Polyclonal emergence of vanA vancomycin-resistant Enterococcus faecium in Australia
Objectives: To investigate the genetic context associated with the emergence of vanA VRE in Australia. Methods: The whole genomes of 18 randomly selected vanA-positive Enterococcus faecium patient isolates, collected between 2011 and 2013 from hospitals in four Australian capitals, were sequenced an...
| Main Authors: | , , , , , , , |
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| Format: | Journal Article |
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Oxford University Press
2017
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| Online Access: | http://hdl.handle.net/20.500.11937/67550 |
| _version_ | 1848761594924761088 |
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| author | van Hal, S. Espedido, B. Coombs, Geoffrey Howden, B. Korman, T. Nimmo, G. Gosbell, I. Jensen, S. |
| author_facet | van Hal, S. Espedido, B. Coombs, Geoffrey Howden, B. Korman, T. Nimmo, G. Gosbell, I. Jensen, S. |
| author_sort | van Hal, S. |
| building | Curtin Institutional Repository |
| collection | Online Access |
| description | Objectives: To investigate the genetic context associated with the emergence of vanA VRE in Australia. Methods: The whole genomes of 18 randomly selected vanA-positive Enterococcus faecium patient isolates, collected between 2011 and 2013 from hospitals in four Australian capitals, were sequenced and analysed. Results: In silico typing and transposon/plasmid assembly revealed that the sequenced isolates represented (in most cases) different hospital-adapted STs and were associated with a variety of different Tn1546 variants and plasmid backbone structures. Conclusions: The recent emergence of vanA VRE in Australia was polyclonal and not associatedwith the dissemination of a single 'dominant' ST or vanA-encoding plasmid. Interestingly, the factors contributing to this epidemiological change are not known and future studies may need to consider investigation of potential community sources. |
| first_indexed | 2025-11-14T10:34:10Z |
| format | Journal Article |
| id | curtin-20.500.11937-67550 |
| institution | Curtin University Malaysia |
| institution_category | Local University |
| last_indexed | 2025-11-14T10:34:10Z |
| publishDate | 2017 |
| publisher | Oxford University Press |
| recordtype | eprints |
| repository_type | Digital Repository |
| spelling | curtin-20.500.11937-675502018-09-26T01:01:33Z Polyclonal emergence of vanA vancomycin-resistant Enterococcus faecium in Australia van Hal, S. Espedido, B. Coombs, Geoffrey Howden, B. Korman, T. Nimmo, G. Gosbell, I. Jensen, S. Objectives: To investigate the genetic context associated with the emergence of vanA VRE in Australia. Methods: The whole genomes of 18 randomly selected vanA-positive Enterococcus faecium patient isolates, collected between 2011 and 2013 from hospitals in four Australian capitals, were sequenced and analysed. Results: In silico typing and transposon/plasmid assembly revealed that the sequenced isolates represented (in most cases) different hospital-adapted STs and were associated with a variety of different Tn1546 variants and plasmid backbone structures. Conclusions: The recent emergence of vanA VRE in Australia was polyclonal and not associatedwith the dissemination of a single 'dominant' ST or vanA-encoding plasmid. Interestingly, the factors contributing to this epidemiological change are not known and future studies may need to consider investigation of potential community sources. 2017 Journal Article http://hdl.handle.net/20.500.11937/67550 10.1093/jac/dkw539 Oxford University Press restricted |
| spellingShingle | van Hal, S. Espedido, B. Coombs, Geoffrey Howden, B. Korman, T. Nimmo, G. Gosbell, I. Jensen, S. Polyclonal emergence of vanA vancomycin-resistant Enterococcus faecium in Australia |
| title | Polyclonal emergence of vanA vancomycin-resistant Enterococcus faecium in Australia |
| title_full | Polyclonal emergence of vanA vancomycin-resistant Enterococcus faecium in Australia |
| title_fullStr | Polyclonal emergence of vanA vancomycin-resistant Enterococcus faecium in Australia |
| title_full_unstemmed | Polyclonal emergence of vanA vancomycin-resistant Enterococcus faecium in Australia |
| title_short | Polyclonal emergence of vanA vancomycin-resistant Enterococcus faecium in Australia |
| title_sort | polyclonal emergence of vana vancomycin-resistant enterococcus faecium in australia |
| url | http://hdl.handle.net/20.500.11937/67550 |