Ion-Transfer Voltammetric Determination of the B-Blocker Propranolol in a Physiological Matrix at Silicon Membrane-Based Liquid/Liquid Microinterface Arrays
In this work, the ion-transfer voltammetric detection ofthe protonated -blocker propranolol in artificial saliva ispresented. Cyclic voltammetry, differential pulse voltammetry,and differential pulse stripping voltammetry (DPSV)were employed in the detection of the cationic drug basedon ion-transfer...
| Main Authors: | , |
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| Format: | Journal Article |
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American Chemical Society
2009
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| Online Access: | http://hdl.handle.net/20.500.11937/5935 |
| _version_ | 1848744934972063744 |
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| author | Collins, C. Arrigan, Damien |
| author_facet | Collins, C. Arrigan, Damien |
| author_sort | Collins, C. |
| building | Curtin Institutional Repository |
| collection | Online Access |
| description | In this work, the ion-transfer voltammetric detection ofthe protonated -blocker propranolol in artificial saliva ispresented. Cyclic voltammetry, differential pulse voltammetry,and differential pulse stripping voltammetry (DPSV)were employed in the detection of the cationic drug basedon ion-transfer voltammetry across arrays of microinterfacesbetween artificial saliva and an organogel phase. Itwas found that the artificial saliva matrix decreased theavailable potential window for ion-transfer voltammetryat this liquid|liquid interface but transfer of protonatedpropranolol was still achieved. The DPSV method employeda preconditioning step as well as a preconcentrationstep followed by analytical signal generation basedon the back-transfer of the drug across the array ofmicrointerfaces. The DPSV peak current response waslinear with drug concentration in the artificial saliva matrixover the concentration range of 0.05-1 µM (ip ) -8.13(nA µM-1)(concentration) + 0.07 (nA), R ) 0.9929,n ) 7), and the calculated detection limit (3sb) was0.02 µM. These results demonstrate that DPSV atarrays of liquid|liquid microinterfaces is a viable analyticalapproach for pharmaceutical determinations inbiomimetic matrixes. |
| first_indexed | 2025-11-14T06:09:22Z |
| format | Journal Article |
| id | curtin-20.500.11937-5935 |
| institution | Curtin University Malaysia |
| institution_category | Local University |
| last_indexed | 2025-11-14T06:09:22Z |
| publishDate | 2009 |
| publisher | American Chemical Society |
| recordtype | eprints |
| repository_type | Digital Repository |
| spelling | curtin-20.500.11937-59352017-02-28T01:30:24Z Ion-Transfer Voltammetric Determination of the B-Blocker Propranolol in a Physiological Matrix at Silicon Membrane-Based Liquid/Liquid Microinterface Arrays Collins, C. Arrigan, Damien In this work, the ion-transfer voltammetric detection ofthe protonated -blocker propranolol in artificial saliva ispresented. Cyclic voltammetry, differential pulse voltammetry,and differential pulse stripping voltammetry (DPSV)were employed in the detection of the cationic drug basedon ion-transfer voltammetry across arrays of microinterfacesbetween artificial saliva and an organogel phase. Itwas found that the artificial saliva matrix decreased theavailable potential window for ion-transfer voltammetryat this liquid|liquid interface but transfer of protonatedpropranolol was still achieved. The DPSV method employeda preconditioning step as well as a preconcentrationstep followed by analytical signal generation basedon the back-transfer of the drug across the array ofmicrointerfaces. The DPSV peak current response waslinear with drug concentration in the artificial saliva matrixover the concentration range of 0.05-1 µM (ip ) -8.13(nA µM-1)(concentration) + 0.07 (nA), R ) 0.9929,n ) 7), and the calculated detection limit (3sb) was0.02 µM. These results demonstrate that DPSV atarrays of liquid|liquid microinterfaces is a viable analyticalapproach for pharmaceutical determinations inbiomimetic matrixes. 2009 Journal Article http://hdl.handle.net/20.500.11937/5935 American Chemical Society restricted |
| spellingShingle | Collins, C. Arrigan, Damien Ion-Transfer Voltammetric Determination of the B-Blocker Propranolol in a Physiological Matrix at Silicon Membrane-Based Liquid/Liquid Microinterface Arrays |
| title | Ion-Transfer Voltammetric Determination of the B-Blocker Propranolol in a Physiological Matrix at Silicon Membrane-Based Liquid/Liquid Microinterface Arrays |
| title_full | Ion-Transfer Voltammetric Determination of the B-Blocker Propranolol in a Physiological Matrix at Silicon Membrane-Based Liquid/Liquid Microinterface Arrays |
| title_fullStr | Ion-Transfer Voltammetric Determination of the B-Blocker Propranolol in a Physiological Matrix at Silicon Membrane-Based Liquid/Liquid Microinterface Arrays |
| title_full_unstemmed | Ion-Transfer Voltammetric Determination of the B-Blocker Propranolol in a Physiological Matrix at Silicon Membrane-Based Liquid/Liquid Microinterface Arrays |
| title_short | Ion-Transfer Voltammetric Determination of the B-Blocker Propranolol in a Physiological Matrix at Silicon Membrane-Based Liquid/Liquid Microinterface Arrays |
| title_sort | ion-transfer voltammetric determination of the b-blocker propranolol in a physiological matrix at silicon membrane-based liquid/liquid microinterface arrays |
| url | http://hdl.handle.net/20.500.11937/5935 |