Replication of staphylococcal resistance plasmids
© 2017 Kwong, Ramsay, Jensen and Firth. The currently widespread and increasing prevalence of resistant bacterial pathogens is a significant medical problem. In clinical strains of staphylococci, the genetic determinants that confer resistance to antimicrobial agents are often located on mobile elem...
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| Format: | Journal Article |
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Frontiers Research Foundation
2017
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| Online Access: | http://hdl.handle.net/20.500.11937/63294 |
| _version_ | 1848761047671898112 |
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| author | Kwong, S. Ramsay, Joshua Jensen, S. Firth, N. |
| author_facet | Kwong, S. Ramsay, Joshua Jensen, S. Firth, N. |
| author_sort | Kwong, S. |
| building | Curtin Institutional Repository |
| collection | Online Access |
| description | © 2017 Kwong, Ramsay, Jensen and Firth. The currently widespread and increasing prevalence of resistant bacterial pathogens is a significant medical problem. In clinical strains of staphylococci, the genetic determinants that confer resistance to antimicrobial agents are often located on mobile elements, such as plasmids. Many of these resistance plasmids are capable of horizontal transmission to other bacteria in their surroundings, allowing extraordinarily rapid adaptation of bacterial populations. Once the resistance plasmids have been spread, they are often perpetually maintained in the new host, even in the absence of selective pressure. Plasmid persistence is accomplished by plasmid-encoded genetic systems that ensure efficient replication and segregational stability during cell division. Staphylococcal plasmids utilize proteins of evolutionarily diverse families to initiate replication from the plasmid origin of replication. Several distinctive plasmid copy number control mechanisms have been studied in detail and these appear conserved within plasmid classes. The initiators utilize various strategies and serve a multifunctional role in (i) recognition and processing of the cognate replication origin to an initiation active form and (ii) recruitment of host-encoded replication proteins that facilitate replisome assembly. Understanding the detailed molecular mechanisms that underpin plasmid replication may lead to novel approaches that could be used to reverse or slow the development of resistance. |
| first_indexed | 2025-11-14T10:25:28Z |
| format | Journal Article |
| id | curtin-20.500.11937-63294 |
| institution | Curtin University Malaysia |
| institution_category | Local University |
| last_indexed | 2025-11-14T10:25:28Z |
| publishDate | 2017 |
| publisher | Frontiers Research Foundation |
| recordtype | eprints |
| repository_type | Digital Repository |
| spelling | curtin-20.500.11937-632942018-03-28T06:11:40Z Replication of staphylococcal resistance plasmids Kwong, S. Ramsay, Joshua Jensen, S. Firth, N. © 2017 Kwong, Ramsay, Jensen and Firth. The currently widespread and increasing prevalence of resistant bacterial pathogens is a significant medical problem. In clinical strains of staphylococci, the genetic determinants that confer resistance to antimicrobial agents are often located on mobile elements, such as plasmids. Many of these resistance plasmids are capable of horizontal transmission to other bacteria in their surroundings, allowing extraordinarily rapid adaptation of bacterial populations. Once the resistance plasmids have been spread, they are often perpetually maintained in the new host, even in the absence of selective pressure. Plasmid persistence is accomplished by plasmid-encoded genetic systems that ensure efficient replication and segregational stability during cell division. Staphylococcal plasmids utilize proteins of evolutionarily diverse families to initiate replication from the plasmid origin of replication. Several distinctive plasmid copy number control mechanisms have been studied in detail and these appear conserved within plasmid classes. The initiators utilize various strategies and serve a multifunctional role in (i) recognition and processing of the cognate replication origin to an initiation active form and (ii) recruitment of host-encoded replication proteins that facilitate replisome assembly. Understanding the detailed molecular mechanisms that underpin plasmid replication may lead to novel approaches that could be used to reverse or slow the development of resistance. 2017 Journal Article http://hdl.handle.net/20.500.11937/63294 10.3389/fmicb.2017.02279 http://creativecommons.org/licenses/by/4.0/ Frontiers Research Foundation fulltext |
| spellingShingle | Kwong, S. Ramsay, Joshua Jensen, S. Firth, N. Replication of staphylococcal resistance plasmids |
| title | Replication of staphylococcal resistance plasmids |
| title_full | Replication of staphylococcal resistance plasmids |
| title_fullStr | Replication of staphylococcal resistance plasmids |
| title_full_unstemmed | Replication of staphylococcal resistance plasmids |
| title_short | Replication of staphylococcal resistance plasmids |
| title_sort | replication of staphylococcal resistance plasmids |
| url | http://hdl.handle.net/20.500.11937/63294 |