Conserved role of intragenic DNA methylation in regulating alternative promoters

Conserved role of intragenic DNA methylation in regulating alternative promoters

Although it is known that the methylation of DNA in 5' promoters suppresses gene expression, the role of DNA methylation in gene bodies is unclear. In mammals, tissue-and cell type-specific methylation is present in a small percentage of 5' CpG island (CGI) promoters, whereas a far greater...

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Bibliographic Details
Main Authors: Maunakea, A., Nagarajan, R., Bilenky, M., Ballinger, T., Dsouza, C., Fouse, S., Johnson, B., Hong, C., Nielsen, C., Zhao, Y., Turecki, G., Delaney, A., Varhol, Richard, Thiessen, N., Shchors, K., Heine, V., Rowitch, D., Xing, X., Fiore, C., Schillebeeckx, M., Jones, S., Haussler, D., Marra, M., Hirst, M., Wang, T., Costello, J.
Format: Journal Article
Published: Nature Publishing Group 2010
Online Access:http://hdl.handle.net/20.500.11937/6743

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