Fecal immunochemical test-based colorectal cancer screening: The gender dilemma
© 2016, © Author(s) 2016. Background: Despite differences between men and women in incidence of colorectal cancer (CRC) and its precursors, screening programs consistently use the same strategy for both genders. Objective: The objective of this article is to illustrate the effects of gender-tailor...
| Main Authors: | , , , , , , , , , |
|---|---|
| Format: | Journal Article |
| Published: |
2017
|
| Online Access: | http://hdl.handle.net/20.500.11937/63098 |
| _version_ | 1848760993782431744 |
|---|---|
| author | Grobbee, E. Wieten, E. Hansen, B. Stoop, E. de Wijkerslooth, T. Lansdorp-Vogelaar, Iris Bossuyt, P. Dekker, E. Kuipers, E. Spaander, M. |
| author_facet | Grobbee, E. Wieten, E. Hansen, B. Stoop, E. de Wijkerslooth, T. Lansdorp-Vogelaar, Iris Bossuyt, P. Dekker, E. Kuipers, E. Spaander, M. |
| author_sort | Grobbee, E. |
| building | Curtin Institutional Repository |
| collection | Online Access |
| description | © 2016, © Author(s) 2016. Background: Despite differences between men and women in incidence of colorectal cancer (CRC) and its precursors, screening programs consistently use the same strategy for both genders. Objective: The objective of this article is to illustrate the effects of gender-tailored screening, including the effects on miss rates of advanced neoplasia (AN). Methods: Participants (age 50–75 years) in a colonoscopy screening program were asked to complete a fecal immunochemical test (FIT) before colonoscopy. Positivity rates, sensitivity and specificity for detection of AN at multiple cut-offs were determined. Absolute numbers of detected and missed AN per 1000 screenees were calculated. Results: In total 1,256 individuals underwent FIT and colonoscopy, 51% male (median age 61 years; IQR 56–66) and 49% female (median age 60 years; IQR 55–65). At all cut-offs men had higher positivity rates than women, ranging from 3.8% to 10.8% versus 3.2% to 4.8%. Sensitivity for AN was higher in men than women; 40%–25% and 35%–22%, respectively. More AN were found and missed in absolute numbers in men at all cut-offs. Conclusion: More AN were both detected and missed in men compared to women at all cut-offs. Gender-tailored cut-offs could either level sensitivity in men and women (i.e., lower cut-off in women) or level the amount of missed lesions (i.e., lower cut-off in men). |
| first_indexed | 2025-11-14T10:24:36Z |
| format | Journal Article |
| id | curtin-20.500.11937-63098 |
| institution | Curtin University Malaysia |
| institution_category | Local University |
| last_indexed | 2025-11-14T10:24:36Z |
| publishDate | 2017 |
| recordtype | eprints |
| repository_type | Digital Repository |
| spelling | curtin-20.500.11937-630982018-02-06T06:23:10Z Fecal immunochemical test-based colorectal cancer screening: The gender dilemma Grobbee, E. Wieten, E. Hansen, B. Stoop, E. de Wijkerslooth, T. Lansdorp-Vogelaar, Iris Bossuyt, P. Dekker, E. Kuipers, E. Spaander, M. © 2016, © Author(s) 2016. Background: Despite differences between men and women in incidence of colorectal cancer (CRC) and its precursors, screening programs consistently use the same strategy for both genders. Objective: The objective of this article is to illustrate the effects of gender-tailored screening, including the effects on miss rates of advanced neoplasia (AN). Methods: Participants (age 50–75 years) in a colonoscopy screening program were asked to complete a fecal immunochemical test (FIT) before colonoscopy. Positivity rates, sensitivity and specificity for detection of AN at multiple cut-offs were determined. Absolute numbers of detected and missed AN per 1000 screenees were calculated. Results: In total 1,256 individuals underwent FIT and colonoscopy, 51% male (median age 61 years; IQR 56–66) and 49% female (median age 60 years; IQR 55–65). At all cut-offs men had higher positivity rates than women, ranging from 3.8% to 10.8% versus 3.2% to 4.8%. Sensitivity for AN was higher in men than women; 40%–25% and 35%–22%, respectively. More AN were found and missed in absolute numbers in men at all cut-offs. Conclusion: More AN were both detected and missed in men compared to women at all cut-offs. Gender-tailored cut-offs could either level sensitivity in men and women (i.e., lower cut-off in women) or level the amount of missed lesions (i.e., lower cut-off in men). 2017 Journal Article http://hdl.handle.net/20.500.11937/63098 10.1177/2050640616659998 unknown |
| spellingShingle | Grobbee, E. Wieten, E. Hansen, B. Stoop, E. de Wijkerslooth, T. Lansdorp-Vogelaar, Iris Bossuyt, P. Dekker, E. Kuipers, E. Spaander, M. Fecal immunochemical test-based colorectal cancer screening: The gender dilemma |
| title | Fecal immunochemical test-based colorectal cancer screening: The gender dilemma |
| title_full | Fecal immunochemical test-based colorectal cancer screening: The gender dilemma |
| title_fullStr | Fecal immunochemical test-based colorectal cancer screening: The gender dilemma |
| title_full_unstemmed | Fecal immunochemical test-based colorectal cancer screening: The gender dilemma |
| title_short | Fecal immunochemical test-based colorectal cancer screening: The gender dilemma |
| title_sort | fecal immunochemical test-based colorectal cancer screening: the gender dilemma |
| url | http://hdl.handle.net/20.500.11937/63098 |