Novel Key Biofilm-Forming Surface-Associated Polysaccharide and Protein Antigens of Bordetella pertussis and the Comparative Immunoprotective Potential
Whooping cough has resurged in several countries, despite high vaccine coverage, representing a significant public health concern. Biofilm formation has recently been associated with the pathogenesis of Bordetella pertussis. I showed that vaccination of mice with biofilm and two novel biofilm-upregu...
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| Format: | Thesis |
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Curtin University
2017
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| Online Access: | http://hdl.handle.net/20.500.11937/59629 |
| _version_ | 1848760540522872832 |
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| author | Dorji |
| author_facet | Dorji |
| author_sort | Dorji |
| building | Curtin Institutional Repository |
| collection | Online Access |
| description | Whooping cough has resurged in several countries, despite high vaccine coverage, representing a significant public health concern. Biofilm formation has recently been associated with the pathogenesis of Bordetella pertussis. I showed that vaccination of mice with biofilm and two novel biofilm-upregulated proteins induced Th1 immune responses and protected mice from virulent B. pertussis infection. The study identified a novel role of biofilm and its associated antigens as potential new whooping cough vaccines. |
| first_indexed | 2025-11-14T10:17:24Z |
| format | Thesis |
| id | curtin-20.500.11937-59629 |
| institution | Curtin University Malaysia |
| institution_category | Local University |
| last_indexed | 2025-11-14T10:17:24Z |
| publishDate | 2017 |
| publisher | Curtin University |
| recordtype | eprints |
| repository_type | Digital Repository |
| spelling | curtin-20.500.11937-596292018-12-04T00:51:15Z Novel Key Biofilm-Forming Surface-Associated Polysaccharide and Protein Antigens of Bordetella pertussis and the Comparative Immunoprotective Potential Dorji Whooping cough has resurged in several countries, despite high vaccine coverage, representing a significant public health concern. Biofilm formation has recently been associated with the pathogenesis of Bordetella pertussis. I showed that vaccination of mice with biofilm and two novel biofilm-upregulated proteins induced Th1 immune responses and protected mice from virulent B. pertussis infection. The study identified a novel role of biofilm and its associated antigens as potential new whooping cough vaccines. 2017 Thesis http://hdl.handle.net/20.500.11937/59629 Curtin University fulltext |
| spellingShingle | Dorji Novel Key Biofilm-Forming Surface-Associated Polysaccharide and Protein Antigens of Bordetella pertussis and the Comparative Immunoprotective Potential |
| title | Novel Key Biofilm-Forming Surface-Associated Polysaccharide and Protein Antigens of Bordetella pertussis and the Comparative Immunoprotective Potential |
| title_full | Novel Key Biofilm-Forming Surface-Associated Polysaccharide and Protein Antigens of Bordetella pertussis and the Comparative Immunoprotective Potential |
| title_fullStr | Novel Key Biofilm-Forming Surface-Associated Polysaccharide and Protein Antigens of Bordetella pertussis and the Comparative Immunoprotective Potential |
| title_full_unstemmed | Novel Key Biofilm-Forming Surface-Associated Polysaccharide and Protein Antigens of Bordetella pertussis and the Comparative Immunoprotective Potential |
| title_short | Novel Key Biofilm-Forming Surface-Associated Polysaccharide and Protein Antigens of Bordetella pertussis and the Comparative Immunoprotective Potential |
| title_sort | novel key biofilm-forming surface-associated polysaccharide and protein antigens of bordetella pertussis and the comparative immunoprotective potential |
| url | http://hdl.handle.net/20.500.11937/59629 |