Oral insulin delivery: existing barriers and current counter-strategies
Objectives: The chronic and progressive nature of diabetes is usually associated with micro- and macrovascular complications where failure of pancreatic ß-cell function and a general condition of hyperglycaemia is created. One possible factor is failure of the patient to comply with and adhere to th...
| Main Authors: | , , , |
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| Format: | Journal Article |
| Published: |
John Wiley & Sons Ltd.
2017
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| Online Access: | http://hdl.handle.net/20.500.11937/59312 |
| _version_ | 1848760445254500352 |
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| author | Gedawy, A. Martinez, Jorge Al-Salami, Hani Dass, Crispin |
| author_facet | Gedawy, A. Martinez, Jorge Al-Salami, Hani Dass, Crispin |
| author_sort | Gedawy, A. |
| building | Curtin Institutional Repository |
| collection | Online Access |
| description | Objectives: The chronic and progressive nature of diabetes is usually associated with micro- and macrovascular complications where failure of pancreatic ß-cell function and a general condition of hyperglycaemia is created. One possible factor is failure of the patient to comply with and adhere to the prescribed insulin due to the inconvenient administration route. This review summarizes the rationale for oral insulin administration, existing barriers and some counter-strategies trialled. Key Findings: Oral insulin mimics the physiology of endogenous insulin secreted by pancreas. Following the intestinal absorption of oral insulin, it reaches the liver at high concentration via the portal vein. Oral insulin on the other hand has the potential to protect pancreatic ß-cells from autoimmune destruction. Structural modification, targeting a particular tissue/receptor, and the use of innovative pharmaceutical formulations such as nanoparticles represent strategies introduced to improve oral insulin bioavailability. They showed promising results in overcoming the hurdles facing oral insulin delivery, although delivery is far from ideal. Summary: The use of advanced pharmaceutical technologies and further research in particulate carrier system delivery predominantly nanoparticle utilization would offer useful tools in delivering insulin via the oral route which in turn would potentially improve diabetic patient compliance to insulin and the overall management of diabetes. |
| first_indexed | 2025-11-14T10:15:53Z |
| format | Journal Article |
| id | curtin-20.500.11937-59312 |
| institution | Curtin University Malaysia |
| institution_category | Local University |
| last_indexed | 2025-11-14T10:15:53Z |
| publishDate | 2017 |
| publisher | John Wiley & Sons Ltd. |
| recordtype | eprints |
| repository_type | Digital Repository |
| spelling | curtin-20.500.11937-593122018-03-05T07:36:47Z Oral insulin delivery: existing barriers and current counter-strategies Gedawy, A. Martinez, Jorge Al-Salami, Hani Dass, Crispin Objectives: The chronic and progressive nature of diabetes is usually associated with micro- and macrovascular complications where failure of pancreatic ß-cell function and a general condition of hyperglycaemia is created. One possible factor is failure of the patient to comply with and adhere to the prescribed insulin due to the inconvenient administration route. This review summarizes the rationale for oral insulin administration, existing barriers and some counter-strategies trialled. Key Findings: Oral insulin mimics the physiology of endogenous insulin secreted by pancreas. Following the intestinal absorption of oral insulin, it reaches the liver at high concentration via the portal vein. Oral insulin on the other hand has the potential to protect pancreatic ß-cells from autoimmune destruction. Structural modification, targeting a particular tissue/receptor, and the use of innovative pharmaceutical formulations such as nanoparticles represent strategies introduced to improve oral insulin bioavailability. They showed promising results in overcoming the hurdles facing oral insulin delivery, although delivery is far from ideal. Summary: The use of advanced pharmaceutical technologies and further research in particulate carrier system delivery predominantly nanoparticle utilization would offer useful tools in delivering insulin via the oral route which in turn would potentially improve diabetic patient compliance to insulin and the overall management of diabetes. 2017 Journal Article http://hdl.handle.net/20.500.11937/59312 10.1111/jphp.12852 John Wiley & Sons Ltd. unknown |
| spellingShingle | Gedawy, A. Martinez, Jorge Al-Salami, Hani Dass, Crispin Oral insulin delivery: existing barriers and current counter-strategies |
| title | Oral insulin delivery: existing barriers and current counter-strategies |
| title_full | Oral insulin delivery: existing barriers and current counter-strategies |
| title_fullStr | Oral insulin delivery: existing barriers and current counter-strategies |
| title_full_unstemmed | Oral insulin delivery: existing barriers and current counter-strategies |
| title_short | Oral insulin delivery: existing barriers and current counter-strategies |
| title_sort | oral insulin delivery: existing barriers and current counter-strategies |
| url | http://hdl.handle.net/20.500.11937/59312 |