The association between Staphylococcus aureus and subsequent bronchiectasis in children with cystic fibrosis
© 2017 European Cystic Fibrosis Society. Background: Staphylococcus aureus (S. aureus) may be related to more rapid progression of cystic fibrosis (CF) lung disease. Methods: In the AREST CF cohort study, children diagnosed with CF undergo annual bronchoscopies with bronchoalveolar lavage and ultra-...
| Main Authors: | , , , , , , , , |
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| Format: | Journal Article |
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Elsevier
2018
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| Online Access: | http://hdl.handle.net/20.500.11937/62077 |
| _version_ | 1848760783689744384 |
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| author | Caudri, D. Turkovic, L. Ng, J. de Klerk, N. Rosenow, T. Hall, Graham Ranganathan, S. Sly, P. Stick, S. |
| author_facet | Caudri, D. Turkovic, L. Ng, J. de Klerk, N. Rosenow, T. Hall, Graham Ranganathan, S. Sly, P. Stick, S. |
| author_sort | Caudri, D. |
| building | Curtin Institutional Repository |
| collection | Online Access |
| description | © 2017 European Cystic Fibrosis Society. Background: Staphylococcus aureus (S. aureus) may be related to more rapid progression of cystic fibrosis (CF) lung disease. Methods: In the AREST CF cohort study, children diagnosed with CF undergo annual bronchoscopies with bronchoalveolar lavage and ultra-low-dose, chest computed tomography (CT) up to 6-years-old. Spirometry was assessed 3-monthly from the age of 4. years. Associations between de novo S. aureus acquisition before school age and CT and lung function at ages 5-7. years were investigated. Models were adjusted for multiple markers of disease severity at baseline. Results: De novo S. aureus acquisition at 3-years-old (n/N=12/122) was associated with increased bronchiectasis score at age 5-6years. This association decreased but remained significant after adjustment for confounders. S. aureus at 3 was associated with significantly reduced FEF 25-75 at age 5-7years, but not with FEV 1 -%-predicted. Conclusion: De novo S. aureus acquisition at age 3 is associated with later bronchiectasis and FEF 25-75 in children with CF. |
| first_indexed | 2025-11-14T10:21:16Z |
| format | Journal Article |
| id | curtin-20.500.11937-62077 |
| institution | Curtin University Malaysia |
| institution_category | Local University |
| last_indexed | 2025-11-14T10:21:16Z |
| publishDate | 2018 |
| publisher | Elsevier |
| recordtype | eprints |
| repository_type | Digital Repository |
| spelling | curtin-20.500.11937-620772019-07-12T06:03:33Z The association between Staphylococcus aureus and subsequent bronchiectasis in children with cystic fibrosis Caudri, D. Turkovic, L. Ng, J. de Klerk, N. Rosenow, T. Hall, Graham Ranganathan, S. Sly, P. Stick, S. © 2017 European Cystic Fibrosis Society. Background: Staphylococcus aureus (S. aureus) may be related to more rapid progression of cystic fibrosis (CF) lung disease. Methods: In the AREST CF cohort study, children diagnosed with CF undergo annual bronchoscopies with bronchoalveolar lavage and ultra-low-dose, chest computed tomography (CT) up to 6-years-old. Spirometry was assessed 3-monthly from the age of 4. years. Associations between de novo S. aureus acquisition before school age and CT and lung function at ages 5-7. years were investigated. Models were adjusted for multiple markers of disease severity at baseline. Results: De novo S. aureus acquisition at 3-years-old (n/N=12/122) was associated with increased bronchiectasis score at age 5-6years. This association decreased but remained significant after adjustment for confounders. S. aureus at 3 was associated with significantly reduced FEF 25-75 at age 5-7years, but not with FEV 1 -%-predicted. Conclusion: De novo S. aureus acquisition at age 3 is associated with later bronchiectasis and FEF 25-75 in children with CF. 2018 Journal Article http://hdl.handle.net/20.500.11937/62077 10.1016/j.jcf.2017.12.002 Elsevier restricted |
| spellingShingle | Caudri, D. Turkovic, L. Ng, J. de Klerk, N. Rosenow, T. Hall, Graham Ranganathan, S. Sly, P. Stick, S. The association between Staphylococcus aureus and subsequent bronchiectasis in children with cystic fibrosis |
| title | The association between Staphylococcus aureus and subsequent bronchiectasis in children with cystic fibrosis |
| title_full | The association between Staphylococcus aureus and subsequent bronchiectasis in children with cystic fibrosis |
| title_fullStr | The association between Staphylococcus aureus and subsequent bronchiectasis in children with cystic fibrosis |
| title_full_unstemmed | The association between Staphylococcus aureus and subsequent bronchiectasis in children with cystic fibrosis |
| title_short | The association between Staphylococcus aureus and subsequent bronchiectasis in children with cystic fibrosis |
| title_sort | association between staphylococcus aureus and subsequent bronchiectasis in children with cystic fibrosis |
| url | http://hdl.handle.net/20.500.11937/62077 |