Development of fungal sterol biosynthesis inhibitors as new drug leads for the treatment of Chagas disease

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Development of fungal sterol biosynthesis inhibitors as new drug leads for the treatment of Chagas disease

Pyrifenox is a potential drug candidate for the treatment of Chagas disease. A new modular synthesis was established to make pyrifenox and its analogues. These analogues lead to the discovery of compounds that inhibited the causative parasite, Trypanosoma cruzi, at the nanomolar range and the discov...

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Bibliographic Details
Main Author:	Smith, Erin Nicole
Format:	Thesis
Language:	English
Published:	Curtin University 2014
Online Access:	http://hdl.handle.net/20.500.11937/662

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