Structural alterations of the social brain: A comparison between schizophrenia and autism
© 2014 Radeloff et al. Autism spectrum disorder and schizophrenia share a substantial number of etiologic and phenotypic characteristics. Still, no direct comparison of both disorders has been performed to identify differences and commonalities in bra in structure. In this voxel based morphometry st...
| Main Authors: | , , , , , , , , , |
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| Format: | Journal Article |
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Public Library of Science
2014
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| Online Access: | http://hdl.handle.net/20.500.11937/63278 |
| _version_ | 1848761043358056448 |
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| author | Radeloff, D. Ciaramidaro, A. Siniatchkin, M. Hainz, D. Schlitt, S. Weber, B. Poustka, F. Bolte, Sven Walter, H. Freitag, C. |
| author_facet | Radeloff, D. Ciaramidaro, A. Siniatchkin, M. Hainz, D. Schlitt, S. Weber, B. Poustka, F. Bolte, Sven Walter, H. Freitag, C. |
| author_sort | Radeloff, D. |
| building | Curtin Institutional Repository |
| collection | Online Access |
| description | © 2014 Radeloff et al. Autism spectrum disorder and schizophrenia share a substantial number of etiologic and phenotypic characteristics. Still, no direct comparison of both disorders has been performed to identify differences and commonalities in bra in structure. In this voxel based morphometry study, 34 patients with autism spectrum disorder, 21 patients with schizophrenia and 26 typically developed control subjects were included to identify global and regional brain volume alterations. No global gray matter or white matter differences were found between groups. In regional data, patients with autism spectrum disorder compared to typically developed control subjects showed smaller gray matter volume in the amygdala, insula, and anterior medial prefrontal cortex. Compared to patients with schizophrenia, patients with autism spectrum disorder displayed smaller gray matter volume in the left insula. Disorder specific positive correlations were found between mentalizing ability and left amygdala volume in autism spectrum disorder, and hallucinatory behavior and insula volume in schizophrenia. Results suggest the involvement of social brain areas in both disorders. Further studies are needed to replicate these findings and to quantify the amount of distinct and overlapping neural correlates in autism spectrum disorder and schizophrenia. |
| first_indexed | 2025-11-14T10:25:24Z |
| format | Journal Article |
| id | curtin-20.500.11937-63278 |
| institution | Curtin University Malaysia |
| institution_category | Local University |
| last_indexed | 2025-11-14T10:25:24Z |
| publishDate | 2014 |
| publisher | Public Library of Science |
| recordtype | eprints |
| repository_type | Digital Repository |
| spelling | curtin-20.500.11937-632782018-02-06T06:24:17Z Structural alterations of the social brain: A comparison between schizophrenia and autism Radeloff, D. Ciaramidaro, A. Siniatchkin, M. Hainz, D. Schlitt, S. Weber, B. Poustka, F. Bolte, Sven Walter, H. Freitag, C. © 2014 Radeloff et al. Autism spectrum disorder and schizophrenia share a substantial number of etiologic and phenotypic characteristics. Still, no direct comparison of both disorders has been performed to identify differences and commonalities in bra in structure. In this voxel based morphometry study, 34 patients with autism spectrum disorder, 21 patients with schizophrenia and 26 typically developed control subjects were included to identify global and regional brain volume alterations. No global gray matter or white matter differences were found between groups. In regional data, patients with autism spectrum disorder compared to typically developed control subjects showed smaller gray matter volume in the amygdala, insula, and anterior medial prefrontal cortex. Compared to patients with schizophrenia, patients with autism spectrum disorder displayed smaller gray matter volume in the left insula. Disorder specific positive correlations were found between mentalizing ability and left amygdala volume in autism spectrum disorder, and hallucinatory behavior and insula volume in schizophrenia. Results suggest the involvement of social brain areas in both disorders. Further studies are needed to replicate these findings and to quantify the amount of distinct and overlapping neural correlates in autism spectrum disorder and schizophrenia. 2014 Journal Article http://hdl.handle.net/20.500.11937/63278 10.1371/journal.pone.0106539 Public Library of Science unknown |
| spellingShingle | Radeloff, D. Ciaramidaro, A. Siniatchkin, M. Hainz, D. Schlitt, S. Weber, B. Poustka, F. Bolte, Sven Walter, H. Freitag, C. Structural alterations of the social brain: A comparison between schizophrenia and autism |
| title | Structural alterations of the social brain: A comparison between schizophrenia and autism |
| title_full | Structural alterations of the social brain: A comparison between schizophrenia and autism |
| title_fullStr | Structural alterations of the social brain: A comparison between schizophrenia and autism |
| title_full_unstemmed | Structural alterations of the social brain: A comparison between schizophrenia and autism |
| title_short | Structural alterations of the social brain: A comparison between schizophrenia and autism |
| title_sort | structural alterations of the social brain: a comparison between schizophrenia and autism |
| url | http://hdl.handle.net/20.500.11937/63278 |