Multiplatform analysis of 12 cancer types reveals molecular classification within and across tissues of origin

Â© 2014 Elsevier Inc. Recent genomic analyses of pathologically defined tumor types identify 'within-a-tissue' disease subtypes. However, the extent to which genomic signatures are shared across tissues is still unclear. We performed an integrative analysis using five genome-wide platforms...

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Main Authors:	Hoadley, K., Yau, C., Wolf, D., Cherniack, A., Tamborero, D., Ng, S., Leiserson, M., Niu, B., McLellan, M., Uzunangelov, V., Zhang, J., Kandoth, C., Akbani, R., Shen, H., Omberg, L., Chu, A., Margolin, A., van't Veer, L., Lopez-Bigas, N., Laird, P., Raphael, B., Ding, L., Robertson, A., Byers, L., Mills, G., Weinstein, J., Van Waes, C., Chen, Z., Collisson, E., Benz, C., Perou, C., Stuart, J., Abbott, R., Abbott, S., Aksoy, B., Aldape, K., Ally, A., Amin, S., Anastassiou, D., Auman, J., Baggerly, K., Balasundaram, M., Balu, S., Baylin, S., Benz, S., Berman, B., Bernard, B., Bhatt, A., Birol, I., Black, A., Bodenheimer, T., Bootwalla, M., Bowen, J., Bressler, R., Bristow, C., Brooks, A., Broom, B., Buda, E., Burton, R., Butterfield, Y., Carlin, D., Carter, S., Casasent, T., Chang, K., Chanock, S., Chin, L., Cho, D., Cho, J., Chuah, E., Chun, H., Cibulskis, K., Ciriello, G., Cleland, J., Cline, M., Craft, B., Creighton, C., Danilova, L., Davidsen, T., Davis, C., Dees, N., Delehaunty, K., Demchok, J., Dhalla, N., DiCara, D., Dinh, H., Dobson, J., Dodda, D., Doddapaneni, H., Donehower, L., Dooling, D., Dresdner, G., Drummond, J., Eakin, A., Edgerton, M., Eldred, J., Eley, G., Ellrott, K., Fan, C., Fei, S., Felau, I., Frazer, S., Freeman, S., Frick, J., Fronick, C., Fulton, L., Fulton, R., Gabriel, S., Gao, J., Gastier-Foster, J., Gehlenborg, N., George, M., Getz, G., Gibbs, R., Goldman, M., Gonzalez-Perez, A., Gross, B., Guin, R., Gunaratne, P., Hadjipanayis, A., Hamilton, M., Hamilton, S., Han, L., Han, Y., Harper, H., Haseley, P., Haussler, D., Hayes, D., Heiman, D., Helman, E., Helsel, C., Herbrich, S., Herman, J., Hinoue, T., Hirst, C., Hirst, M., Holt, R., Hoyle, A., Iype, L., Jacobsen, A., Jeffreys, S., Jensen, M., Jones, C., Jones, S., Ju, Z., Jung, J., Kahles, A., Kahn, A., Kalicki-Veizer, J., Kalra, D., Kanchi, K., Kane, D., Kim, H., Kim, J., Knijnenburg, T., Koboldt, D., Kovar, C., Kramer, R., Kreisberg, R., Kucherlapati, R., Ladanyi, M., Lander, E., Larson, D., Lawrence, M., Lee, D., Lee, E., Lee, S., Lee, W., Lehmann, K., Leinonen, K., Leraas, K., Lerner, S., Levine, D., Lewis, L., Ley, T., Li, H., Li, J., Li, W., Liang, H., Lichtenberg, T., Lin, J., Lin, L., Lin, P., Liu, W., Liu, Y., Lorenzi, P., Lu, C., Lu, Y., Luquette, L., Ma, S., Magrini, V., Mahadeshwar, H