The impact of the metabotropic glutamate receptor and other gene family interaction networks on autism

The impact of the metabotropic glutamate receptor and other gene family interaction networks on autism

Although multiple reports show that defective genetic networks underlie the aetiology of autism, few have translated into pharmacotherapeutic opportunities. Since drugs compete with endogenous small molecules for protein binding, many successful drugs target large gene families with multiple drug bi...

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Main Authors: Hadley, D., Wu, Z., Kao, C., Kini, A., Mohamed-Hadley, A., Thomas, K., Vazquez, L., Qiu, H., Mentch, F., Pellegrino, R., Kim, C., Connolly, J., Glessner, J., Hakonarson, H., Pinto, D., Merikangas, A., Klei, L., Vorstman, J., Thompson, A., Regan, R., Pagnamenta, A., Oliveira, B., Magalhaes, T., Gilbert, J., Duketis, E., De Jonge, M., Cuccaro, M., Correia, C., Conroy, J., Conceiça, I., Chiocchetti, A., Casey, J., Bolshakova, N., Bacchelli, E., Anney, R., Zwaigenbaum, L., Wittemeyer, K., Wallace, S., Van Engeland, H., Soorya, L., Rogé, B., Roberts, W., Poustka, F., Mouga, S., Minshew, N., McGrew, S., Lord, C., Leboyer, M., Le Couteur, A., Kolevzon, A., Jacob, S., Guter, S., Green, J., Green, A., Gillberg, C., Fernandez, B., Duque, F., Delorme, R., Dawson, G., Brennan, S., Bourgeron, T., Bolton, P., Bolte, Sven
Format: Journal Article
Published: Macmillan Publishers Limited 2014
Online Access:http://hdl.handle.net/20.500.11937/59455

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