Three-dimensional printing of shape memory hydrogels with internal structure for drug delivery
© 2017 Elsevier B.V. Hydrogels with shape memory behavior and internal structure have wide applications in fields ranging from tissue engineering and medical instruments to drug delivery; however, creating the hydrogels has proven to be extremely challenging. This study presents a three-dimensional...
| Main Authors: | , , , , , , , |
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| Format: | Journal Article |
| Published: |
Elsevier
2017
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| Online Access: | http://hdl.handle.net/20.500.11937/66437 |
| _version_ | 1848761321871376384 |
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| author | Wang, Y. Miao, Y. Zhang, J. Wu, J. Kirk, Brett Xu, J. Ma, D. Xue, W. |
| author_facet | Wang, Y. Miao, Y. Zhang, J. Wu, J. Kirk, Brett Xu, J. Ma, D. Xue, W. |
| author_sort | Wang, Y. |
| building | Curtin Institutional Repository |
| collection | Online Access |
| description | © 2017 Elsevier B.V. Hydrogels with shape memory behavior and internal structure have wide applications in fields ranging from tissue engineering and medical instruments to drug delivery; however, creating the hydrogels has proven to be extremely challenging. This study presents a three-dimensional (3D) printing technology to fabricate the shape memory hydrogels with internal structure (SMHs) by combining sodium alginate (alginate) and pluronic F127 diacrylate macromer (F127DA). SMHs were constituted by a dual network structure. One is a stable network which is formed by F127DA photo-crosslinking; the other one is a reversible network which is formed by Ca 2 + cross-linked alginate. SMHs recovery ratio was 98.15% in 10 min after Ca 2 + was removed in the Na 2 CO 3 solution, and the elastic modulus remains essentially stable after the shape memory cycle. It showed that the drug releasing rate is more rapid compared with traditional drug-loaded hydrogels in in vitro experiments. The viability of 3T3 fibroblasts remained intact which revealed its excellent biocompatibility. Therefore, SMHs have a huge prospect for application in drug carriers and tissue engineering scaffold. |
| first_indexed | 2025-11-14T10:29:49Z |
| format | Journal Article |
| id | curtin-20.500.11937-66437 |
| institution | Curtin University Malaysia |
| institution_category | Local University |
| last_indexed | 2025-11-14T10:29:49Z |
| publishDate | 2017 |
| publisher | Elsevier |
| recordtype | eprints |
| repository_type | Digital Repository |
| spelling | curtin-20.500.11937-664372018-04-30T02:48:32Z Three-dimensional printing of shape memory hydrogels with internal structure for drug delivery Wang, Y. Miao, Y. Zhang, J. Wu, J. Kirk, Brett Xu, J. Ma, D. Xue, W. © 2017 Elsevier B.V. Hydrogels with shape memory behavior and internal structure have wide applications in fields ranging from tissue engineering and medical instruments to drug delivery; however, creating the hydrogels has proven to be extremely challenging. This study presents a three-dimensional (3D) printing technology to fabricate the shape memory hydrogels with internal structure (SMHs) by combining sodium alginate (alginate) and pluronic F127 diacrylate macromer (F127DA). SMHs were constituted by a dual network structure. One is a stable network which is formed by F127DA photo-crosslinking; the other one is a reversible network which is formed by Ca 2 + cross-linked alginate. SMHs recovery ratio was 98.15% in 10 min after Ca 2 + was removed in the Na 2 CO 3 solution, and the elastic modulus remains essentially stable after the shape memory cycle. It showed that the drug releasing rate is more rapid compared with traditional drug-loaded hydrogels in in vitro experiments. The viability of 3T3 fibroblasts remained intact which revealed its excellent biocompatibility. Therefore, SMHs have a huge prospect for application in drug carriers and tissue engineering scaffold. 2017 Journal Article http://hdl.handle.net/20.500.11937/66437 10.1016/j.msec.2017.11.025 Elsevier restricted |
| spellingShingle | Wang, Y. Miao, Y. Zhang, J. Wu, J. Kirk, Brett Xu, J. Ma, D. Xue, W. Three-dimensional printing of shape memory hydrogels with internal structure for drug delivery |
| title | Three-dimensional printing of shape memory hydrogels with internal structure for drug delivery |
| title_full | Three-dimensional printing of shape memory hydrogels with internal structure for drug delivery |
| title_fullStr | Three-dimensional printing of shape memory hydrogels with internal structure for drug delivery |
| title_full_unstemmed | Three-dimensional printing of shape memory hydrogels with internal structure for drug delivery |
| title_short | Three-dimensional printing of shape memory hydrogels with internal structure for drug delivery |
| title_sort | three-dimensional printing of shape memory hydrogels with internal structure for drug delivery |
| url | http://hdl.handle.net/20.500.11937/66437 |