Population-based detection of lynch syndrome in young colorectal cancer patients using microsatellite instability as the initial test

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Population-based detection of lynch syndrome in young colorectal cancer patients using microsatellite instability as the initial test

Approximately 1-2% of colorectal cancers (CRC) arise because of germline mutations in UNA mismatch repair genes, referred to as Lynch syndrome. These tumours show microsatellite instability (MSI) and loss of expression of mismatch repair proteins. Pre-symptomatic identiication of mutation carriers h...

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Bibliographic Details
Main Authors:	Sehofield, L., Watson, N., Grieu, F., Wei, Q., Zeps, Nikolajs, Harvey, J., Stewart, C., Abclo, M., Goldblatt, J., Iacopetta, B.
Format:	Journal Article
Published:	John Wiley & Sons, Inc. 2009
Online Access:	http://hdl.handle.net/20.500.11937/6157

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