Diagnostic value of SPECT, PET and PET/CT in the diagnosis of coronary artery disease: A systematic review
Purpose: The purpose of the study was to investigate the diagnostic value of SPECT, PET and PET/CT in thediagnosis of coronary artery disease, based on a systematic review. Material and Methods: A search of PubMed/Medline and Sciencedirect databases in the English-language literature published over...
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| Format: | Journal Article |
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University of Malaya
2011
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| Online Access: | http://hdl.handle.net/20.500.11937/6452 |
| _version_ | 1848745079940841472 |
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| author | Al Moudi, M. Sun, Zhonghua Lenzo, N. |
| author_facet | Al Moudi, M. Sun, Zhonghua Lenzo, N. |
| author_sort | Al Moudi, M. |
| building | Curtin Institutional Repository |
| collection | Online Access |
| description | Purpose: The purpose of the study was to investigate the diagnostic value of SPECT, PET and PET/CT in thediagnosis of coronary artery disease, based on a systematic review. Material and Methods: A search of PubMed/Medline and Sciencedirect databases in the English-language literature published over the last 24 years was performed. Only studies with at least 10 patients comparing SPECT, PET or combined PET/CT with invasive coronary angiography in the diagnosis of coronary artery disease (50% stenosis) were included for analysis. Sensitivities and specificities estimates pooled across studies were analysed using a Chisquare test.Results: Twenty-five studies met the selection criteria and were included for the analysis. Ten studies were performed with SPECT alone; while another six studies were performed with PET alone. Five studies were carried outwith both PET and SPECT modalities, and the remaining four studies were investigated with integrated PET-CT. Themean value of sensitivity, specificity and accuracy of these imaging modalities for the diagnosis of coronary artery disease was 82% (95%CI: 76 to 88), 76% (95%CI: 70 to 82) and 83% (95%CI: 77 to 89) for SPECT; 91% (95%CI: 85to 97), 89% (95%CI: 83 to 95) and 89% (95%CI: 83 to 95) for PET; and 85% (95%CI: 79 to 90), 83% (95%CI: 77 to 89)and 88% (95%CI: 82 to 94) for PET/CT, respectively. The diagnostic accuracy of these imaging modalities wasdependent on the radiotracers used in these studies, with ammonia resulting in the highest diagnostic value.Conclusion: Our review shows that PET has high diagnostic value for diagnosing coronary artery disease, and this indicates that it is a valuable technique for both detection and prediction of coronary artery disease. |
| first_indexed | 2025-11-14T06:11:40Z |
| format | Journal Article |
| id | curtin-20.500.11937-6452 |
| institution | Curtin University Malaysia |
| institution_category | Local University |
| last_indexed | 2025-11-14T06:11:40Z |
| publishDate | 2011 |
| publisher | University of Malaya |
| recordtype | eprints |
| repository_type | Digital Repository |
| spelling | curtin-20.500.11937-64522020-05-12T02:13:53Z Diagnostic value of SPECT, PET and PET/CT in the diagnosis of coronary artery disease: A systematic review Al Moudi, M. Sun, Zhonghua Lenzo, N. Coronary artery disease single photon emission computed tomography computed tomography positron emission tomography diagnostic value Purpose: The purpose of the study was to investigate the diagnostic value of SPECT, PET and PET/CT in thediagnosis of coronary artery disease, based on a systematic review. Material and Methods: A search of PubMed/Medline and Sciencedirect databases in the English-language literature published over the last 24 years was performed. Only studies with at least 10 patients comparing SPECT, PET or combined PET/CT with invasive coronary angiography in the diagnosis of coronary artery disease (50% stenosis) were included for analysis. Sensitivities and specificities estimates pooled across studies were analysed using a Chisquare test.Results: Twenty-five studies met the selection criteria and were included for the analysis. Ten studies were performed with SPECT alone; while another six studies were performed with PET alone. Five studies were carried outwith both PET and SPECT modalities, and the remaining four studies were investigated with integrated PET-CT. Themean value of sensitivity, specificity and accuracy of these imaging modalities for the diagnosis of coronary artery disease was 82% (95%CI: 76 to 88), 76% (95%CI: 70 to 82) and 83% (95%CI: 77 to 89) for SPECT; 91% (95%CI: 85to 97), 89% (95%CI: 83 to 95) and 89% (95%CI: 83 to 95) for PET; and 85% (95%CI: 79 to 90), 83% (95%CI: 77 to 89)and 88% (95%CI: 82 to 94) for PET/CT, respectively. The diagnostic accuracy of these imaging modalities wasdependent on the radiotracers used in these studies, with ammonia resulting in the highest diagnostic value.Conclusion: Our review shows that PET has high diagnostic value for diagnosing coronary artery disease, and this indicates that it is a valuable technique for both detection and prediction of coronary artery disease. 2011 Journal Article http://hdl.handle.net/20.500.11937/6452 10.2349/biij.7.2.e9 University of Malaya fulltext |
| spellingShingle | Coronary artery disease single photon emission computed tomography computed tomography positron emission tomography diagnostic value Al Moudi, M. Sun, Zhonghua Lenzo, N. Diagnostic value of SPECT, PET and PET/CT in the diagnosis of coronary artery disease: A systematic review |
| title | Diagnostic value of SPECT, PET and PET/CT in the diagnosis of coronary artery disease: A systematic review |
| title_full | Diagnostic value of SPECT, PET and PET/CT in the diagnosis of coronary artery disease: A systematic review |
| title_fullStr | Diagnostic value of SPECT, PET and PET/CT in the diagnosis of coronary artery disease: A systematic review |
| title_full_unstemmed | Diagnostic value of SPECT, PET and PET/CT in the diagnosis of coronary artery disease: A systematic review |
| title_short | Diagnostic value of SPECT, PET and PET/CT in the diagnosis of coronary artery disease: A systematic review |
| title_sort | diagnostic value of spect, pet and pet/ct in the diagnosis of coronary artery disease: a systematic review |
| topic | Coronary artery disease single photon emission computed tomography computed tomography positron emission tomography diagnostic value |
| url | http://hdl.handle.net/20.500.11937/6452 |