Tissue Factor Pathway Inhibitor: Then and Now
Tissue factor pathway inhibitor (TFPI) is the major physiological regulator of tissue factor (TF)-induced blood coagulation. TFPI inhibits the TF-activated factor VII (FVIIa) complex in an activated factor X (FXa)-dependent manner, helping to control thrombin generation and ultimately fibrin formati...
| Main Authors: | , |
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| Format: | Journal Article |
| Published: |
Thieme Medical Publishers, Inc.
2014
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| Online Access: | http://hdl.handle.net/20.500.11937/6509 |
| _version_ | 1848745095541555200 |
|---|---|
| author | Ellery, Paul Adams, M. |
| author_facet | Ellery, Paul Adams, M. |
| author_sort | Ellery, Paul |
| building | Curtin Institutional Repository |
| collection | Online Access |
| description | Tissue factor pathway inhibitor (TFPI) is the major physiological regulator of tissue factor (TF)-induced blood coagulation. TFPI inhibits the TF-activated factor VII (FVIIa) complex in an activated factor X (FXa)-dependent manner, helping to control thrombin generation and ultimately fibrin formation. The importance of TFPI is demonstrated in models of hemophilia where lower levels of FVIII or FIX are insufficient to overcome its inhibitory effect, resulting in a bleeding phenotype. There are two major isoforms in vivo; TFPI contains three Kunitz-type inhibitory domains (designated K1, K2, and K3), is secreted by endothelial cells and requires protein S to enhance its anticoagulant activity. In contrast, TFPIß contains only the K1 and K2 domains, but it is attached to the endothelial surface via a glycosylphosphatidylinositol anchor. This review will initially provide a brief history of the major discoveries related to TFPI, and then discuss new insights into the physiology of TFPI, including updates on its association with protein S and FV, as well as the current understanding of its association with disease. |
| first_indexed | 2025-11-14T06:11:55Z |
| format | Journal Article |
| id | curtin-20.500.11937-6509 |
| institution | Curtin University Malaysia |
| institution_category | Local University |
| last_indexed | 2025-11-14T06:11:55Z |
| publishDate | 2014 |
| publisher | Thieme Medical Publishers, Inc. |
| recordtype | eprints |
| repository_type | Digital Repository |
| spelling | curtin-20.500.11937-65092017-09-13T14:41:38Z Tissue Factor Pathway Inhibitor: Then and Now Ellery, Paul Adams, M. Tissue factor pathway inhibitor (TFPI) is the major physiological regulator of tissue factor (TF)-induced blood coagulation. TFPI inhibits the TF-activated factor VII (FVIIa) complex in an activated factor X (FXa)-dependent manner, helping to control thrombin generation and ultimately fibrin formation. The importance of TFPI is demonstrated in models of hemophilia where lower levels of FVIII or FIX are insufficient to overcome its inhibitory effect, resulting in a bleeding phenotype. There are two major isoforms in vivo; TFPI contains three Kunitz-type inhibitory domains (designated K1, K2, and K3), is secreted by endothelial cells and requires protein S to enhance its anticoagulant activity. In contrast, TFPIß contains only the K1 and K2 domains, but it is attached to the endothelial surface via a glycosylphosphatidylinositol anchor. This review will initially provide a brief history of the major discoveries related to TFPI, and then discuss new insights into the physiology of TFPI, including updates on its association with protein S and FV, as well as the current understanding of its association with disease. 2014 Journal Article http://hdl.handle.net/20.500.11937/6509 10.1055/s-0034-1395153 Thieme Medical Publishers, Inc. restricted |
| spellingShingle | Ellery, Paul Adams, M. Tissue Factor Pathway Inhibitor: Then and Now |
| title | Tissue Factor Pathway Inhibitor: Then and Now |
| title_full | Tissue Factor Pathway Inhibitor: Then and Now |
| title_fullStr | Tissue Factor Pathway Inhibitor: Then and Now |
| title_full_unstemmed | Tissue Factor Pathway Inhibitor: Then and Now |
| title_short | Tissue Factor Pathway Inhibitor: Then and Now |
| title_sort | tissue factor pathway inhibitor: then and now |
| url | http://hdl.handle.net/20.500.11937/6509 |