The non-classical ArsR-family repressor PyeR (PA4354) modulates biofilm formation in Pseudomonas aeruginosa
PyeR (PA4354) is a novel member of the ArsR family of transcriptional regulators and modulates biofilm formation in Pseudomonas aeruginosa. Characterization of this regulator showed that it has negative autoregulatory properties and binds to a palindromic motif conserved among PyeR orthologues. Thes...
| Main Authors: | , , , , , , , , , |
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| Format: | Journal Article |
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Society for General Microbiology
2012
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| Online Access: | http://hdl.handle.net/20.500.11937/6140 |
| _version_ | 1848744991129600000 |
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| author | Mac Aogáin, M. Mooij, M. McCarthy, R. Plower, E. Wang, Y. Tian, Z. Dobson, A. Morrissey, J. Adams, C. O'Gara, Fergal |
| author_facet | Mac Aogáin, M. Mooij, M. McCarthy, R. Plower, E. Wang, Y. Tian, Z. Dobson, A. Morrissey, J. Adams, C. O'Gara, Fergal |
| author_sort | Mac Aogáin, M. |
| building | Curtin Institutional Repository |
| collection | Online Access |
| description | PyeR (PA4354) is a novel member of the ArsR family of transcriptional regulators and modulates biofilm formation in Pseudomonas aeruginosa. Characterization of this regulator showed that it has negative autoregulatory properties and binds to a palindromic motif conserved among PyeR orthologues. These characteristics are in line with classical ArsR-family regulators, as is the fact that PyeR is part of an operon structure (pyeR-pyeM-xenB). However, PyeR also exhibits some atypical features in comparison with classical members of the ArsR family, as it does not harbour metal-binding motifs and does not appear to be involved in metal perception or resistance. Hence, PyeR belongs to a subgroup of non-classical ArsR-family regulators and is the second ArsR regulator shown to be involved in biofilm formation. |
| first_indexed | 2025-11-14T06:10:15Z |
| format | Journal Article |
| id | curtin-20.500.11937-6140 |
| institution | Curtin University Malaysia |
| institution_category | Local University |
| last_indexed | 2025-11-14T06:10:15Z |
| publishDate | 2012 |
| publisher | Society for General Microbiology |
| recordtype | eprints |
| repository_type | Digital Repository |
| spelling | curtin-20.500.11937-61402023-02-22T06:24:21Z The non-classical ArsR-family repressor PyeR (PA4354) modulates biofilm formation in Pseudomonas aeruginosa Mac Aogáin, M. Mooij, M. McCarthy, R. Plower, E. Wang, Y. Tian, Z. Dobson, A. Morrissey, J. Adams, C. O'Gara, Fergal PyeR (PA4354) is a novel member of the ArsR family of transcriptional regulators and modulates biofilm formation in Pseudomonas aeruginosa. Characterization of this regulator showed that it has negative autoregulatory properties and binds to a palindromic motif conserved among PyeR orthologues. These characteristics are in line with classical ArsR-family regulators, as is the fact that PyeR is part of an operon structure (pyeR-pyeM-xenB). However, PyeR also exhibits some atypical features in comparison with classical members of the ArsR family, as it does not harbour metal-binding motifs and does not appear to be involved in metal perception or resistance. Hence, PyeR belongs to a subgroup of non-classical ArsR-family regulators and is the second ArsR regulator shown to be involved in biofilm formation. 2012 Journal Article http://hdl.handle.net/20.500.11937/6140 10.1099/mic.0.058636-0 Society for General Microbiology unknown |
| spellingShingle | Mac Aogáin, M. Mooij, M. McCarthy, R. Plower, E. Wang, Y. Tian, Z. Dobson, A. Morrissey, J. Adams, C. O'Gara, Fergal The non-classical ArsR-family repressor PyeR (PA4354) modulates biofilm formation in Pseudomonas aeruginosa |
| title | The non-classical ArsR-family repressor PyeR (PA4354) modulates biofilm formation in Pseudomonas aeruginosa |
| title_full | The non-classical ArsR-family repressor PyeR (PA4354) modulates biofilm formation in Pseudomonas aeruginosa |
| title_fullStr | The non-classical ArsR-family repressor PyeR (PA4354) modulates biofilm formation in Pseudomonas aeruginosa |
| title_full_unstemmed | The non-classical ArsR-family repressor PyeR (PA4354) modulates biofilm formation in Pseudomonas aeruginosa |
| title_short | The non-classical ArsR-family repressor PyeR (PA4354) modulates biofilm formation in Pseudomonas aeruginosa |
| title_sort | non-classical arsr-family repressor pyer (pa4354) modulates biofilm formation in pseudomonas aeruginosa |
| url | http://hdl.handle.net/20.500.11937/6140 |