Activation of the NLRP3 inflammasome by islet amyloid polypeptide provides a mechanism for enhanced IL-1ß 2 in type 2 diabetes

Activation of the NLRP3 inflammasome by islet amyloid polypeptide provides a mechanism for enhanced IL-1ß 2 in type 2 diabetes

Interleukin 1ß 2 (IL-1ß 2) is an important inflammatory mediator of type 2 diabetes. Here we show that oligomers of islet amyloid polypeptide (IAPP), a protein that forms amyloid deposits in the pancreas during type 2 diabetes, triggered the NLRP3 inflammasome and generated mature IL-1ß 2. One thera...

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Bibliographic Details
Main Authors: Masters, S., Dunne, A., Subramanian, S., Hull, R., Tannahill, G., Sharp, F., Becker, C., Franchi, L., Yoshihara, E., Chen, Z., Mullooly, N., Mielke, L., Harris, J., Coll, R., Mills, K., Mok, K., Newsholme, Philip, Nuñez, G., Yodoi, J., Kahn, S., Lavelle, E., O'Neill, L.
Format: Journal Article
Published: Nature Publishing Group 2010
Online Access:http://hdl.handle.net/20.500.11937/6738

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