4-Phenethylthio-2-phenylpyrazolo[1,5-a][1,3,5]triazin-7(6H)-one
© 2017 by the authors. Licensee MDPI, Basel, Switzerland. Exploring the pharmacologically important pyrazolo[1,5-a][1,3,5] triazin-7(6H)-one scaffold for the construction of new bioactive compounds, we developed a synthesis of 4-phenethylthio-2- phenylpyrazolo[1,5-a][1,3,5] triazin-7(6H)-one (4) via...
| Main Authors: | , , , , , |
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| Format: | Journal Article |
| Published: |
2017
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| Online Access: | http://hdl.handle.net/20.500.11937/65783 |
| _version_ | 1848761203255410688 |
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| author | Smolnikov, S. Gorgopina, E. Lezhnyova, V. Ong, G. Chui, W. Dolzhenko, Anton |
| author_facet | Smolnikov, S. Gorgopina, E. Lezhnyova, V. Ong, G. Chui, W. Dolzhenko, Anton |
| author_sort | Smolnikov, S. |
| building | Curtin Institutional Repository |
| collection | Online Access |
| description | © 2017 by the authors. Licensee MDPI, Basel, Switzerland. Exploring the pharmacologically important pyrazolo[1,5-a][1,3,5] triazin-7(6H)-one scaffold for the construction of new bioactive compounds, we developed a synthesis of 4-phenethylthio-2- phenylpyrazolo[1,5-a][1,3,5] triazin-7(6H)-one (4) via S-alkylation of 2-phenyl-4-thioxopyrazolo [1,5-a][1,3,5] triazine-7(6H)-one (3), prepared by the double ring closure of pyrazole and triazine rings upon the treatment of 1-cyanoacetyl-4-benzoylthiosemicarbazide (2) with alkali. The antiproliferative activity of 4 against human lung cancer (A549) and human breast cancer (MDA-MB231) cell lines was investigated. Compound 4 was found to be more active against lung cancer cells t han breast cancer cells. |
| first_indexed | 2025-11-14T10:27:56Z |
| format | Journal Article |
| id | curtin-20.500.11937-65783 |
| institution | Curtin University Malaysia |
| institution_category | Local University |
| last_indexed | 2025-11-14T10:27:56Z |
| publishDate | 2017 |
| recordtype | eprints |
| repository_type | Digital Repository |
| spelling | curtin-20.500.11937-657832019-07-23T03:02:07Z 4-Phenethylthio-2-phenylpyrazolo[1,5-a][1,3,5]triazin-7(6H)-one Smolnikov, S. Gorgopina, E. Lezhnyova, V. Ong, G. Chui, W. Dolzhenko, Anton © 2017 by the authors. Licensee MDPI, Basel, Switzerland. Exploring the pharmacologically important pyrazolo[1,5-a][1,3,5] triazin-7(6H)-one scaffold for the construction of new bioactive compounds, we developed a synthesis of 4-phenethylthio-2- phenylpyrazolo[1,5-a][1,3,5] triazin-7(6H)-one (4) via S-alkylation of 2-phenyl-4-thioxopyrazolo [1,5-a][1,3,5] triazine-7(6H)-one (3), prepared by the double ring closure of pyrazole and triazine rings upon the treatment of 1-cyanoacetyl-4-benzoylthiosemicarbazide (2) with alkali. The antiproliferative activity of 4 against human lung cancer (A549) and human breast cancer (MDA-MB231) cell lines was investigated. Compound 4 was found to be more active against lung cancer cells t han breast cancer cells. 2017 Journal Article http://hdl.handle.net/20.500.11937/65783 10.3390/M970 unknown |
| spellingShingle | Smolnikov, S. Gorgopina, E. Lezhnyova, V. Ong, G. Chui, W. Dolzhenko, Anton 4-Phenethylthio-2-phenylpyrazolo[1,5-a][1,3,5]triazin-7(6H)-one |
| title | 4-Phenethylthio-2-phenylpyrazolo[1,5-a][1,3,5]triazin-7(6H)-one |
| title_full | 4-Phenethylthio-2-phenylpyrazolo[1,5-a][1,3,5]triazin-7(6H)-one |
| title_fullStr | 4-Phenethylthio-2-phenylpyrazolo[1,5-a][1,3,5]triazin-7(6H)-one |
| title_full_unstemmed | 4-Phenethylthio-2-phenylpyrazolo[1,5-a][1,3,5]triazin-7(6H)-one |
| title_short | 4-Phenethylthio-2-phenylpyrazolo[1,5-a][1,3,5]triazin-7(6H)-one |
| title_sort | 4-phenethylthio-2-phenylpyrazolo[1,5-a][1,3,5]triazin-7(6h)-one |
| url | http://hdl.handle.net/20.500.11937/65783 |