Oligomeric and fibrillar amyloid beta 42 induce platelet aggregation partially through GPVI
© 2017 Taylor & Francis The effects of the Alzheimer’s disease (AD)-associated Amyloid-ß (Aß) peptides on platelet aggregation have been previously assessed, but most of these studies focused on Aß40 species. It also remains to be determined which distinct forms of Aß peptides exert differenti...
| Main Authors: | , , , , , , , |
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| Format: | Journal Article |
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Informa Healthcare
2017
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| Online Access: | http://hdl.handle.net/20.500.11937/62420 |
| _version_ | 1848760847685386240 |
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| author | Elaskalani, O. Khan, I. Morici, M. Matthysen, C. Sabale, M. Martins, R. Verdile, G. Metharom, Pat |
| author_facet | Elaskalani, O. Khan, I. Morici, M. Matthysen, C. Sabale, M. Martins, R. Verdile, G. Metharom, Pat |
| author_sort | Elaskalani, O. |
| building | Curtin Institutional Repository |
| collection | Online Access |
| description | © 2017 Taylor & Francis The effects of the Alzheimer’s disease (AD)-associated Amyloid-ß (Aß) peptides on platelet aggregation have been previously assessed, but most of these studies focused on Aß40 species. It also remains to be determined which distinct forms of Aß peptides exert differential effects on platelets. In AD, oligomeric Aß42 species is widely thought to be a major contributor to the disease pathogenesis. We, therefore, examine the ability of oligomeric and fibrillary Aß42 to affect platelet aggregation. We show that both forms of Aß42 induced significant platelet aggregation and that it is a novel ligand for the platelet receptor GPVI. Furthermore, a novel binding peptide that reduces the formation of soluble Aß42 oligomers was effective at preventing Aß42-dependent platelet aggregation. These results support a role for Aß42 oligomers in platelet hyperactivity. |
| first_indexed | 2025-11-14T10:22:17Z |
| format | Journal Article |
| id | curtin-20.500.11937-62420 |
| institution | Curtin University Malaysia |
| institution_category | Local University |
| last_indexed | 2025-11-14T10:22:17Z |
| publishDate | 2017 |
| publisher | Informa Healthcare |
| recordtype | eprints |
| repository_type | Digital Repository |
| spelling | curtin-20.500.11937-624202018-02-01T05:58:13Z Oligomeric and fibrillar amyloid beta 42 induce platelet aggregation partially through GPVI Elaskalani, O. Khan, I. Morici, M. Matthysen, C. Sabale, M. Martins, R. Verdile, G. Metharom, Pat © 2017 Taylor & Francis The effects of the Alzheimer’s disease (AD)-associated Amyloid-ß (Aß) peptides on platelet aggregation have been previously assessed, but most of these studies focused on Aß40 species. It also remains to be determined which distinct forms of Aß peptides exert differential effects on platelets. In AD, oligomeric Aß42 species is widely thought to be a major contributor to the disease pathogenesis. We, therefore, examine the ability of oligomeric and fibrillary Aß42 to affect platelet aggregation. We show that both forms of Aß42 induced significant platelet aggregation and that it is a novel ligand for the platelet receptor GPVI. Furthermore, a novel binding peptide that reduces the formation of soluble Aß42 oligomers was effective at preventing Aß42-dependent platelet aggregation. These results support a role for Aß42 oligomers in platelet hyperactivity. 2017 Journal Article http://hdl.handle.net/20.500.11937/62420 10.1080/09537104.2017.1401057 Informa Healthcare restricted |
| spellingShingle | Elaskalani, O. Khan, I. Morici, M. Matthysen, C. Sabale, M. Martins, R. Verdile, G. Metharom, Pat Oligomeric and fibrillar amyloid beta 42 induce platelet aggregation partially through GPVI |
| title | Oligomeric and fibrillar amyloid beta 42 induce platelet aggregation partially through GPVI |
| title_full | Oligomeric and fibrillar amyloid beta 42 induce platelet aggregation partially through GPVI |
| title_fullStr | Oligomeric and fibrillar amyloid beta 42 induce platelet aggregation partially through GPVI |
| title_full_unstemmed | Oligomeric and fibrillar amyloid beta 42 induce platelet aggregation partially through GPVI |
| title_short | Oligomeric and fibrillar amyloid beta 42 induce platelet aggregation partially through GPVI |
| title_sort | oligomeric and fibrillar amyloid beta 42 induce platelet aggregation partially through gpvi |
| url | http://hdl.handle.net/20.500.11937/62420 |