Delivery of expression constructs of secreted frizzled-related protein 4 and its domains by chitosan–dextran sulfate nanoparticles enhances their expression and anti-cancer effects

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Delivery of expression constructs of secreted frizzled-related protein 4 and its domains by chitosan–dextran sulfate nanoparticles enhances their expression and anti-cancer effects

In malignant mesothelioma (MM) cells, secreted frizzled-related protein 4 (SFRP4) expression is downregulated by promoter methylation. In this study, we evaluated the effect of encapsulated chitosan–dextran (CS–DS) nanoparticle formulations of SFRP4 and its cysteine-rich domain (CRD) and netrin-like...

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Bibliographic Details
Main Authors:	Perumal, Vanathi, Arfuso, Frank, Chen, Yan, Fox, Simon, Dharmarajan, Arunasalam
Format:	Journal Article
Published:	2017
Online Access:	http://hdl.handle.net/20.500.11937/62223

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