Case-control study to assess the association between colorectal cancer and selected occupational agents using INTEROCC job exposure matrix.
BACKGROUND: Colorectal cancer is the third most prevalent cancer in the world and is twice as common in developed countries when compared with low-income and middle-income countries. Few occupational risk factors for colorectal cancer have been identified. This case-control study aimed to assess the...
| Main Authors: | , , , , , |
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| Format: | Journal Article |
| Published: |
2017
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| Online Access: | http://hdl.handle.net/20.500.11937/65689 |
| _version_ | 1848761182570151936 |
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| author | El-Zaemey, S. Anand, T. Heyworth, J. Boyle, T. van Tongeren, M. Fritschi, Lin |
| author_facet | El-Zaemey, S. Anand, T. Heyworth, J. Boyle, T. van Tongeren, M. Fritschi, Lin |
| author_sort | El-Zaemey, S. |
| building | Curtin Institutional Repository |
| collection | Online Access |
| description | BACKGROUND: Colorectal cancer is the third most prevalent cancer in the world and is twice as common in developed countries when compared with low-income and middle-income countries. Few occupational risk factors for colorectal cancer have been identified. This case-control study aimed to assess the association between colorectal cancer and occupational exposure to selected solvents, combustion products, metals, dusts and other agents. METHODS: Cases (n=918) were enrolled from the Western Australian Cancer Registry from June 2005 to August 2007. Controls (n=1021) were randomly selected from the Western Australian electoral roll. We collected lifetime occupational history from cases and controls, in addition to their demographic and lifestyle characteristics. We applied the INTEROCC job exposure matrix to convert the occupational history to occupational exposure for 18 selected agents. Three exposure indices were developed: (1) exposed versus non-exposed; (2) lifetime cumulative exposure; and (3) total duration of exposure. The associations between colorectal cancer and the selected agents were estimated using logistic regression models adjusting for sex and age. RESULTS: None of the 18 selected agents showed an association with colorectal cancer. No dose-response relationships with lifetime cumulative exposure or duration of exposure were observed. CONCLUSION: There was no evidence to suggest that occupational exposure to 18 selected agents increased the risk of colorectal cancer. |
| first_indexed | 2025-11-14T10:27:36Z |
| format | Journal Article |
| id | curtin-20.500.11937-65689 |
| institution | Curtin University Malaysia |
| institution_category | Local University |
| last_indexed | 2025-11-14T10:27:36Z |
| publishDate | 2017 |
| recordtype | eprints |
| repository_type | Digital Repository |
| spelling | curtin-20.500.11937-656892020-06-02T01:09:57Z Case-control study to assess the association between colorectal cancer and selected occupational agents using INTEROCC job exposure matrix. El-Zaemey, S. Anand, T. Heyworth, J. Boyle, T. van Tongeren, M. Fritschi, Lin BACKGROUND: Colorectal cancer is the third most prevalent cancer in the world and is twice as common in developed countries when compared with low-income and middle-income countries. Few occupational risk factors for colorectal cancer have been identified. This case-control study aimed to assess the association between colorectal cancer and occupational exposure to selected solvents, combustion products, metals, dusts and other agents. METHODS: Cases (n=918) were enrolled from the Western Australian Cancer Registry from June 2005 to August 2007. Controls (n=1021) were randomly selected from the Western Australian electoral roll. We collected lifetime occupational history from cases and controls, in addition to their demographic and lifestyle characteristics. We applied the INTEROCC job exposure matrix to convert the occupational history to occupational exposure for 18 selected agents. Three exposure indices were developed: (1) exposed versus non-exposed; (2) lifetime cumulative exposure; and (3) total duration of exposure. The associations between colorectal cancer and the selected agents were estimated using logistic regression models adjusting for sex and age. RESULTS: None of the 18 selected agents showed an association with colorectal cancer. No dose-response relationships with lifetime cumulative exposure or duration of exposure were observed. CONCLUSION: There was no evidence to suggest that occupational exposure to 18 selected agents increased the risk of colorectal cancer. 2017 Journal Article http://hdl.handle.net/20.500.11937/65689 10.1136/oemed-2017-104795 restricted |
| spellingShingle | El-Zaemey, S. Anand, T. Heyworth, J. Boyle, T. van Tongeren, M. Fritschi, Lin Case-control study to assess the association between colorectal cancer and selected occupational agents using INTEROCC job exposure matrix. |
| title | Case-control study to assess the association between colorectal cancer and selected occupational agents using INTEROCC job exposure matrix. |
| title_full | Case-control study to assess the association between colorectal cancer and selected occupational agents using INTEROCC job exposure matrix. |
| title_fullStr | Case-control study to assess the association between colorectal cancer and selected occupational agents using INTEROCC job exposure matrix. |
| title_full_unstemmed | Case-control study to assess the association between colorectal cancer and selected occupational agents using INTEROCC job exposure matrix. |
| title_short | Case-control study to assess the association between colorectal cancer and selected occupational agents using INTEROCC job exposure matrix. |
| title_sort | case-control study to assess the association between colorectal cancer and selected occupational agents using interocc job exposure matrix. |
| url | http://hdl.handle.net/20.500.11937/65689 |