Early developmental regression in autism spectrum disorder: Evidence from an international multiplex sample

The characteristics of early developmental regression (EDR) were investigated in individuals with ASD from affected relative pairs recruited to the International Molecular Genetic Study of Autism Consortium (IMGSAC). Four hundred and fifty-eight individuals with ASD were recruited from 226 IMGSAC fa...

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Main Authors:	Parr, J., Le Couteur, A., Baird, G., Rutter, M., Pickles, A., Fombonne, E., Bailey, A., Wallace, S., Wittemeyer, K., Monaco, A., Barnby, G., Bolton, P., Moore, J., Murin, M., McConachie, H., Berney, T., Docherty, Z., Abbs, S., Ogilvie, C., Warburton, P., Lamb, J., Green, J., Bolton, B., Packer, R., Haracopos, D., Pedersen, L., Isager, T., Brondum-Nielsen, K., Roge, B., Tauber, M., Mantoulan, C., Poustka, F., Bölte, Sven, Feineis-Matthews, S., Rühl, D., Schmötzer, G., Poustka, A., Klauck, S., Tsiantis, J., Papanikolaou, K., Maestrini, E., Van Engeland, H., De Jonge, M., Lord, C., Corsello, C., Cook, E., Salt, J., Guter, S., Leventhal, B., Volkmar, F., Koenig, K.
Format:	Journal Article
Published:	Springer New York LLC 2011
Online Access:	http://hdl.handle.net/20.500.11937/59318

