The effects of alcohol on ambulatory blood pressure and other cardiovascular risk factors in type 2 diabetes: A randomized intervention
Objective: Although prospective studies suggest light-to-moderate chronic alcohol intake protects against coronary artery disease in type 2 diabetic patients, the balance of effects on individual cardiovascular risk factors needs further assessment. We examined the effects of alcohol consumption on...
| Main Authors: | , , , , , |
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| Format: | Journal Article |
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Lippincott Williams & Wilkins
2016
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| Online Access: | http://hdl.handle.net/20.500.11937/6603 |
| _version_ | 1848745124311334912 |
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| author | Mori, T. Burke, V. Zilkens, Renate Hodgson, J. Beilin, L. Puddey, I. |
| author_facet | Mori, T. Burke, V. Zilkens, Renate Hodgson, J. Beilin, L. Puddey, I. |
| author_sort | Mori, T. |
| building | Curtin Institutional Repository |
| collection | Online Access |
| description | Objective: Although prospective studies suggest light-to-moderate chronic alcohol intake protects against coronary artery disease in type 2 diabetic patients, the balance of effects on individual cardiovascular risk factors needs further assessment. We examined the effects of alcohol consumption on 24-h ambulatory blood pressure (BP) and heart rate (HR), high-density lipoprotein cholesterol, fibrinogen, C-reactive protein, homocysteine, and glycaemic control in well controlled type 2 diabetes. Methods: Twenty-four participants aged 49-66 year were randomized to a three-period crossover study with women drinking red wine 230ml/day (~24g alcohol/day) and men drinking red wine 300ml/day (~31g alcohol/day), or equivalent volumes of dealcoholized red wine (DRW) or water, each for 4 weeks. Ambulatory BP and HR were monitored every 30min for 24h at the end of each period. Home blood glucose monitoring was carried out twice weekly throughout. Results: Red wine increased awake SBP and DBP relative to water by 2.5±1.2/1.9±0.7mmHg (P=0.033, P=0.008, respectively), with a similar nonsignificant trend relative to DRW. Asleep DBP fell with red wine relative to DRW (2.0±0.8mmHg, P=0.016) with a similar nonsignificant trend relative to water. Red wine increased 24-h, awake and asleep HR relative to water and DRW. Relative to DRW, red wine did not affect glycaemic control or any other cardiovascular risk factor.Conclusion: In well controlled type 2 diabetic individuals 24–31 g alcohol/day (∼2–3 standard drinks) raises awake BP and 24-h HR and lowers asleep BP but does not otherwise favourably or adversely modify cardiovascular risk factors. |
| first_indexed | 2025-11-14T06:12:22Z |
| format | Journal Article |
| id | curtin-20.500.11937-6603 |
| institution | Curtin University Malaysia |
| institution_category | Local University |
| last_indexed | 2025-11-14T06:12:22Z |
| publishDate | 2016 |
| publisher | Lippincott Williams & Wilkins |
| recordtype | eprints |
| repository_type | Digital Repository |
| spelling | curtin-20.500.11937-66032017-09-13T14:42:16Z The effects of alcohol on ambulatory blood pressure and other cardiovascular risk factors in type 2 diabetes: A randomized intervention Mori, T. Burke, V. Zilkens, Renate Hodgson, J. Beilin, L. Puddey, I. Objective: Although prospective studies suggest light-to-moderate chronic alcohol intake protects against coronary artery disease in type 2 diabetic patients, the balance of effects on individual cardiovascular risk factors needs further assessment. We examined the effects of alcohol consumption on 24-h ambulatory blood pressure (BP) and heart rate (HR), high-density lipoprotein cholesterol, fibrinogen, C-reactive protein, homocysteine, and glycaemic control in well controlled type 2 diabetes. Methods: Twenty-four participants aged 49-66 year were randomized to a three-period crossover study with women drinking red wine 230ml/day (~24g alcohol/day) and men drinking red wine 300ml/day (~31g alcohol/day), or equivalent volumes of dealcoholized red wine (DRW) or water, each for 4 weeks. Ambulatory BP and HR were monitored every 30min for 24h at the end of each period. Home blood glucose monitoring was carried out twice weekly throughout. Results: Red wine increased awake SBP and DBP relative to water by 2.5±1.2/1.9±0.7mmHg (P=0.033, P=0.008, respectively), with a similar nonsignificant trend relative to DRW. Asleep DBP fell with red wine relative to DRW (2.0±0.8mmHg, P=0.016) with a similar nonsignificant trend relative to water. Red wine increased 24-h, awake and asleep HR relative to water and DRW. Relative to DRW, red wine did not affect glycaemic control or any other cardiovascular risk factor.Conclusion: In well controlled type 2 diabetic individuals 24–31 g alcohol/day (∼2–3 standard drinks) raises awake BP and 24-h HR and lowers asleep BP but does not otherwise favourably or adversely modify cardiovascular risk factors. 2016 Journal Article http://hdl.handle.net/20.500.11937/6603 10.1097/HJH.0000000000000816 Lippincott Williams & Wilkins restricted |
| spellingShingle | Mori, T. Burke, V. Zilkens, Renate Hodgson, J. Beilin, L. Puddey, I. The effects of alcohol on ambulatory blood pressure and other cardiovascular risk factors in type 2 diabetes: A randomized intervention |
| title | The effects of alcohol on ambulatory blood pressure and other cardiovascular risk factors in type 2 diabetes: A randomized intervention |
| title_full | The effects of alcohol on ambulatory blood pressure and other cardiovascular risk factors in type 2 diabetes: A randomized intervention |
| title_fullStr | The effects of alcohol on ambulatory blood pressure and other cardiovascular risk factors in type 2 diabetes: A randomized intervention |
| title_full_unstemmed | The effects of alcohol on ambulatory blood pressure and other cardiovascular risk factors in type 2 diabetes: A randomized intervention |
| title_short | The effects of alcohol on ambulatory blood pressure and other cardiovascular risk factors in type 2 diabetes: A randomized intervention |
| title_sort | effects of alcohol on ambulatory blood pressure and other cardiovascular risk factors in type 2 diabetes: a randomized intervention |
| url | http://hdl.handle.net/20.500.11937/6603 |