Development of fungal sterol biosynthesis inhibitors as new drug leads for the treatment of Chagas disease
Pyrifenox is a potential drug candidate for the treatment of Chagas disease. A new modular synthesis was established to make pyrifenox and its analogues. These analogues lead to the discovery of compounds that inhibited the causative parasite, Trypanosoma cruzi, at the nanomolar range and the discov...
| Main Author: | |
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| Format: | Thesis |
| Language: | English |
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Curtin University
2014
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| Online Access: | http://hdl.handle.net/20.500.11937/662 |
| _version_ | 1848743443452395520 |
|---|---|
| author | Smith, Erin Nicole |
| author_facet | Smith, Erin Nicole |
| author_sort | Smith, Erin Nicole |
| building | Curtin Institutional Repository |
| collection | Online Access |
| description | Pyrifenox is a potential drug candidate for the treatment of Chagas disease. A new modular synthesis was established to make pyrifenox and its analogues. These analogues lead to the discovery of compounds that inhibited the causative parasite, Trypanosoma cruzi, at the nanomolar range and the discovery of a new class of compound for the potential treatment of Chagas disease |
| first_indexed | 2025-11-14T05:45:39Z |
| format | Thesis |
| id | curtin-20.500.11937-662 |
| institution | Curtin University Malaysia |
| institution_category | Local University |
| language | English |
| last_indexed | 2025-11-14T05:45:39Z |
| publishDate | 2014 |
| publisher | Curtin University |
| recordtype | eprints |
| repository_type | Digital Repository |
| spelling | curtin-20.500.11937-6622017-02-20T06:40:30Z Development of fungal sterol biosynthesis inhibitors as new drug leads for the treatment of Chagas disease Smith, Erin Nicole Pyrifenox is a potential drug candidate for the treatment of Chagas disease. A new modular synthesis was established to make pyrifenox and its analogues. These analogues lead to the discovery of compounds that inhibited the causative parasite, Trypanosoma cruzi, at the nanomolar range and the discovery of a new class of compound for the potential treatment of Chagas disease 2014 Thesis http://hdl.handle.net/20.500.11937/662 en Curtin University fulltext |
| spellingShingle | Smith, Erin Nicole Development of fungal sterol biosynthesis inhibitors as new drug leads for the treatment of Chagas disease |
| title | Development of fungal sterol biosynthesis inhibitors as new drug leads for the treatment of Chagas disease |
| title_full | Development of fungal sterol biosynthesis inhibitors as new drug leads for the treatment of Chagas disease |
| title_fullStr | Development of fungal sterol biosynthesis inhibitors as new drug leads for the treatment of Chagas disease |
| title_full_unstemmed | Development of fungal sterol biosynthesis inhibitors as new drug leads for the treatment of Chagas disease |
| title_short | Development of fungal sterol biosynthesis inhibitors as new drug leads for the treatment of Chagas disease |
| title_sort | development of fungal sterol biosynthesis inhibitors as new drug leads for the treatment of chagas disease |
| url | http://hdl.handle.net/20.500.11937/662 |