., Mardis, E., Marra, M., Mayo, M., McAllister, C., McGuire, S., McMichael, J., Melott, J., Meng, S., Meyerson, M., Mieczkowski, P., Miller, C., Miller, M., Moore, R., Morgan, M., Morton, D., Mose, L., Mungall, A., Muzny, D., Nguyen, L., Noble, M., Noushmehr, H., O'Laughlin, M., Ojesina, A., Yang, T., Ozenberger, B., Pantazi, A., Parfenov, M., Park, P., Parker, J., Paull, E., Pedamallu, C., Pihl, T., Pohl, C., Pot, D., Protopopov, A., Przytycka, T., Radenbaugh, A., Ramirez, N., Ramirez, R., Ratsch, G., Reid, J., Ren, X., Reva, B., Reynolds, S., Rhie, S., Roach, J., Rovira, H., Ryan, M., Saksena, G., Salama, S., Sander, C., Santoso, N., Schein, J., Schmidt, H., Schultz, N., Schumacher, S., Seidman, J., Senbabaoglu, Y., Seth, S., Sharpe, S., Shen, R., Sheth, M., Shi, Y., Shmulevich, I., Silva, G., Simons, J., Sinha, R., Sipahimalani, P., Smith, S., Sofia, H., Sokolov, A., Soloway, M., Song, X., Sougnez, C., Spellman, P., Staudt, L., Stewart, C., Stojanov, P., Su, X., Sumer, S., Sun, Y., Swatloski, T., Tabak, B., Tam, A., Tan, D., Tang, J., Tarnuzzer, R., Taylor, B., Thiessen, N., Thorsson, V., Triche, T., Van Den Berg, D., Vandin, F., Varhol, Richard, Vaske, C., Veluvolu, U., Verhaak, R., Voet, D., Walker, J., Wallis, J., Waltman, P., Wan, Y., Wang, M., Wang, W., Wang, Z., Waring, S., Weinhold, N., Weisenberger, D., Wendl, M., Wheeler, D., Wilkerson, M., Wilson, R., Wise, L., Wong, A., Wu, C., Wu, H., Wu, J., Wylie, T., Xi, L., Xi, R., Xia, Z., Xu, A., Yang, D., Yang, L., Yang, Y., Yao, J., Yao, R., Ye, K., Yoshihara, K., Yuan, Y., Yung, A., Zack, T., Zeng, D., Zenklusen, J., Zhang, H., Zhang, N., Zhang, Q., Zhang, W., Zhao, W., Zheng, S., Zhu, J., Zmuda, E., Zou, L.
Format:	Journal Article
Published:	Cell Press 2014
Online Access:	http://hdl.handle.net/20.500.11937/66536

_version_	1848761345808269312
author	Hoadley, K. Yau, C. Wolf, D. Cherniack, A. Tamborero, D. Ng, S. Leiserson, M. Niu, B. McLellan, M. Uzunangelov, V. Zhang, J. Kandoth, C. Akbani, R. Shen, H. Omberg, L. Chu, A. Margolin, A. van't Veer, L. Lopez-Bigas, N. Laird, P. Raphael, B. Ding, L. Robertson, A. Byers, L. Mills, G. Weinstein, J. Van Waes, C. Chen, Z. Collisson, E. Benz, C. Perou, C. Stuart, J. Abbott, R. Abbott, S. Aksoy, B. Aldape, K. Ally, A. Amin, S. Anastassiou, D. Auman, J. Baggerly, K. Balasundaram, M. Balu, S. Baylin, S. Benz, S. Berman, B. Bernard, B. Bhatt, A. Birol, I. Black, A. Bodenheimer, T. Bootwalla, M. Bowen, J. Bressler, R. Bristow, C. Brooks, A. Broom, B. Buda, E. Burton, R. Butterfield, Y. Carlin, D. Carter, S. Casasent, T. Chang, K. Chanock, S. Chin, L. Cho, D. Cho, J. Chuah, E. Chun, H. Cibulskis, K. Ciriello, G. Cleland, J. Cline, M. Craft, B. Creighton, C. Danilova, L. Davidsen, T. Davis, C. Dees, N. Delehaunty, K. Demchok, J. Dhalla, N. DiCara, D. Dinh, H. Dobson, J. Dodda, D. Doddapaneni, H. Donehower, L. Dooling, D. Dresdner, G. Drummond, J. Eakin, A. Edgerton, M. Eldred, J. Eley, G. Ellrott, K. Fan, C. Fei, S. Felau, I. Frazer, S. Freeman, S. Frick, J. Fronick, C. Fulton, L. Fulton, R. Gabriel, S. Gao, J. Gastier-Foster, J. Gehlenborg, N. George, M. Getz, G. Gibbs, R. Goldman, M. Gonzalez-Perez, A. Gross, B. Guin, R. Gunaratne, P. Hadjipanayis, A. Hamilton, M. Hamilton, S. Han, L. Han, Y. Harper, H. Haseley, P. Haussler, D. Hayes, D. Heiman, D. Helman, E. Helsel, C. Herbrich, S. Herman, J. Hinoue, T. Hirst, C. Hirst, M. Holt, R. Hoyle, A. Iype, L. Jacobsen, A. Jeffreys, S. Jensen, M. Jones, C. Jones, S. Ju, Z. Jung, J. Kahles, A. Kahn, A. Kalicki-Veizer, J. Kalra, D. Kanchi, K. Kane, D. Kim, H. Kim, J. Knijnenburg, T. Koboldt, D. Kovar, C. Kramer, R. Kreisberg, R. Kucherlapati, R. Ladanyi, M. Lander, E. Larson, D. Lawrence, M. Lee, D. Lee, E. Lee, S. Lee, W. Lehmann, K. Leinonen, K. Leraas, K. Lerner, S. Levine, D. Lewis, L. Ley, T. Li, H. Li, J. Li, W. Liang, H. Lichtenberg, T. Lin, J. Lin, L. Lin, P. Liu, W. Liu, Y. Liu, Y. Lorenzi, P. Lu, C. Lu, Y. Luquette, L. Ma, S. Magrini, V. Mahadeshwar, H. Mardis, E. Margolin, A. Marra, M. Mayo, M. McAllister, C. McGuire, S. McMichael, J. Melott, J. Meng, S. Meyerson, M. Mieczkowski, P. Miller, C. Miller, M. Miller, M. Moore, R. Morgan, M. Morton, D. Mose, L. Mungall, A. Muzny, D. Nguyen, L. Noble, M. Noushmehr, H. O'Laughlin, M. Ojesina, A. Yang, T. Ozenberger, B. Pantazi, A. Parfenov, M. Park, P. Parker, J. Paull, E. Pedamallu, C. Pihl, T. Pohl, C. Pot, D. Protopopov, A. Przytycka, T. Radenbaugh, A. Ramirez, N. Ramirez, R. Ratsch, G. Reid, J. Ren, X. Reva, B. Reynolds, S. Rhie, S. Roach, J. Rovira, H. Ryan, M. Saksena, G. Salama, S. Sander, C. Santoso, N. Schein, J. Schmidt, H. Schultz, N. Schumacher, S. Seidman, J. Senbabaoglu, Y. Seth, S. Sharpe, S. Shen, R. Sheth, M. Shi, Y. Shmulevich, I. Silva, G. Simons, J. Sinha, R. Sipahimalani, P. Smith, S. Sofia, H. Sokolov, A. Soloway, M. Song, X. Sougnez, C. Spellman, P. Staudt, L. Stewart, C. Stojanov, P. Su, X. Sumer, S. Sun, Y. Swatloski, T. Tabak, B. Tam, A. Tan, D. Tang, J. Tarnuzzer, R. Taylor, B. Thiessen, N. Thorsson, V. Triche, T. Van Den Berg, D. Vandin, F. Varhol, Richard Vaske, C. Veluvolu, U. Verhaak, R. Voet, D. Walker, J. Wallis, J. Waltman, P. Wan, Y. Wang, M. Wang, W. Wang, Z. Waring, S. Weinhold, N. Weisenberger, D. Wendl, M. Wheeler, D. Wilkerson, M. Wilson, R. Wise, L. Wong, A. Wu, C. Wu, C. Wu, H. Wu, J. Wylie, T. Xi, L. Xi, R. Xia, Z. Xu, A. Yang, D. Yang, L. Yang, L. Yang, Y. Yao, J. Yao, R. Ye, K. Yoshihara, K. Yuan, Y. Yung, A. Zack, T. Zeng, D. Zenklusen, J. Zhang, H. Zhang, J. Zhang, N. Zhang, Q. Zhang, W. Zhao, W. Zheng, S. Zhu, J. Zmuda, E. Zou, L.
