Enhanced transdermal peptide delivery and stability by lipid conjugation: Epidermal permeation, stereoselectivity and mechanistic insights

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Enhanced transdermal peptide delivery and stability by lipid conjugation: Epidermal permeation, stereoselectivity and mechanistic insights

Purpose: Efficient delivery of therapeutic peptides to the skin will facilitate better outcomes in dermatology. The tetrapeptide AAPV, an elastase inhibitor with potential utility in the management of psoriasis was coupled to short chain lipoamino acids (Laa: C6-C10) to enhance the peptide permeatio...

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Bibliographic Details
Main Authors:	Namjoshi, S., Toth, I., Blanchfield, J., Trotter, N., Mancera, Ricardo, Benson, Heather
Format:	Journal Article
Published:	AAPS 2014
Online Access:	http://hdl.handle.net/20.500.11937/62376

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