Prolonged L-alanine exposure induces changes in metabolism, Ca2+ handling and desensitization of insulin secretion in clonal pancreatic ß-cells

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Prolonged L-alanine exposure induces changes in metabolism, Ca2+ handling and desensitization of insulin secretion in clonal pancreatic ß-cells

Acute insulin-releasing actions of amino acids have been studied in detail, but comparatively little is known about the ß-cell effects of long-term exposure to amino acids. The present study examined the effects of prolonged exposure of ß-cells to the metabolizable amino acid L-alanine. Basal insuli...

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Bibliographic Details
Main Authors:	McClenaghan, N., Scullion, S., Mion, B., Hewage, C., Malthouse, J., Flatt, P., Newsholme, Philip, Brennan, L.
Format:	Journal Article
Published:	Portland Press 2009
Online Access:	http://hdl.handle.net/20.500.11937/6238

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