: Gardner, J., et al.
Published: (2018)
Modulation of dendritic cell and T cell cross-talk during aging: The potential role of checkpoint inhibitory molecules
by: Gardner, J., et al.
Published: (2017)
by: Gardner, J., et al.
Published: (2017)
Targeting the ubiquitin pathway in lymphoid malignancies
by: Li, Boheng, et al.
Published: (2024)
by: Li, Boheng, et al.
Published: (2024)
IL-2/CD40-driven NK cells install and maintain potency in the anti-mesothelioma effector/memory phase
by: Jackaman, Connie, et al.
Published: (2012)
by: Jackaman, Connie, et al.
Published: (2012)
Murine mesothelioma induces locally-proliferating IL-10+TNF-a+CD206-CX3CR1+ M3 macrophages that can be selectively depleted by chemotherapy or immunotherapy
by: Jackaman, Connie, et al.
Published: (2016)
by: Jackaman, Connie, et al.
Published: (2016)
Chemotherapy broadens the range of tumor antigens seen by cytotoxic CD8+ T cells in vivo
by: Jackaman, Connie, et al.
Published: (2012)
by: Jackaman, Connie, et al.
Published: (2012)
Sarcostemma viminale activates macrophages to a pro-inflammatory phenotype
by: Brestovac, Brian, et al.
Published: (2014)
by: Brestovac, Brian, et al.
Published: (2014)
The characterisation of the uptake of microparticulates across intestinal lymphoid tissue
by: Howard, Kenneth Alan
Published: (1994)
by: Howard, Kenneth Alan
Published: (1994)
Histomorphology of the lymphoid tissues of broiler
chickens in Kelantan, Malaysia
by: Mohd Zahirul Islam Khan,, et al.
Published: (2014)
by: Mohd Zahirul Islam Khan,, et al.
Published: (2014)
A Neurogenic Perspective of Sarcopenia: Time Course Study of Sciatic Nerves From Aging Mice
by: Krishnan, V., et al.
Published: (2016)
by: Krishnan, V., et al.
Published: (2016)
Mesothelioma tumor cells modulate dendritic cell lipid content, phenotype and function
by: Gardner, J., et al.
Published: (2015)
by: Gardner, J., et al.
Published: (2015)
Resistance wheel exercise from mid-life has minimal effect on sciatic nerves from old mice in which sarcopenia was prevented
by: Krishnan, V., et al.
Published: (2017)
by: Krishnan, V., et al.
Published: (2017)
Similar Items
-
Aging and cancer: The role of macrophages and neutrophils
by: Jackaman, Connie, et al.
Published: (2017) -
Targeting macrophages rescues age-related immune deficiencies in C57BL/6J geriatric mice
by: Jackaman, Connie, et al.
Published: (2013) -
Macrophage Depletion in Elderly Mice Improves Response to Tumor Immunotherapy, Increases Anti-tumor T Cell Activity and Reduces Treatment-Induced Cachexia
by: Duong, L., et al.
Published: (2018) -
Are macrophages, myeloid derived suppressor cells and neutrophils mediators of local suppression in healthy and cancerous tissues in aging hosts?
by: Jackaman, Connie, et al.
Published: (2013) -
Targeting macrophages rescues age and tumor-induced T cell dysfunction in elderly mice
by: Jackaman, Connie, et al.
Published: (2016)