Disease trends over time and CD4+CCR5+ T-cells expansion predict carotid atherosclerosis development in patients with systemic lupus erythematosus
Background and Aim: Patients with Systemic Lupus Erythematosus (SLE) present increased cardiovascular mortality compared to the general population. Few studies have assessed the long-term development and progression of carotid atherosclerotic plaque in SLE patients. Our aim was to investigate the as...
| Main Authors: | , , , , , , , , , , , , , |
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| Format: | Journal Article |
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Elsevier
2017
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| Online Access: | http://hdl.handle.net/20.500.11937/59448 |
| _version_ | 1848760483137454080 |
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| author | Baragetti, A. Ramirez, G. Magnoni, M. Garlaschelli, K. Grigore, L. Berteotti, M. Scotti, I. Bozzolo, E. Berti, A. Camici, P. Catapano, A. Manfredi, A. Ammirati, E. Norata, Giuseppe |
| author_facet | Baragetti, A. Ramirez, G. Magnoni, M. Garlaschelli, K. Grigore, L. Berteotti, M. Scotti, I. Bozzolo, E. Berti, A. Camici, P. Catapano, A. Manfredi, A. Ammirati, E. Norata, Giuseppe |
| author_sort | Baragetti, A. |
| building | Curtin Institutional Repository |
| collection | Online Access |
| description | Background and Aim: Patients with Systemic Lupus Erythematosus (SLE) present increased cardiovascular mortality compared to the general population. Few studies have assessed the long-term development and progression of carotid atherosclerotic plaque in SLE patients. Our aim was to investigate the association of clinical and laboratory markers of disease activity and classical cardiovascular risk factors (CVRF) with carotid atherosclerosis development in SLE patients in a prospective 5-year study. Methods and results: Clinical history and information on principal CVRFs were collected at baseline and after 5 years in 40 SLE patients (36 women, mean age 42 ± 9 years; 14.4 ± 7 years of mean disease duration) and 50 age-matched controls. Carotid Doppler ultrasonography was employed to quantify the atherosclerotic burden at baseline and at follow up. Clinimetrics were applied to assess SLE activity over time (SLEDAI). The association between basal circulating T cell subsets (including CD4 + CCR5 + ; CD4 + CXCR3 + ; CD4 + HLADR + ; CD4 + CD45RA + RO - , CD4 + CD45RO + RA - and their subsets) and atherosclerosis development was evaluated. During the 5-year follow up, 32% of SLE patients, developed carotid atherosclerosis compared to 4% of controls. Furthermore, considering SLEDAI changes over time, patients within the highest tertile were those with increased incidence of carotid atherosclerosis independently of CVRF. In addition, increased levels of CD4 + CCR5 + T cells were independently associated with the development of carotid atherosclerosis in SLE patients. Conclusion: Serial clinical evaluations over time, rather than a single point estimation of disease activity or CVRF burden, are required to define the risk of carotid atherosclerosis development in SLE patients. Specific T cell subsets are associated with long-term atherosclerotic progression and may further be of help in predicting vascular disease progression. |
| first_indexed | 2025-11-14T10:16:29Z |
| format | Journal Article |
| id | curtin-20.500.11937-59448 |
| institution | Curtin University Malaysia |
| institution_category | Local University |
| last_indexed | 2025-11-14T10:16:29Z |
| publishDate | 2017 |
| publisher | Elsevier |
| recordtype | eprints |
| repository_type | Digital Repository |
| spelling | curtin-20.500.11937-594482018-09-07T00:39:37Z Disease trends over time and CD4+CCR5+ T-cells expansion predict carotid atherosclerosis development in patients with systemic lupus erythematosus Baragetti, A. Ramirez, G. Magnoni, M. Garlaschelli, K. Grigore, L. Berteotti, M. Scotti, I. Bozzolo, E. Berti, A. Camici, P. Catapano, A. Manfredi, A. Ammirati, E. Norata, Giuseppe Background and Aim: Patients with Systemic Lupus Erythematosus (SLE) present increased cardiovascular mortality compared to the general population. Few studies have assessed the long-term development and progression of carotid atherosclerotic plaque in SLE patients. Our aim was to investigate the association of clinical and laboratory markers of disease activity and classical cardiovascular risk factors (CVRF) with carotid atherosclerosis development in SLE patients in a prospective 5-year study. Methods and results: Clinical history and information on principal CVRFs were collected at baseline and after 5 years in 40 SLE patients (36 women, mean age 42 ± 9 years; 14.4 ± 7 years of mean disease duration) and 50 age-matched controls. Carotid Doppler ultrasonography was employed to quantify the atherosclerotic burden at baseline and at follow up. Clinimetrics were applied to assess SLE activity over time (SLEDAI). The association between basal circulating T cell subsets (including CD4 + CCR5 + ; CD4 + CXCR3 + ; CD4 + HLADR + ; CD4 + CD45RA + RO - , CD4 + CD45RO + RA - and their subsets) and atherosclerosis development was evaluated. During the 5-year follow up, 32% of SLE patients, developed carotid atherosclerosis compared to 4% of controls. Furthermore, considering SLEDAI changes over time, patients within the highest tertile were those with increased incidence of carotid atherosclerosis independently of CVRF. In addition, increased levels of CD4 + CCR5 + T cells were independently associated with the development of carotid atherosclerosis in SLE patients. Conclusion: Serial clinical evaluations over time, rather than a single point estimation of disease activity or CVRF burden, are required to define the risk of carotid atherosclerosis development in SLE patients. Specific T cell subsets are associated with long-term atherosclerotic progression and may further be of help in predicting vascular disease progression. 2017 Journal Article http://hdl.handle.net/20.500.11937/59448 10.1016/j.numecd.2017.09.001 Elsevier fulltext |
| spellingShingle | Baragetti, A. Ramirez, G. Magnoni, M. Garlaschelli, K. Grigore, L. Berteotti, M. Scotti, I. Bozzolo, E. Berti, A. Camici, P. Catapano, A. Manfredi, A. Ammirati, E. Norata, Giuseppe Disease trends over time and CD4+CCR5+ T-cells expansion predict carotid atherosclerosis development in patients with systemic lupus erythematosus |
| title | Disease trends over time and CD4+CCR5+ T-cells expansion predict carotid atherosclerosis development in patients with systemic lupus erythematosus |
| title_full | Disease trends over time and CD4+CCR5+ T-cells expansion predict carotid atherosclerosis development in patients with systemic lupus erythematosus |
| title_fullStr | Disease trends over time and CD4+CCR5+ T-cells expansion predict carotid atherosclerosis development in patients with systemic lupus erythematosus |
| title_full_unstemmed | Disease trends over time and CD4+CCR5+ T-cells expansion predict carotid atherosclerosis development in patients with systemic lupus erythematosus |
| title_short | Disease trends over time and CD4+CCR5+ T-cells expansion predict carotid atherosclerosis development in patients with systemic lupus erythematosus |
| title_sort | disease trends over time and cd4+ccr5+ t-cells expansion predict carotid atherosclerosis development in patients with systemic lupus erythematosus |
| url | http://hdl.handle.net/20.500.11937/59448 |