A Lipid Transfer Protein Signaling Axis Exerts Dual Control of Cell-Cycle and Membrane Trafficking Systems

© 2017 Elsevier Inc. Kes1/Osh4 is a member of the conserved, but functionally enigmatic, oxysterol binding protein-related protein (ORP) superfamily that inhibits phosphatidylinositol transfer protein (Sec14)-dependent membrane trafficking through the trans-Golgi (TGN)/endosomal network. We now repo...

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Main Authors: Huang, J., Mousley, Carl, Dacquay, L., Maitra, N., Drin, G., He, C., Ridgway, N., Tripathi, A., Kennedy, M., Kennedy, B., Liu, W., Baetz, K., Polymenis, M., Bankaitis, V.
Format: Journal Article
Published: Cell Press 2018
Online Access:http://hdl.handle.net/20.500.11937/65893
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author Huang, J.
Mousley, Carl
Dacquay, L.
Maitra, N.
Drin, G.
He, C.
Ridgway, N.
Tripathi, A.
Kennedy, M.
Kennedy, B.
Liu, W.
Baetz, K.
Polymenis, M.
Bankaitis, V.
author_facet Huang, J.
Mousley, Carl
Dacquay, L.
Maitra, N.
Drin, G.
He, C.
Ridgway, N.
Tripathi, A.
Kennedy, M.
Kennedy, B.
Liu, W.
Baetz, K.
Polymenis, M.
Bankaitis, V.
author_sort Huang, J.
building Curtin Institutional Repository
collection Online Access
description © 2017 Elsevier Inc. Kes1/Osh4 is a member of the conserved, but functionally enigmatic, oxysterol binding protein-related protein (ORP) superfamily that inhibits phosphatidylinositol transfer protein (Sec14)-dependent membrane trafficking through the trans-Golgi (TGN)/endosomal network. We now report that Kes1, and select other ORPs, execute cell-cycle control activities as functionally non-redundant inhibitors of the G 1 /S transition when cells confront nutrient-poor environments and promote replicative aging. Kes1-dependent cell-cycle regulation requires the Greatwall/MASTL kinase ortholog Rim15, and is opposed by Sec14 activity in a mechanism independent of Kes1/Sec14 bulk membrane-trafficking functions. Moreover, the data identify Kes1 as a non-histone target for NuA4 through which this lysine acetyltransferase co-modulates membrane-trafficking and cell-cycle activities. We propose the Sec14/Kes1 lipid-exchange protein pair constitutes part of the mechanism for integrating TGN/endosomal lipid signaling with cell-cycle progression and hypothesize that ORPs define a family of stage-specific cell-cycle control factors that execute tumor-suppressor-like functions. Huang et al. demonstrate the yeast oxysterol-binding protein (ORP) homolog Kes1, and other ORPs, are inhibitors of the G 1 /S transition. They show that Kes1 is a non-histone target for the NuA4 lysine acetyltransferase and participates in a phosphatidylinositol-4-phopshate-dependent mechanism for integrating TGN/endosomal lipid signaling with cell-cycle progression.
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institution Curtin University Malaysia
institution_category Local University
last_indexed 2025-11-14T10:28:19Z
publishDate 2018
publisher Cell Press
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spelling curtin-20.500.11937-658932018-02-19T08:06:06Z A Lipid Transfer Protein Signaling Axis Exerts Dual Control of Cell-Cycle and Membrane Trafficking Systems Huang, J. Mousley, Carl Dacquay, L. Maitra, N. Drin, G. He, C. Ridgway, N. Tripathi, A. Kennedy, M. Kennedy, B. Liu, W. Baetz, K. Polymenis, M. Bankaitis, V. © 2017 Elsevier Inc. Kes1/Osh4 is a member of the conserved, but functionally enigmatic, oxysterol binding protein-related protein (ORP) superfamily that inhibits phosphatidylinositol transfer protein (Sec14)-dependent membrane trafficking through the trans-Golgi (TGN)/endosomal network. We now report that Kes1, and select other ORPs, execute cell-cycle control activities as functionally non-redundant inhibitors of the G 1 /S transition when cells confront nutrient-poor environments and promote replicative aging. Kes1-dependent cell-cycle regulation requires the Greatwall/MASTL kinase ortholog Rim15, and is opposed by Sec14 activity in a mechanism independent of Kes1/Sec14 bulk membrane-trafficking functions. Moreover, the data identify Kes1 as a non-histone target for NuA4 through which this lysine acetyltransferase co-modulates membrane-trafficking and cell-cycle activities. We propose the Sec14/Kes1 lipid-exchange protein pair constitutes part of the mechanism for integrating TGN/endosomal lipid signaling with cell-cycle progression and hypothesize that ORPs define a family of stage-specific cell-cycle control factors that execute tumor-suppressor-like functions. Huang et al. demonstrate the yeast oxysterol-binding protein (ORP) homolog Kes1, and other ORPs, are inhibitors of the G 1 /S transition. They show that Kes1 is a non-histone target for the NuA4 lysine acetyltransferase and participates in a phosphatidylinositol-4-phopshate-dependent mechanism for integrating TGN/endosomal lipid signaling with cell-cycle progression. 2018 Journal Article http://hdl.handle.net/20.500.11937/65893 10.1016/j.devcel.2017.12.026 Cell Press restricted
spellingShingle Huang, J.
Mousley, Carl
Dacquay, L.
Maitra, N.
Drin, G.
He, C.
Ridgway, N.
Tripathi, A.
Kennedy, M.
Kennedy, B.
Liu, W.
Baetz, K.
Polymenis, M.
Bankaitis, V.
A Lipid Transfer Protein Signaling Axis Exerts Dual Control of Cell-Cycle and Membrane Trafficking Systems
title A Lipid Transfer Protein Signaling Axis Exerts Dual Control of Cell-Cycle and Membrane Trafficking Systems
title_full A Lipid Transfer Protein Signaling Axis Exerts Dual Control of Cell-Cycle and Membrane Trafficking Systems
title_fullStr A Lipid Transfer Protein Signaling Axis Exerts Dual Control of Cell-Cycle and Membrane Trafficking Systems
title_full_unstemmed A Lipid Transfer Protein Signaling Axis Exerts Dual Control of Cell-Cycle and Membrane Trafficking Systems
title_short A Lipid Transfer Protein Signaling Axis Exerts Dual Control of Cell-Cycle and Membrane Trafficking Systems
title_sort lipid transfer protein signaling axis exerts dual control of cell-cycle and membrane trafficking systems
url http://hdl.handle.net/20.500.11937/65893