author_facet	Hoadley, K. Yau, C. Wolf, D. Cherniack, A. Tamborero, D. Ng, S. Leiserson, M. Niu, B. McLellan, M. Uzunangelov, V. Zhang, J. Kandoth, C. Akbani, R. Shen, H. Omberg, L. Chu, A. Margolin, A. van't Veer, L. Lopez-Bigas, N. Laird, P. Raphael, B. Ding, L. Robertson, A. Byers, L. Mills, G. Weinstein, J. Van Waes, C. Chen, Z. Collisson, E. Benz, C. Perou, C. Stuart, J. Abbott, R. Abbott, S. Aksoy, B. Aldape, K. Ally, A. Amin, S. Anastassiou, D. Auman, J. Baggerly, K. Balasundaram, M. Balu, S. Baylin, S. Benz, S. Berman, B. Bernard, B. Bhatt, A. Birol, I. Black, A. Bodenheimer, T. Bootwalla, M. Bowen, J. Bressler, R. Bristow, C. Brooks, A. Broom, B. Buda, E. Burton, R. Butterfield, Y. Carlin, D. Carter, S. Casasent, T. Chang, K. Chanock, S. Chin, L. Cho, D. Cho, J. Chuah, E. Chun, H. Cibulskis, K. Ciriello, G. Cleland, J. Cline, M. Craft, B. Creighton, C. Danilova, L. Davidsen, T. Davis, C. Dees, N. Delehaunty, K. Demchok, J. Dhalla, N. DiCara, D. Dinh, H. Dobson, J. Dodda, D. Doddapaneni, H. Donehower, L. Dooling, D. Dresdner, G. Drummond, J. Eakin, A. Edgerton, M. Eldred, J. Eley, G. Ellrott, K. Fan, C. Fei, S. Felau, I. Frazer, S. Freeman, S. Frick, J. Fronick, C. Fulton, L. Fulton, R. Gabriel, S. Gao, J. Gastier-Foster, J. Gehlenborg, N. George, M. Getz, G. Gibbs, R. Goldman, M. Gonzalez-Perez, A. Gross, B. Guin, R. Gunaratne, P. Hadjipanayis, A. Hamilton, M. Hamilton, S. Han, L. Han, Y. Harper, H. Haseley, P. Haussler, D. Hayes, D. Heiman, D. Helman, E. Helsel, C. Herbrich, S. Herman, J. Hinoue, T. Hirst, C. Hirst, M. Holt, R. Hoyle, A. Iype, L. Jacobsen, A. Jeffreys, S. Jensen, M. Jones, C. Jones, S. Ju, Z. Jung, J. Kahles, A. Kahn, A. Kalicki-Veizer, J. Kalra, D. Kanchi, K. Kane, D. Kim, H. Kim, J. Knijnenburg, T. Koboldt, D. Kovar, C. Kramer, R. Kreisberg, R. Kucherlapati, R. Ladanyi, M. Lander, E. Larson, D. Lawrence, M. Lee, D. Lee, E. Lee, S. Lee, W. Lehmann, K. Leinonen, K. Leraas, K. Lerner, S. Levine, D. Lewis, L. Ley, T. Li, H. Li, J. Li, W. Liang, H. Lichtenberg, T. Lin, J. Lin, L. Lin, P. Liu, W. Liu, Y. Liu, Y. Lorenzi, P. Lu, C. Lu, Y. Luquette, L. Ma, S. Magrini, V. Mahadeshwar, H. Mardis, E. Margolin, A. Marra, M. Mayo, M. McAllister, C. McGuire, S. McMichael, J. Melott, J. Meng, S. Meyerson, M. Mieczkowski, P. Miller, C. Miller, M. Miller, M. Moore, R. Morgan, M. Morton, D. Mose, L. Mungall, A. Muzny, D. Nguyen, L. Noble, M. Noushmehr, H. O'Laughlin, M. Ojesina, A. Yang, T. Ozenberger, B. Pantazi, A. Parfenov, M. Park, P. Parker, J. Paull, E. Pedamallu, C. Pihl, T. Pohl, C. Pot, D. Protopopov, A. Przytycka, T. Radenbaugh, A. Ramirez, N. Ramirez, R. Ratsch, G. Reid, J. Ren, X. Reva, B. Reynolds, S. Rhie, S. Roach, J. Rovira, H. Ryan, M. Saksena, G. Salama, S. Sander, C. Santoso, N. Schein, J. Schmidt, H. Schultz, N. Schumacher, S. Seidman, J. Senbabaoglu, Y. Seth, S. Sharpe, S. Shen, R. Sheth, M. Shi, Y. Shmulevich, I. Silva, G. Simons, J. Sinha, R. Sipahimalani, P. Smith, S. Sofia, H. Sokolov, A. Soloway, M. Song, X. Sougnez, C. Spellman, P. Staudt, L. Stewart, C. Stojanov, P. Su, X. Sumer, S. Sun, Y. Swatloski, T. Tabak, B. Tam, A. Tan, D. Tang, J. Tarnuzzer, R. Taylor, B. Thiessen, N. Thorsson, V. Triche, T. Van Den Berg, D. Vandin, F. Varhol, Richard Vaske, C. Veluvolu, U. Verhaak, R. Voet, D. Walker, J. Wallis, J. Waltman, P. Wan, Y. Wang, M. Wang, W. Wang, Z. Waring, S. Weinhold, N. Weisenberger, D. Wendl, M. Wheeler, D. Wilkerson, M. Wilson, R. Wise, L. Wong, A. Wu, C. Wu, C. Wu, H. Wu, J. Wylie, T. Xi, L. Xi, R. Xia, Z. Xu, A. Yang, D. Yang, L. Yang, L. Yang, Y. Yao, J. Yao, R. Ye, K. Yoshihara, K. Yuan, Y. Yung, A. Zack, T. Zeng, D. Zenklusen, J. Zhang, H. Zhang, J. Zhang, N. Zhang, Q. Zhang, W. Zhao, W. Zheng, S. Zhu, J. Zmuda, E. Zou, L.
author_sort	Hoadley, K.
building	Curtin Institutional Repository
collection	Online Access
description	Â© 2014 Elsevier Inc. Recent genomic analyses of pathologically defined tumor types identify 'within-a-tissue' disease subtypes. However, the extent to which genomic signatures are shared across tissues is still unclear. We performed an integrative analysis using five genome-wide platforms and one proteomic platform on 3,527 specimens from 12 cancer types, revealing a unified classification into 11 major subtypes. Five subtypes were nearly identical to their tissue-oforigin counterparts, but several distinct cancer types were found to converge into common subtypes. Lung squamous, head and neck, and a subset of bladder cancers coalesced into one subtype typified by TP53 alterations, TP63 amplifications, and high expression of immune and proliferation pathway genes. Of note, bladder cancers split into three pancancer subtypes. The multiplatform classification, while correlated with tissue-of-origin, provides independent information for predicting clinical outcomes. All data sets are available for data-mining from a unified resource to support further biological discoveries and insights into novel therapeutic strategies.
