Animal Models of Alzheimer's Disease
© 2017 Elsevier Inc. All rights reserved. Alzheimer's disease is a major and increasing burden on families, communities, and national health budgets. Despite intensive and extended research there is still widespread debate about its cause(s) and no effective treatments exist. Familial (inherite...
| Main Authors: | , , , , , |
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| Format: | Book Chapter |
| Published: |
2017
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| Online Access: | http://hdl.handle.net/20.500.11937/65881 |
| _version_ | 1848761224110538752 |
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| author | Newman, M. Kretzschmar, D. Khan, I. Chen, M. Verdile, Giuseppe Lardelli, M. |
| author_facet | Newman, M. Kretzschmar, D. Khan, I. Chen, M. Verdile, Giuseppe Lardelli, M. |
| author_sort | Newman, M. |
| building | Curtin Institutional Repository |
| collection | Online Access |
| description | © 2017 Elsevier Inc. All rights reserved. Alzheimer's disease is a major and increasing burden on families, communities, and national health budgets. Despite intensive and extended research there is still widespread debate about its cause(s) and no effective treatments exist. Familial (inherited, mainly early onset) and sporadic (mainly late onset) forms of the disease exist and it is uncertain to what extent they are related. Transgenic mouse models have dominated the investigation of this disease but their validity can be questioned. Numerous alternative models exist that can provide valuable information on the molecular and cellular basis of Alzheimer's disease. In this chapter we review the various invertebrate, nonmammalian vertebrate, and mammalian models and how these have been used to investigate this disease. We examine the strengths and weaknesses of these various model systems. Of course, animal models never completely reflect the true nature of a human disease but progress in understanding and finding preventative and ameliorative treatments for Alzheimer's disease is hindered by the lack of a convincing hypothesis for the cause of this complex condition. |
| first_indexed | 2025-11-14T10:28:16Z |
| format | Book Chapter |
| id | curtin-20.500.11937-65881 |
| institution | Curtin University Malaysia |
| institution_category | Local University |
| last_indexed | 2025-11-14T10:28:16Z |
| publishDate | 2017 |
| recordtype | eprints |
| repository_type | Digital Repository |
| spelling | curtin-20.500.11937-658812018-02-19T08:06:42Z Animal Models of Alzheimer's Disease Newman, M. Kretzschmar, D. Khan, I. Chen, M. Verdile, Giuseppe Lardelli, M. © 2017 Elsevier Inc. All rights reserved. Alzheimer's disease is a major and increasing burden on families, communities, and national health budgets. Despite intensive and extended research there is still widespread debate about its cause(s) and no effective treatments exist. Familial (inherited, mainly early onset) and sporadic (mainly late onset) forms of the disease exist and it is uncertain to what extent they are related. Transgenic mouse models have dominated the investigation of this disease but their validity can be questioned. Numerous alternative models exist that can provide valuable information on the molecular and cellular basis of Alzheimer's disease. In this chapter we review the various invertebrate, nonmammalian vertebrate, and mammalian models and how these have been used to investigate this disease. We examine the strengths and weaknesses of these various model systems. Of course, animal models never completely reflect the true nature of a human disease but progress in understanding and finding preventative and ameliorative treatments for Alzheimer's disease is hindered by the lack of a convincing hypothesis for the cause of this complex condition. 2017 Book Chapter http://hdl.handle.net/20.500.11937/65881 10.1016/B978-0-12-809468-6.00040-1 restricted |
| spellingShingle | Newman, M. Kretzschmar, D. Khan, I. Chen, M. Verdile, Giuseppe Lardelli, M. Animal Models of Alzheimer's Disease |
| title | Animal Models of Alzheimer's Disease |
| title_full | Animal Models of Alzheimer's Disease |
| title_fullStr | Animal Models of Alzheimer's Disease |
| title_full_unstemmed | Animal Models of Alzheimer's Disease |
| title_short | Animal Models of Alzheimer's Disease |
| title_sort | animal models of alzheimer's disease |
| url | http://hdl.handle.net/20.500.11937/65881 |