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author	Parr, J. Le Couteur, A. Baird, G. Rutter, M. Pickles, A. Fombonne, E. Bailey, A. Wallace, S. Wittemeyer, K. Monaco, A. Barnby, G. Bolton, P. Moore, J. Murin, M. McConachie, H. Berney, T. Docherty, Z. Abbs, S. Ogilvie, C. Warburton, P. Lamb, J. Green, J. Bolton, B. Packer, R. Haracopos, D. Pedersen, L. Isager, T. Brondum-Nielsen, K. Roge, B. Tauber, M. Mantoulan, C. Poustka, F. Bölte, Sven Feineis-Matthews, S. Rühl, D. Schmötzer, G. Poustka, A. Klauck, S. Tsiantis, J. Papanikolaou, K. Maestrini, E. Van Engeland, H. De Jonge, M. Lord, C. Corsello, C. Cook, E. Salt, J. Guter, S. Leventhal, B. Volkmar, F. Koenig, K.
author_facet	Parr, J. Le Couteur, A. Baird, G. Rutter, M. Pickles, A. Fombonne, E. Bailey, A. Wallace, S. Wittemeyer, K. Monaco, A. Barnby, G. Bolton, P. Moore, J. Murin, M. McConachie, H. Berney, T. Docherty, Z. Abbs, S. Ogilvie, C. Warburton, P. Lamb, J. Green, J. Bolton, B. Packer, R. Haracopos, D. Pedersen, L. Isager, T. Brondum-Nielsen, K. Roge, B. Tauber, M. Mantoulan, C. Poustka, F. Bölte, Sven Feineis-Matthews, S. Rühl, D. Schmötzer, G. Poustka, A. Klauck, S. Tsiantis, J. Papanikolaou, K. Maestrini, E. Van Engeland, H. De Jonge, M. Lord, C. Corsello, C. Cook, E. Salt, J. Guter, S. Leventhal, B. Volkmar, F. Koenig, K.
author_sort	Parr, J.
building	Curtin Institutional Repository
collection	Online Access
description	The characteristics of early developmental regression (EDR) were investigated in individuals with ASD from affected relative pairs recruited to the International Molecular Genetic Study of Autism Consortium (IMGSAC). Four hundred and fifty-eight individuals with ASD were recruited from 226 IMGSAC families. Regression before age 36 months occurred in 23.9% of individuals. The observed concordance rate for EDR within sibling pairs (18.9%) was not significantly above the rate expected under independence (13.5%, p = 0.10). The rate of regression in individuals with ASD from multiplex families was similar to that reported in singleton and epidemiological samples. Regression concordance data were not supportive of a separate familial influence on EDR, other than as a part of autism itself. © Springer Science+Business Media, LLC 2010.
first_indexed	2025-11-14T10:15:55Z
format	Journal Article
id	curtin-20.500.11937-59318
institution	Curtin University Malaysia
institution_category	Local University
last_indexed	2025-11-14T10:15:55Z
publishDate	2011
publisher	Springer New York LLC
recordtype	eprints
repository_type	Digital Repository
spelling	curtin-20.500.11937-593182018-03-05T07:52:57Z Early developmental regression in autism spectrum disorder: Evidence from an international multiplex sample Parr, J. Le Couteur, A. Baird, G. Rutter, M. Pickles, A. Fombonne, E. Bailey, A. Wallace, S. Wittemeyer, K. Monaco, A. Barnby, G. Bolton, P. Moore, J. Murin, M. McConachie, H. Berney, T. Docherty, Z. Abbs, S. Ogilvie, C. Warburton, P. Lamb, J. Green, J. Bolton, B. Packer, R. Haracopos, D. Pedersen, L. Isager, T. Brondum-Nielsen, K. Roge, B. Tauber, M. Mantoulan, C. Poustka, F. Bölte, Sven Feineis-Matthews, S. Rühl, D. Schmötzer, G. Poustka, A. Klauck, S. Tsiantis, J. Papanikolaou, K. Maestrini, E. Van Engeland, H. De Jonge, M. Lord, C. Corsello, C. Cook, E. Salt, J. Guter, S. Leventhal, B. Volkmar, F. Koenig, K. The characteristics of early developmental regression (EDR) were investigated in individuals with ASD from affected relative pairs recruited to the International Molecular Genetic Study of Autism Consortium (IMGSAC). Four hundred and fifty-eight individuals with ASD were recruited from 226 IMGSAC families. Regression before age 36 months occurred in 23.9% of individuals. The observed concordance rate for EDR within sibling pairs (18.9%) was not significantly above the rate expected under independence (13.5%, p = 0.10). The rate of regression in individuals with ASD from multiplex families was similar to that reported in singleton and epidemiological samples. Regression concordance data were not supportive of a separate familial influence on EDR, other than as a part of autism itself. © Springer Science+Business Media, LLC 2010. 2011 Journal Article http://hdl.handle.net/20.500.11937/59318 10.1007/s10803-010-1055-2 Springer New York LLC restricted
spellingShingle	Parr, J. Le Couteur, A. Baird, G. Rutter, M. Pickles, A. Fombonne, E. Bailey, A. Wallace, S. Wittemeyer, K. Monaco, A. Barnby, G. Bolton, P. Moore, J. Murin, M. McConachie, H. Berney, T. Docherty, Z. Abbs, S. Ogilvie, C. Warburton, P. Lamb, J. Green, J. Bolton, B. Packer, R. Haracopos, D. Pedersen, L. Isager, T. Brondum-Nielsen, K. Roge, B. Tauber, M. Mantoulan, C. Poustka, F. Bölte, Sven Feineis-Matthews, S. Rühl, D. Schmötzer, G. Poustka, A. Klauck, S. Tsiantis, J. Papanikolaou, K. Maestrini, E. Van Engeland, H. De Jonge, M. Lord, C. Corsello, C. Cook, E. Salt, J. Guter, S. Leventhal, B. Volkmar, F. Koenig, K. Early developmental regression in autism spectrum disorder: Evidence from an international multiplex sample
title	Early developmental regression in autism spectrum disorder: Evidence from an international multiplex sample
title_full	Early developmental regression in autism spectrum disorder: Evidence from an international multiplex sample
title_fullStr	Early developmental regression in autism spectrum disorder: Evidence from an international multiplex sample
title_full_unstemmed	Early developmental regression in autism spectrum disorder: Evidence from an international multiplex sample
title_short	Early developmental regression in autism spectrum disorder: Evidence from an international multiplex sample
title_sort	early developmental regression in autism spectrum disorder: evidence from an international multiplex sample
url	http://hdl.handle.net/20.500.11937/59318

Early developmental regression in autism spectrum disorder: Evidence from an international multiplex sample

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