Topical nano and microemulsions for skin delivery
© 2017 by the authors. Licensee MDPI, Basel, Switzerland. Nanosystems such as microemulsions (ME) and nanoemulsions (NE) offer considerable opportunities for targeted drug delivery to and via the skin. ME and NE are stable colloidal systems composed of oil and water, stabilised by a mixture of surfa...
| Main Authors: | , , , , , |
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| Format: | Journal Article |
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MDPIAG
2017
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| Online Access: | http://hdl.handle.net/20.500.11937/63140 |
| _version_ | 1848761005641826304 |
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| author | Nastiti, Christofori Ponto, Thellie Abd, E. Grice, J. Benson, Heather Roberts, M. |
| author_facet | Nastiti, Christofori Ponto, Thellie Abd, E. Grice, J. Benson, Heather Roberts, M. |
| author_sort | Nastiti, Christofori |
| building | Curtin Institutional Repository |
| collection | Online Access |
| description | © 2017 by the authors. Licensee MDPI, Basel, Switzerland. Nanosystems such as microemulsions (ME) and nanoemulsions (NE) offer considerable opportunities for targeted drug delivery to and via the skin. ME and NE are stable colloidal systems composed of oil and water, stabilised by a mixture of surfactants and cosurfactants, that have received particular interest as topical skin delivery systems. There is considerable scope to manipulate the formulation components and characteristics to achieve optimal bioavailability and minimal skin irritancy. This includes the incorporation of established chemical penetration enhancers to fluidize the stratum corneum lipid bilayers, thus reducing the primary skin barrier and increasing permeation. This review discusses nanosystems with utility in skin delivery and focuses on the composition and characterization of ME a nd NE for topical and transdermal delivery. The mechanism of skin delivery across the stratum corneum and via hair follicles is reviewed with particular focus on the influence of formulation. |
| first_indexed | 2025-11-14T10:24:48Z |
| format | Journal Article |
| id | curtin-20.500.11937-63140 |
| institution | Curtin University Malaysia |
| institution_category | Local University |
| last_indexed | 2025-11-14T10:24:48Z |
| publishDate | 2017 |
| publisher | MDPIAG |
| recordtype | eprints |
| repository_type | Digital Repository |
| spelling | curtin-20.500.11937-631402021-01-13T03:09:38Z Topical nano and microemulsions for skin delivery Nastiti, Christofori Ponto, Thellie Abd, E. Grice, J. Benson, Heather Roberts, M. © 2017 by the authors. Licensee MDPI, Basel, Switzerland. Nanosystems such as microemulsions (ME) and nanoemulsions (NE) offer considerable opportunities for targeted drug delivery to and via the skin. ME and NE are stable colloidal systems composed of oil and water, stabilised by a mixture of surfactants and cosurfactants, that have received particular interest as topical skin delivery systems. There is considerable scope to manipulate the formulation components and characteristics to achieve optimal bioavailability and minimal skin irritancy. This includes the incorporation of established chemical penetration enhancers to fluidize the stratum corneum lipid bilayers, thus reducing the primary skin barrier and increasing permeation. This review discusses nanosystems with utility in skin delivery and focuses on the composition and characterization of ME a nd NE for topical and transdermal delivery. The mechanism of skin delivery across the stratum corneum and via hair follicles is reviewed with particular focus on the influence of formulation. 2017 Journal Article http://hdl.handle.net/20.500.11937/63140 10.3390/pharmaceutics9040037 http://creativecommons.org/licenses/by/4.0/ MDPIAG fulltext |
| spellingShingle | Nastiti, Christofori Ponto, Thellie Abd, E. Grice, J. Benson, Heather Roberts, M. Topical nano and microemulsions for skin delivery |
| title | Topical nano and microemulsions for skin delivery |
| title_full | Topical nano and microemulsions for skin delivery |
| title_fullStr | Topical nano and microemulsions for skin delivery |
| title_full_unstemmed | Topical nano and microemulsions for skin delivery |
| title_short | Topical nano and microemulsions for skin delivery |
| title_sort | topical nano and microemulsions for skin delivery |
| url | http://hdl.handle.net/20.500.11937/63140 |