The effect of hydronium ions on the structure of phospholipid membranes
This work seeks to identify the mechanisms by which hydronium ions (H 3 O + ) modulate the structure of phospholipid bilayers by studying the interactions of H 3 O + with phospholipids at the molecular level. For this, we carried out multiple microsecond-long unrestrained molecular dynamics (MD) sim...
| Main Authors: | , , , |
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| Format: | Journal Article |
| Published: |
R S C Publications
2017
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| Online Access: | http://hdl.handle.net/20.500.11937/60740 |
| Summary: | This work seeks to identify the mechanisms by which hydronium ions (H 3 O + ) modulate the structure of phospholipid bilayers by studying the interactions of H 3 O + with phospholipids at the molecular level. For this, we carried out multiple microsecond-long unrestrained molecular dynamics (MD) simulations of a POPC bilayer at different H 3 O + concentrations. The results show that H 3 O + accumulates at the membrane surface where it displaces water and forms strong and long-lived hydrogen bonds with the phosphate and carbonyl oxygens in phospholipids. This results in a concentration-dependent reduction of the area per lipid and an increase in bilayer thickness. This study provides an important molecular-level insight into the mechanism of how H 3 O + modulates the structure of biological membranes and is a critical step towards a better understanding of the effect of low pH on mammalian and bacterial membranes. |
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