The role of chitosan on oral delivery of peptide-loaded nanoparticle formulation.
Therapeutic peptides are conventionally administered via subcutaneous injection. Chitosan-based nanoparticles are gaining increased attention for their ability to serve as a carrier for oral delivery of peptides and vaccination. They offered superior biocompatibiltiy, controlled drug release profile...
| Main Authors: | , , |
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| Format: | Journal Article |
| Published: |
informa UK Ltd
2017
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| Online Access: | http://hdl.handle.net/20.500.11937/65862 |
| _version_ | 1848761220101832704 |
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| author | Wong, C. Al-Salami, Hani Dass, C. |
| author_facet | Wong, C. Al-Salami, Hani Dass, C. |
| author_sort | Wong, C. |
| building | Curtin Institutional Repository |
| collection | Online Access |
| description | Therapeutic peptides are conventionally administered via subcutaneous injection. Chitosan-based nanoparticles are gaining increased attention for their ability to serve as a carrier for oral delivery of peptides and vaccination. They offered superior biocompatibiltiy, controlled drug release profile and facilitated gastrointestinal (GI) absorption. The encapsulated peptides can withstand enzymatic degradation and various pH. Chitosan-based nanoparticles can also be modified by ligand conjugation to the surface of nanoparticle for transcellular absorption and specific-targeted delivery of macromolecules to the tissue of interest. Current research suggests that chitosan-based nanoparticles can deliver therapeutic peptide for the treatment of several medical conditions such as diabetes, bacterial infection and cancer. This review summarises the role of chitosan in oral nanoparticle delivery and identifies the clinical application of peptide-loaded chitosan-based nanoparticles. |
| first_indexed | 2025-11-14T10:28:12Z |
| format | Journal Article |
| id | curtin-20.500.11937-65862 |
| institution | Curtin University Malaysia |
| institution_category | Local University |
| last_indexed | 2025-11-14T10:28:12Z |
| publishDate | 2017 |
| publisher | informa UK Ltd |
| recordtype | eprints |
| repository_type | Digital Repository |
| spelling | curtin-20.500.11937-658622018-02-19T08:06:17Z The role of chitosan on oral delivery of peptide-loaded nanoparticle formulation. Wong, C. Al-Salami, Hani Dass, C. Therapeutic peptides are conventionally administered via subcutaneous injection. Chitosan-based nanoparticles are gaining increased attention for their ability to serve as a carrier for oral delivery of peptides and vaccination. They offered superior biocompatibiltiy, controlled drug release profile and facilitated gastrointestinal (GI) absorption. The encapsulated peptides can withstand enzymatic degradation and various pH. Chitosan-based nanoparticles can also be modified by ligand conjugation to the surface of nanoparticle for transcellular absorption and specific-targeted delivery of macromolecules to the tissue of interest. Current research suggests that chitosan-based nanoparticles can deliver therapeutic peptide for the treatment of several medical conditions such as diabetes, bacterial infection and cancer. This review summarises the role of chitosan in oral nanoparticle delivery and identifies the clinical application of peptide-loaded chitosan-based nanoparticles. 2017 Journal Article http://hdl.handle.net/20.500.11937/65862 10.1080/1061186X.2017.1400552 informa UK Ltd restricted |
| spellingShingle | Wong, C. Al-Salami, Hani Dass, C. The role of chitosan on oral delivery of peptide-loaded nanoparticle formulation. |
| title | The role of chitosan on oral delivery of peptide-loaded nanoparticle formulation. |
| title_full | The role of chitosan on oral delivery of peptide-loaded nanoparticle formulation. |
| title_fullStr | The role of chitosan on oral delivery of peptide-loaded nanoparticle formulation. |
| title_full_unstemmed | The role of chitosan on oral delivery of peptide-loaded nanoparticle formulation. |
| title_short | The role of chitosan on oral delivery of peptide-loaded nanoparticle formulation. |
| title_sort | role of chitosan on oral delivery of peptide-loaded nanoparticle formulation. |
| url | http://hdl.handle.net/20.500.11937/65862 |