Manganese in drinking water and cognitive abilities and behavior at 10 years of age: A prospective cohort study
Background: Cross-sectional studies have indicated impaired neurodevelopment with elevated drinking water manganese concentrations (W-Mn), but potential susceptible exposure windows are unknown. Objectives: We prospectively evaluated the effects of W-Mn, from fetal life to school age, on children’s...
| Main Authors: | , , , , , |
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| Format: | Journal Article |
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US Department of health Human Sciences National INST of Health Science
2017
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| Online Access: | http://hdl.handle.net/20.500.11937/59324 |
| _version_ | 1848760448663420928 |
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| author | Rahman, S. Kippler, M. Tofail, F. Bölte, Sven Hamadani, J. Vahter, M. |
| author_facet | Rahman, S. Kippler, M. Tofail, F. Bölte, Sven Hamadani, J. Vahter, M. |
| author_sort | Rahman, S. |
| building | Curtin Institutional Repository |
| collection | Online Access |
| description | Background: Cross-sectional studies have indicated impaired neurodevelopment with elevated drinking water manganese concentrations (W-Mn), but potential susceptible exposure windows are unknown. Objectives: We prospectively evaluated the effects of W-Mn, from fetal life to school age, on children’s cognitive abilities and behavior. Methods: We assessed cognitive abilities and behavior in 1,265 ten-year-old children in rural Bangladesh using the Wechsler Intelligence Scale for Children (WISC-IV) and the Strengths and Difficulties Questionnaire (SDQ), respectively. Manganese in drinking water used during pregnancy and by the children at 5 y and 10 y was measured using inductively coupled plasma mass spectrometry. Results: The median W-Mn was 0.20 mg/L (range 0.001-6.6) during pregnancy and 0.34mg/L ( < 0.001-8.7) at 10 y. In multivariable-adjusted linear regression analyses, restricted to children with low arsenic (As) exposure, none of the W-Mn exposures was associated with the children’s cognitive abilities. Stratifying by gender (p for interaction in general < 0.081) showed that prenatal W-Mn (3 mg/L) was positively associated with cognitive ability measures in girls but not in boys. W-Mn at all time points was associated with an increased risk of conduct problems, particularly in boys (range 24-43% per mg/L). At the same time, the prenatal W-Mn was associated with a decreased risk of emotional problems [odds ratio (OR)=0.39 (95% CI: 0.19, 0.82)] in boys. In girls, W-Mn was mainly associated with low prosocial scores [prenatal W-Mn: OR=1.48 (95% CI: 1.06, 1.88)] . Conclusions: Elevated prenatal W-Mn exposure was positively associated with cognitive function in girls, whereas boys appeared to be unaffected. Early life W-Mn exposure appeared to adversely affect children’s behavior. |
| first_indexed | 2025-11-14T10:15:57Z |
| format | Journal Article |
| id | curtin-20.500.11937-59324 |
| institution | Curtin University Malaysia |
| institution_category | Local University |
| last_indexed | 2025-11-14T10:15:57Z |
| publishDate | 2017 |
| publisher | US Department of health Human Sciences National INST of Health Science |
| recordtype | eprints |
| repository_type | Digital Repository |
| spelling | curtin-20.500.11937-593242018-03-29T09:08:38Z Manganese in drinking water and cognitive abilities and behavior at 10 years of age: A prospective cohort study Rahman, S. Kippler, M. Tofail, F. Bölte, Sven Hamadani, J. Vahter, M. Background: Cross-sectional studies have indicated impaired neurodevelopment with elevated drinking water manganese concentrations (W-Mn), but potential susceptible exposure windows are unknown. Objectives: We prospectively evaluated the effects of W-Mn, from fetal life to school age, on children’s cognitive abilities and behavior. Methods: We assessed cognitive abilities and behavior in 1,265 ten-year-old children in rural Bangladesh using the Wechsler Intelligence Scale for Children (WISC-IV) and the Strengths and Difficulties Questionnaire (SDQ), respectively. Manganese in drinking water used during pregnancy and by the children at 5 y and 10 y was measured using inductively coupled plasma mass spectrometry. Results: The median W-Mn was 0.20 mg/L (range 0.001-6.6) during pregnancy and 0.34mg/L ( < 0.001-8.7) at 10 y. In multivariable-adjusted linear regression analyses, restricted to children with low arsenic (As) exposure, none of the W-Mn exposures was associated with the children’s cognitive abilities. Stratifying by gender (p for interaction in general < 0.081) showed that prenatal W-Mn (3 mg/L) was positively associated with cognitive ability measures in girls but not in boys. W-Mn at all time points was associated with an increased risk of conduct problems, particularly in boys (range 24-43% per mg/L). At the same time, the prenatal W-Mn was associated with a decreased risk of emotional problems [odds ratio (OR)=0.39 (95% CI: 0.19, 0.82)] in boys. In girls, W-Mn was mainly associated with low prosocial scores [prenatal W-Mn: OR=1.48 (95% CI: 1.06, 1.88)] . Conclusions: Elevated prenatal W-Mn exposure was positively associated with cognitive function in girls, whereas boys appeared to be unaffected. Early life W-Mn exposure appeared to adversely affect children’s behavior. 2017 Journal Article http://hdl.handle.net/20.500.11937/59324 10.1289/EHP631 US Department of health Human Sciences National INST of Health Science restricted |
| spellingShingle | Rahman, S. Kippler, M. Tofail, F. Bölte, Sven Hamadani, J. Vahter, M. Manganese in drinking water and cognitive abilities and behavior at 10 years of age: A prospective cohort study |
| title | Manganese in drinking water and cognitive abilities and behavior at 10 years of age: A prospective cohort study |
| title_full | Manganese in drinking water and cognitive abilities and behavior at 10 years of age: A prospective cohort study |
| title_fullStr | Manganese in drinking water and cognitive abilities and behavior at 10 years of age: A prospective cohort study |
| title_full_unstemmed | Manganese in drinking water and cognitive abilities and behavior at 10 years of age: A prospective cohort study |
| title_short | Manganese in drinking water and cognitive abilities and behavior at 10 years of age: A prospective cohort study |
| title_sort | manganese in drinking water and cognitive abilities and behavior at 10 years of age: a prospective cohort study |
| url | http://hdl.handle.net/20.500.11937/59324 |