first_indexed	2025-11-14T10:30:12Z
format	Journal Article
id	curtin-20.500.11937-66536
institution	Curtin University Malaysia
institution_category	Local University
last_indexed	2025-11-14T10:30:12Z
publishDate	2014
publisher	Cell Press
recordtype	eprints
repository_type	Digital Repository
spelling	curtin-20.500.11937-665362018-04-30T02:49:04Z Multiplatform analysis of 12 cancer types reveals molecular classification within and across tissues of origin Hoadley, K. Yau, C. Wolf, D. Cherniack, A. Tamborero, D. Ng, S. Leiserson, M. Niu, B. McLellan, M. Uzunangelov, V. Zhang, J. Kandoth, C. Akbani, R. Shen, H. Omberg, L. Chu, A. Margolin, A. van't Veer, L. Lopez-Bigas, N. Laird, P. Raphael, B. Ding, L. Robertson, A. Byers, L. Mills, G. Weinstein, J. Van Waes, C. Chen, Z. Collisson, E. Benz, C. Perou, C. Stuart, J. Abbott, R. Abbott, S. Aksoy, B. Aldape, K. Ally, A. Amin, S. Anastassiou, D. Auman, J. Baggerly, K. Balasundaram, M. Balu, S. Baylin, S. Benz, S. Berman, B. Bernard, B. Bhatt, A. Birol, I. Black, A. Bodenheimer, T. Bootwalla, M. Bowen, J. Bressler, R. Bristow, C. Brooks, A. Broom, B. Buda, E. Burton, R. Butterfield, Y. Carlin, D. Carter, S. Casasent, T. Chang, K. Chanock, S. Chin, L. Cho, D. Cho, J. Chuah, E. Chun, H. Cibulskis, K. Ciriello, G. Cleland, J. Cline, M. Craft, B. Creighton, C. Danilova, L. Davidsen, T. Davis, C. Dees, N. Delehaunty, K. Demchok, J. Dhalla, N. DiCara, D. Dinh, H. Dobson, J. Dodda, D. Doddapaneni, H. Donehower, L. Dooling, D. Dresdner, G. Drummond, J. Eakin, A. Edgerton, M. Eldred, J. Eley, G. Ellrott, K. Fan, C. Fei, S. Felau, I. Frazer, S. Freeman, S. Frick, J. Fronick, C. Fulton, L. Fulton, R. Gabriel, S. Gao, J. Gastier-Foster, J. Gehlenborg, N. George, M. Getz, G. Gibbs, R. Goldman, M. Gonzalez-Perez, A. Gross, B. Guin, R. Gunaratne, P. Hadjipanayis, A. Hamilton, M. Hamilton, S. Han, L. Han, Y. Harper, H. Haseley, P. Haussler, D. Hayes, D. Heiman, D. Helman, E. Helsel, C. Herbrich, S. Herman, J. Hinoue, T. Hirst, C. Hirst, M. Holt, R. Hoyle, A. Iype, L. Jacobsen, A. Jeffreys, S. Jensen, M. Jones, C. Jones, S. Ju, Z. Jung, J. Kahles, A. Kahn, A. Kalicki-Veizer, J. Kalra, D. Kanchi, K. Kane, D. Kim, H. Kim, J. Knijnenburg, T. Koboldt, D. Kovar, C. Kramer, R. Kreisberg, R. Kucherlapati, R. Ladanyi, M. Lander, E. Larson, D. Lawrence, M. Lee, D. Lee, E. Lee, S. Lee, W. Lehmann, K. Leinonen, K. Leraas, K. Lerner, S. Levine, D. Lewis, L. Ley, T. Li, H. Li, J. Li, W. Liang, H. Lichtenberg, T. Lin, J. Lin, L. Lin, P. Liu, W. Liu, Y. Liu, Y. Lorenzi, P. Lu, C. Lu, Y. Luquette, L. Ma, S. Magrini, V. Mahadeshwar, H. Mardis, E. Margolin, A. Marra, M. Mayo, M. McAllister, C. McGuire, S. McMichael, J. Melott, J. Meng, S. Meyerson, M. Mieczkowski, P. Miller, C. Miller, M. Miller, M. Moore, R. Morgan, M. Morton, D. Mose, L. Mungall, A. Muzny, D. Nguyen, L. Noble, M. Noushmehr, H. O'Laughlin, M. Ojesina, A. Yang, T. Ozenberger, B. Pantazi, A. Parfenov, M. Park, P. Parker, J. Paull, E. Pedamallu, C. Pihl, T. Pohl, C. Pot, D. Protopopov, A. Przytycka, T. Radenbaugh, A. Ramirez, N. Ramirez, R. Ratsch, G. Reid, J. Ren, X. Reva, B. Reynolds, S. Rhie, S. Roach, J. Rovira, H. Ryan, M. Saksena, G. Salama, S. Sander, C. Santoso, N. Schein, J. Schmidt, H. Schultz, N. Schumacher, S. Seidman, J. Senbabaoglu, Y. Seth, S. Sharpe, S. Shen, R. Sheth, M. Shi, Y. Shmulevich, I. Silva, G. Simons, J. Sinha, R. Sipahimalani, P. Smith, S. Sofia, H. Sokolov, A. Soloway, M. Song, X. Sougnez, C. Spellman, P. Staudt, L. Stewart, C. Stojanov, P. Su, X. Sumer, S. Sun, Y. Swatloski, T. Tabak, B. Tam, A. Tan, D. Tang, J. Tarnuzzer, R. Taylor, B. Thiessen, N. Thorsson, V. Triche, T. Van