Transdifferentiation of myoblasts into osteoblasts - possible use for bone therapy
© 2017 Royal Pharmaceutical Society. Objectives: Transdifferentiation is defined as the conversion of one cell type to another and is an ever-expanding field with a growing number of cells found to be capable of such a process. To date, the fact remains that there are limited treatment options for f...
| Main Authors: | , , , |
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| Format: | Journal Article |
| Published: |
John Wiley & Sons Ltd.
2017
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| Online Access: | http://hdl.handle.net/20.500.11937/63011 |
| _version_ | 1848760970283843584 |
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| author | Lin, Daphne Carnagarin, Revathy Dharmarajan, Arunasalam Dass, Crispin |
| author_facet | Lin, Daphne Carnagarin, Revathy Dharmarajan, Arunasalam Dass, Crispin |
| author_sort | Lin, Daphne |
| building | Curtin Institutional Repository |
| collection | Online Access |
| description | © 2017 Royal Pharmaceutical Society. Objectives: Transdifferentiation is defined as the conversion of one cell type to another and is an ever-expanding field with a growing number of cells found to be capable of such a process. To date, the fact remains that there are limited treatment options for fracture healing, osteoporosis and bone repair post-destruction by bone tumours. Hence, this review focuses on the transdifferentiation of myoblast to osteoblast as a means to further understand the transdifferentiation process and to investigate a potential therapeutic option if successful. Key findings: The potent osteoinductive effects of the bone morphogenetic protein-2 are largely implicated in the transdifferentiation of myoblast to osteoblast. Bone morphogenetic protein-2-induced activation of the Smad1 protein ultimately results in JunB synthesis, the first transcriptional step in myoblast dedifferentiation. The upregulation of the activating protein-1 binding activity triggers the transcription of the runt-related transcription factor 2 gene, a transcription factor that plays a major role in osteoblast differentiation. Summary: This potential transdifferentiation treatment may be utilised for dental implants, fracture healing, osteoporosis and bone repair post-destruction by bone tumours. |
| first_indexed | 2025-11-14T10:24:14Z |
| format | Journal Article |
| id | curtin-20.500.11937-63011 |
| institution | Curtin University Malaysia |
| institution_category | Local University |
| last_indexed | 2025-11-14T10:24:14Z |
| publishDate | 2017 |
| publisher | John Wiley & Sons Ltd. |
| recordtype | eprints |
| repository_type | Digital Repository |
| spelling | curtin-20.500.11937-630112018-06-08T03:01:45Z Transdifferentiation of myoblasts into osteoblasts - possible use for bone therapy Lin, Daphne Carnagarin, Revathy Dharmarajan, Arunasalam Dass, Crispin © 2017 Royal Pharmaceutical Society. Objectives: Transdifferentiation is defined as the conversion of one cell type to another and is an ever-expanding field with a growing number of cells found to be capable of such a process. To date, the fact remains that there are limited treatment options for fracture healing, osteoporosis and bone repair post-destruction by bone tumours. Hence, this review focuses on the transdifferentiation of myoblast to osteoblast as a means to further understand the transdifferentiation process and to investigate a potential therapeutic option if successful. Key findings: The potent osteoinductive effects of the bone morphogenetic protein-2 are largely implicated in the transdifferentiation of myoblast to osteoblast. Bone morphogenetic protein-2-induced activation of the Smad1 protein ultimately results in JunB synthesis, the first transcriptional step in myoblast dedifferentiation. The upregulation of the activating protein-1 binding activity triggers the transcription of the runt-related transcription factor 2 gene, a transcription factor that plays a major role in osteoblast differentiation. Summary: This potential transdifferentiation treatment may be utilised for dental implants, fracture healing, osteoporosis and bone repair post-destruction by bone tumours. 2017 Journal Article http://hdl.handle.net/20.500.11937/63011 10.1111/jphp.12790 John Wiley & Sons Ltd. unknown |
| spellingShingle | Lin, Daphne Carnagarin, Revathy Dharmarajan, Arunasalam Dass, Crispin Transdifferentiation of myoblasts into osteoblasts - possible use for bone therapy |
| title | Transdifferentiation of myoblasts into osteoblasts - possible use for bone therapy |
| title_full | Transdifferentiation of myoblasts into osteoblasts - possible use for bone therapy |
| title_fullStr | Transdifferentiation of myoblasts into osteoblasts - possible use for bone therapy |
| title_full_unstemmed | Transdifferentiation of myoblasts into osteoblasts - possible use for bone therapy |
| title_short | Transdifferentiation of myoblasts into osteoblasts - possible use for bone therapy |
| title_sort | transdifferentiation of myoblasts into osteoblasts - possible use for bone therapy |
| url | http://hdl.handle.net/20.500.11937/63011 |