Taste evaluation of a novel midazolam tablet for pediatric patients: In vitro drug dissolution, in vivo animal taste aversion and clinical taste perception profiles

Taste evaluation of a novel midazolam tablet for pediatric patients: In vitro drug dissolution, in vivo animal taste aversion and clinical taste perception profiles

© 2017 Elsevier B.V. Harmonized methodologies are urgently required for the taste evaluation of novel pediatric medicines. This study utilized in vitro, in vivo and clinical data to evaluate the palatability of a novel midazolam chocolate tablet. In vitro dissolution experiments showed the crushed...

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Bibliographic Details
Main Authors: Cheung, Laurence, Nguyen, M., Tang, E., von Ungern Sternberg, B., Salman, S., Tuleu, C., Mohamed Ahmed, A., Soto, J., Lim, L.
Format: Journal Article
Published: Elsevier BV 2018
Online Access:http://hdl.handle.net/20.500.11937/67975

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