Supplementary motor area—primary motor cortex facilitation in younger but not older adults
© 2018 Elsevier Inc. Growing evidence implicates a decline in white matter integrity in the age-related decline in motor control. Functional neuroimaging studies show significant associations between functional connectivity in the cortical motor network, including the supplementary motor area (SMA),...
| Main Authors: | , , , , , |
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| Format: | Journal Article |
| Published: |
Elsevier Inc.
2018
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| Online Access: | http://hdl.handle.net/20.500.11937/65639 |
| _version_ | 1848761171853705216 |
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| author | Green, P. Ridding, M. Hill, Keith Semmler, J. Drummond, P. Vallence, A. |
| author_facet | Green, P. Ridding, M. Hill, Keith Semmler, J. Drummond, P. Vallence, A. |
| author_sort | Green, P. |
| building | Curtin Institutional Repository |
| collection | Online Access |
| description | © 2018 Elsevier Inc. Growing evidence implicates a decline in white matter integrity in the age-related decline in motor control. Functional neuroimaging studies show significant associations between functional connectivity in the cortical motor network, including the supplementary motor area (SMA), and motor performance. Dual-coil transcranial magnetic stimulation studies show facilitatory connections between SMA and the primary motor cortex (M1) in younger adults. Here, we investigated whether SMA-M1 facilitation is affected by age and whether the strength of SMA-M1 facilitation is associated with bilateral motor control. Dual-coil transcranial magnetic stimulation was used to measure SMA-M1 connectivity in younger (N = 20) and older adults (N = 18), and bilateral motor control was measured with the assembly subtest of the Purdue Pegboard and clinical measures of dynamic balance. SMA-M1 facilitation was seen in younger but not older adults, and a significant positive association was found between SMA-M1 facilitation and bimanual performance. These results show that SMA-M1 facilitation is reduced in older adults compared to younger adults and provide evidence of the functional importance of SMA-M1 facilitation. |
| first_indexed | 2025-11-14T10:27:26Z |
| format | Journal Article |
| id | curtin-20.500.11937-65639 |
| institution | Curtin University Malaysia |
| institution_category | Local University |
| last_indexed | 2025-11-14T10:27:26Z |
| publishDate | 2018 |
| publisher | Elsevier Inc. |
| recordtype | eprints |
| repository_type | Digital Repository |
| spelling | curtin-20.500.11937-656392018-02-19T08:06:31Z Supplementary motor area—primary motor cortex facilitation in younger but not older adults Green, P. Ridding, M. Hill, Keith Semmler, J. Drummond, P. Vallence, A. © 2018 Elsevier Inc. Growing evidence implicates a decline in white matter integrity in the age-related decline in motor control. Functional neuroimaging studies show significant associations between functional connectivity in the cortical motor network, including the supplementary motor area (SMA), and motor performance. Dual-coil transcranial magnetic stimulation studies show facilitatory connections between SMA and the primary motor cortex (M1) in younger adults. Here, we investigated whether SMA-M1 facilitation is affected by age and whether the strength of SMA-M1 facilitation is associated with bilateral motor control. Dual-coil transcranial magnetic stimulation was used to measure SMA-M1 connectivity in younger (N = 20) and older adults (N = 18), and bilateral motor control was measured with the assembly subtest of the Purdue Pegboard and clinical measures of dynamic balance. SMA-M1 facilitation was seen in younger but not older adults, and a significant positive association was found between SMA-M1 facilitation and bimanual performance. These results show that SMA-M1 facilitation is reduced in older adults compared to younger adults and provide evidence of the functional importance of SMA-M1 facilitation. 2018 Journal Article http://hdl.handle.net/20.500.11937/65639 10.1016/j.neurobiolaging.2017.12.016 Elsevier Inc. restricted |
| spellingShingle | Green, P. Ridding, M. Hill, Keith Semmler, J. Drummond, P. Vallence, A. Supplementary motor area—primary motor cortex facilitation in younger but not older adults |
| title | Supplementary motor area—primary motor cortex facilitation in younger but not older adults |
| title_full | Supplementary motor area—primary motor cortex facilitation in younger but not older adults |
| title_fullStr | Supplementary motor area—primary motor cortex facilitation in younger but not older adults |
| title_full_unstemmed | Supplementary motor area—primary motor cortex facilitation in younger but not older adults |
| title_short | Supplementary motor area—primary motor cortex facilitation in younger but not older adults |
| title_sort | supplementary motor area—primary motor cortex facilitation in younger but not older adults |
| url | http://hdl.handle.net/20.500.11937/65639 |