SREBP-1c as a molecular bridge between lipogenesis and cell cycle progression of clear cell renal carcinoma
Sterol regulatory element binding protein 1c (SREBP-1c) promotes lipogenesis and tumor growth in various cancers. It is well known that clear cell renal cell carcinoma (ccRCC), a major subtype of the kidney cancers, exhibits elevated lipid accumulation. However, it has not been fully understood how...
| Main Authors: | , , |
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| Format: | Journal Article |
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2017
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| Online Access: | http://hdl.handle.net/20.500.11937/62753 |
| _version_ | 1848760909155008512 |
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| author | Sethi, G. Shanmugam, M. Kumar, Alan Prem |
| author_facet | Sethi, G. Shanmugam, M. Kumar, Alan Prem |
| author_sort | Sethi, G. |
| building | Curtin Institutional Repository |
| collection | Online Access |
| description | Sterol regulatory element binding protein 1c (SREBP-1c) promotes lipogenesis and tumor growth in various cancers. It is well known that clear cell renal cell carcinoma (ccRCC), a major subtype of the kidney cancers, exhibits elevated lipid accumulation. However, it has not been fully understood how lipid metabolism might be associated with cell cycle regulation in ccRCC. In a recent issue, Lee et al. (Molecular and Cellular Biology (2017) pii: MCB.00265-17) demonstrate that SREBP-1c is up-regulated in ccRCC by ring finger protein 20 (RNF20) down-regulation, leading to aberrant lipid storage and pituitary tumor transforming gene 1 (PTTG1)-dependent cell cycle progression. These findings suggest that SREBP-1c serves as a molecular bridge between lipid metabolism and cell cycle control in ccRCC tumorigenesis. |
| first_indexed | 2025-11-14T10:23:16Z |
| format | Journal Article |
| id | curtin-20.500.11937-62753 |
| institution | Curtin University Malaysia |
| institution_category | Local University |
| last_indexed | 2025-11-14T10:23:16Z |
| publishDate | 2017 |
| recordtype | eprints |
| repository_type | Digital Repository |
| spelling | curtin-20.500.11937-627532018-02-01T05:58:35Z SREBP-1c as a molecular bridge between lipogenesis and cell cycle progression of clear cell renal carcinoma Sethi, G. Shanmugam, M. Kumar, Alan Prem Sterol regulatory element binding protein 1c (SREBP-1c) promotes lipogenesis and tumor growth in various cancers. It is well known that clear cell renal cell carcinoma (ccRCC), a major subtype of the kidney cancers, exhibits elevated lipid accumulation. However, it has not been fully understood how lipid metabolism might be associated with cell cycle regulation in ccRCC. In a recent issue, Lee et al. (Molecular and Cellular Biology (2017) pii: MCB.00265-17) demonstrate that SREBP-1c is up-regulated in ccRCC by ring finger protein 20 (RNF20) down-regulation, leading to aberrant lipid storage and pituitary tumor transforming gene 1 (PTTG1)-dependent cell cycle progression. These findings suggest that SREBP-1c serves as a molecular bridge between lipid metabolism and cell cycle control in ccRCC tumorigenesis. 2017 Journal Article http://hdl.handle.net/20.500.11937/62753 10.1042/BSR20171270 unknown |
| spellingShingle | Sethi, G. Shanmugam, M. Kumar, Alan Prem SREBP-1c as a molecular bridge between lipogenesis and cell cycle progression of clear cell renal carcinoma |
| title | SREBP-1c as a molecular bridge between lipogenesis and cell cycle progression of clear cell renal carcinoma |
| title_full | SREBP-1c as a molecular bridge between lipogenesis and cell cycle progression of clear cell renal carcinoma |
| title_fullStr | SREBP-1c as a molecular bridge between lipogenesis and cell cycle progression of clear cell renal carcinoma |
| title_full_unstemmed | SREBP-1c as a molecular bridge between lipogenesis and cell cycle progression of clear cell renal carcinoma |
| title_short | SREBP-1c as a molecular bridge between lipogenesis and cell cycle progression of clear cell renal carcinoma |
| title_sort | srebp-1c as a molecular bridge between lipogenesis and cell cycle progression of clear cell renal carcinoma |
| url | http://hdl.handle.net/20.500.11937/62753 |