Den Berg, D. Vandin, F. Varhol, Richard Vaske, C. Veluvolu, U. Verhaak, R. Voet, D. Walker, J. Wallis, J. Waltman, P. Wan, Y. Wang, M. Wang, W. Wang, Z. Waring, S. Weinhold, N. Weisenberger, D. Wendl, M. Wheeler, D. Wilkerson, M. Wilson, R. Wise, L. Wong, A. Wu, C. Wu, C. Wu, H. Wu, J. Wylie, T. Xi, L. Xi, R. Xia, Z. Xu, A. Yang, D. Yang, L. Yang, L. Yang, Y. Yao, J. Yao, R. Ye, K. Yoshihara, K. Yuan, Y. Yung, A. Zack, T. Zeng, D. Zenklusen, J. Zhang, H. Zhang, J. Zhang, N. Zhang, Q. Zhang, W. Zhao, W. Zheng, S. Zhu, J. Zmuda, E. Zou, L. Â© 2014 Elsevier Inc. Recent genomic analyses of pathologically defined tumor types identify 'within-a-tissue' disease subtypes. However, the extent to which genomic signatures are shared across tissues is still unclear. We performed an integrative analysis using five genome-wide platforms and one proteomic platform on 3,527 specimens from 12 cancer types, revealing a unified classification into 11 major subtypes. Five subtypes were nearly identical to their tissue-oforigin counterparts, but several distinct cancer types were found to converge into common subtypes. Lung squamous, head and neck, and a subset of bladder cancers coalesced into one subtype typified by TP53 alterations, TP63 amplifications, and high expression of immune and proliferation pathway genes. Of note, bladder cancers split into three pancancer subtypes. The multiplatform classification, while correlated with tissue-of-origin, provides independent information for predicting clinical outcomes. All data sets are available for data-mining from a unified resource to support further biological discoveries and insights into novel therapeutic strategies. 2014 Journal Article http://hdl.handle.net/20.500.11937/66536 10.1016/j.cell.2014.06.049 Cell Press restricted
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title	Multiplatform analysis of 12 cancer types reveals molecular classification within and across tissues of origin
title_full	Multiplatform analysis of 12 cancer types reveals molecular classification within and across tissues of origin
title_fullStr	Multiplatform analysis of 12 cancer types reveals molecular classification within and across tissues of origin
title_full_unstemmed	Multiplatform analysis of 12 cancer types reveals molecular classification within and across tissues of origin
title_short	Multiplatform analysis of 12 cancer types reveals molecular classification within and across tissues of origin
title_sort	multiplatform analysis of 12 cancer types reveals molecular classification within and across tissues of origin
url	http://hdl.handle.net/20.500.11937/66536

Multiplatform analysis of 12 cancer types reveals molecular classification within and across tissues of origin

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