The Protein Corona of PEGylated PGMA-Based Nanoparticles is Preferentially Enriched with Specific Serum Proteins of Varied Biological Function
The composition of the protein corona formed on poly(ethylene glycol)-functionalized (PEGylated) poly(glycidyl methacrylate) (PGMA) nanoparticles (NPs) was qualitatively and quantitatively compared to the protein corona on non-PEGylated PGMA NPs. Despite the reputation of PEGylated NPs for stealth f...
| Main Authors: | , , , , , , |
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| Format: | Journal Article |
| Published: |
American Chemical Society
2017
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| Online Access: | http://purl.org/au-research/grants/nhmrc/1082403 http://hdl.handle.net/20.500.11937/59174 |
| _version_ | 1848760404548780032 |
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| author | Naidu, P. Norret, M. Smith, N. Dunlop, S. Taylor, N. Fitzgerald, Melinda Iyer, K. |
| author_facet | Naidu, P. Norret, M. Smith, N. Dunlop, S. Taylor, N. Fitzgerald, Melinda Iyer, K. |
| author_sort | Naidu, P. |
| building | Curtin Institutional Repository |
| collection | Online Access |
| description | The composition of the protein corona formed on poly(ethylene glycol)-functionalized (PEGylated) poly(glycidyl methacrylate) (PGMA) nanoparticles (NPs) was qualitatively and quantitatively compared to the protein corona on non-PEGylated PGMA NPs. Despite the reputation of PEGylated NPs for stealth functionality, we demonstrate the preferential enrichment of specific serum proteins of varied biological function in the protein corona on PEGylated NPs when compared to non-PEGylated NPs. Additionally, we suggest that the base material of polymeric NPs plays a role in the preferential enrichment of select serum proteins to the hard corona. |
| first_indexed | 2025-11-14T10:15:14Z |
| format | Journal Article |
| id | curtin-20.500.11937-59174 |
| institution | Curtin University Malaysia |
| institution_category | Local University |
| last_indexed | 2025-11-14T10:15:14Z |
| publishDate | 2017 |
| publisher | American Chemical Society |
| recordtype | eprints |
| repository_type | Digital Repository |
| spelling | curtin-20.500.11937-591742018-10-16T05:57:17Z The Protein Corona of PEGylated PGMA-Based Nanoparticles is Preferentially Enriched with Specific Serum Proteins of Varied Biological Function Naidu, P. Norret, M. Smith, N. Dunlop, S. Taylor, N. Fitzgerald, Melinda Iyer, K. The composition of the protein corona formed on poly(ethylene glycol)-functionalized (PEGylated) poly(glycidyl methacrylate) (PGMA) nanoparticles (NPs) was qualitatively and quantitatively compared to the protein corona on non-PEGylated PGMA NPs. Despite the reputation of PEGylated NPs for stealth functionality, we demonstrate the preferential enrichment of specific serum proteins of varied biological function in the protein corona on PEGylated NPs when compared to non-PEGylated NPs. Additionally, we suggest that the base material of polymeric NPs plays a role in the preferential enrichment of select serum proteins to the hard corona. 2017 Journal Article http://hdl.handle.net/20.500.11937/59174 10.1021/acs.langmuir.7b02568 http://purl.org/au-research/grants/nhmrc/1082403 http://purl.org/au-research/grants/nhmrc/1087114 American Chemical Society fulltext |
| spellingShingle | Naidu, P. Norret, M. Smith, N. Dunlop, S. Taylor, N. Fitzgerald, Melinda Iyer, K. The Protein Corona of PEGylated PGMA-Based Nanoparticles is Preferentially Enriched with Specific Serum Proteins of Varied Biological Function |
| title | The Protein Corona of PEGylated PGMA-Based Nanoparticles is Preferentially Enriched with Specific Serum Proteins of Varied Biological Function |
| title_full | The Protein Corona of PEGylated PGMA-Based Nanoparticles is Preferentially Enriched with Specific Serum Proteins of Varied Biological Function |
| title_fullStr | The Protein Corona of PEGylated PGMA-Based Nanoparticles is Preferentially Enriched with Specific Serum Proteins of Varied Biological Function |
| title_full_unstemmed | The Protein Corona of PEGylated PGMA-Based Nanoparticles is Preferentially Enriched with Specific Serum Proteins of Varied Biological Function |
| title_short | The Protein Corona of PEGylated PGMA-Based Nanoparticles is Preferentially Enriched with Specific Serum Proteins of Varied Biological Function |
| title_sort | protein corona of pegylated pgma-based nanoparticles is preferentially enriched with specific serum proteins of varied biological function |
| url | http://purl.org/au-research/grants/nhmrc/1082403 http://purl.org/au-research/grants/nhmrc/1082403 http://hdl.handle.net/20.500.11937/59174 |