Granulosa cell apoptosis in the ovarian follicle-A changing view
Recent studies challenge the previous view that apoptosis within the granulosa cells of the maturing ovarian follicle is a reflection of aging and consequently a marker for poor quality of the contained oocyte. On the contrary, apoptosis within the granulosa cells is an integral part of normal devel...
| Main Authors: | , , , , , |
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| Format: | Journal Article |
| Published: |
Frontiers Research Foundation
2018
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| Online Access: | http://hdl.handle.net/20.500.11937/67965 |
| _version_ | 1848761705351348224 |
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| author | Regan, S. Knight, P. Yovich, John Leung, Y. Arfuso, Frank Dharmarajan, Arunasalam |
| author_facet | Regan, S. Knight, P. Yovich, John Leung, Y. Arfuso, Frank Dharmarajan, Arunasalam |
| author_sort | Regan, S. |
| building | Curtin Institutional Repository |
| collection | Online Access |
| description | Recent studies challenge the previous view that apoptosis within the granulosa cells of the maturing ovarian follicle is a reflection of aging and consequently a marker for poor quality of the contained oocyte. On the contrary, apoptosis within the granulosa cells is an integral part of normal development and has limited predictive capability regarding oocyte quality or the ensuing pregnancy rate in in vitro fertilization programs. This review article covers our revised understanding of the process of apoptosis within the ovarian follicle, its three phenotypes, the major signaling pathways underlying apoptosis as well as the associated mitochondrial pathways. |
| first_indexed | 2025-11-14T10:35:55Z |
| format | Journal Article |
| id | curtin-20.500.11937-67965 |
| institution | Curtin University Malaysia |
| institution_category | Local University |
| last_indexed | 2025-11-14T10:35:55Z |
| publishDate | 2018 |
| publisher | Frontiers Research Foundation |
| recordtype | eprints |
| repository_type | Digital Repository |
| spelling | curtin-20.500.11937-679652018-07-13T03:30:09Z Granulosa cell apoptosis in the ovarian follicle-A changing view Regan, S. Knight, P. Yovich, John Leung, Y. Arfuso, Frank Dharmarajan, Arunasalam Recent studies challenge the previous view that apoptosis within the granulosa cells of the maturing ovarian follicle is a reflection of aging and consequently a marker for poor quality of the contained oocyte. On the contrary, apoptosis within the granulosa cells is an integral part of normal development and has limited predictive capability regarding oocyte quality or the ensuing pregnancy rate in in vitro fertilization programs. This review article covers our revised understanding of the process of apoptosis within the ovarian follicle, its three phenotypes, the major signaling pathways underlying apoptosis as well as the associated mitochondrial pathways. 2018 Journal Article http://hdl.handle.net/20.500.11937/67965 10.3389/fendo.2018.00061 http://creativecommons.org/licenses/by/4.0/ Frontiers Research Foundation fulltext |
| spellingShingle | Regan, S. Knight, P. Yovich, John Leung, Y. Arfuso, Frank Dharmarajan, Arunasalam Granulosa cell apoptosis in the ovarian follicle-A changing view |
| title | Granulosa cell apoptosis in the ovarian follicle-A changing view |
| title_full | Granulosa cell apoptosis in the ovarian follicle-A changing view |
| title_fullStr | Granulosa cell apoptosis in the ovarian follicle-A changing view |
| title_full_unstemmed | Granulosa cell apoptosis in the ovarian follicle-A changing view |
| title_short | Granulosa cell apoptosis in the ovarian follicle-A changing view |
| title_sort | granulosa cell apoptosis in the ovarian follicle-a changing view |
| url | http://hdl.handle.net/20.500.11937/67965 |