The role of Wnt signalling in angiogenesis
Angiogenesis is a normal biological process wherein new blood vessels form from the growth of pre-existing blood vessels. Preventing angiogenesis in solid tumours by targeting pro-angiogenic factors including vascular endothelial growth factor (VEGF), angiopoietin-1 (Ang-1), basic fibroblast growth...
| Main Authors: | , , , , , , , |
|---|---|
| Format: | Journal Article |
| Published: |
The Australasian Association of Clinical Biochemists
2017
|
| Online Access: | http://hdl.handle.net/20.500.11937/65569 |
| _version_ | 1848761157956927488 |
|---|---|
| author | Olsen, J. Pohl, Sebastian Deshmukh, Abhijeet Visweswaran, Malini Ward, Natalie Arfuso, Frank Agostino, Mark Dharmarajan, Arunasalam |
| author_facet | Olsen, J. Pohl, Sebastian Deshmukh, Abhijeet Visweswaran, Malini Ward, Natalie Arfuso, Frank Agostino, Mark Dharmarajan, Arunasalam |
| author_sort | Olsen, J. |
| building | Curtin Institutional Repository |
| collection | Online Access |
| description | Angiogenesis is a normal biological process wherein new blood vessels form from the growth of pre-existing blood vessels. Preventing angiogenesis in solid tumours by targeting pro-angiogenic factors including vascular endothelial growth factor (VEGF), angiopoietin-1 (Ang-1), basic fibroblast growth factor (bFGF), hepatocyte growth factor, and platelet-derived growth factor (PDGF) is currently under investigation for cancer treatment. Concurrently targeting the cell signalling pathways involved in the transcriptional and post-translational regulation of t hese factors may provide positive therapeutic results. One such pathway is the Wnt signalling pathway. Wnt was first discovered in mice infected with mouse mammary tumour virus, and has been crucial in improving our understanding of oncogenesis and development. In this review, we summarise molecular and cellular aspects of the importance of Wnt signalling to angiogenesis, including ß-catenin-dependent mechanisms of angiogenic promotion, as well as the study of Wnt antagonists, such as the secreted frizzled-related protein family (SFRPs) which have been shown to inhibit angiogenesis. The growing understanding of the underlying complexity of the biochemical pathways mediating angiogenesis is critical to the identification of new molecular targets for therapeutic applications. |
| first_indexed | 2025-11-14T10:27:13Z |
| format | Journal Article |
| id | curtin-20.500.11937-65569 |
| institution | Curtin University Malaysia |
| institution_category | Local University |
| last_indexed | 2025-11-14T10:27:13Z |
| publishDate | 2017 |
| publisher | The Australasian Association of Clinical Biochemists |
| recordtype | eprints |
| repository_type | Digital Repository |
| spelling | curtin-20.500.11937-655692018-04-17T05:55:00Z The role of Wnt signalling in angiogenesis Olsen, J. Pohl, Sebastian Deshmukh, Abhijeet Visweswaran, Malini Ward, Natalie Arfuso, Frank Agostino, Mark Dharmarajan, Arunasalam Angiogenesis is a normal biological process wherein new blood vessels form from the growth of pre-existing blood vessels. Preventing angiogenesis in solid tumours by targeting pro-angiogenic factors including vascular endothelial growth factor (VEGF), angiopoietin-1 (Ang-1), basic fibroblast growth factor (bFGF), hepatocyte growth factor, and platelet-derived growth factor (PDGF) is currently under investigation for cancer treatment. Concurrently targeting the cell signalling pathways involved in the transcriptional and post-translational regulation of t hese factors may provide positive therapeutic results. One such pathway is the Wnt signalling pathway. Wnt was first discovered in mice infected with mouse mammary tumour virus, and has been crucial in improving our understanding of oncogenesis and development. In this review, we summarise molecular and cellular aspects of the importance of Wnt signalling to angiogenesis, including ß-catenin-dependent mechanisms of angiogenic promotion, as well as the study of Wnt antagonists, such as the secreted frizzled-related protein family (SFRPs) which have been shown to inhibit angiogenesis. The growing understanding of the underlying complexity of the biochemical pathways mediating angiogenesis is critical to the identification of new molecular targets for therapeutic applications. 2017 Journal Article http://hdl.handle.net/20.500.11937/65569 The Australasian Association of Clinical Biochemists restricted |
| spellingShingle | Olsen, J. Pohl, Sebastian Deshmukh, Abhijeet Visweswaran, Malini Ward, Natalie Arfuso, Frank Agostino, Mark Dharmarajan, Arunasalam The role of Wnt signalling in angiogenesis |
| title | The role of Wnt signalling in angiogenesis |
| title_full | The role of Wnt signalling in angiogenesis |
| title_fullStr | The role of Wnt signalling in angiogenesis |
| title_full_unstemmed | The role of Wnt signalling in angiogenesis |
| title_short | The role of Wnt signalling in angiogenesis |
| title_sort | role of wnt signalling in angiogenesis |
| url | http://hdl.handle.net/20.500.11937/65569 |