The applications of microencapsulated formulation of gliclazide and bile acids in Type-1 diabetes mellitus
Gliclazide is used in Type 2 diabetes (T2D) to stimulate insulin production but it also has beneficial extra-pancreatic effects which make it potentially useful in T1D. In this thesis, gliclazide was formulated with different bile acids, to enhance its effects, and formed microcapsules were examined...
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| Format: | Thesis |
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Curtin University
2017
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| Online Access: | http://hdl.handle.net/20.500.11937/59125 |
| _version_ | 1848760400974184448 |
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| author | Mathavan, Sangeetha |
| author_facet | Mathavan, Sangeetha |
| author_sort | Mathavan, Sangeetha |
| building | Curtin Institutional Repository |
| collection | Online Access |
| description | Gliclazide is used in Type 2 diabetes (T2D) to stimulate insulin production but it also has beneficial extra-pancreatic effects which make it potentially useful in T1D. In this thesis, gliclazide was formulated with different bile acids, to enhance its effects, and formed microcapsules were examined in-vitro and in-vivo. In-vitro examinations of the microcapsules included complete characterization of the microcapsules in terms of interactions between gliclazide and a primary bile acid (chenodeoxycholic acid), a secondary bile acid (taurocholic acid) and a tertiary bile acid (ursodeoxycholic acid), and in-vitro release of gliclazide from microcapsules, while in-vivo examination of the microcapsules included gliclazide absorption and hypoglycemic and antiinflammatory effects in a rat model of T1D. |
| first_indexed | 2025-11-14T10:15:11Z |
| format | Thesis |
| id | curtin-20.500.11937-59125 |
| institution | Curtin University Malaysia |
| institution_category | Local University |
| last_indexed | 2025-11-14T10:15:11Z |
| publishDate | 2017 |
| publisher | Curtin University |
| recordtype | eprints |
| repository_type | Digital Repository |
| spelling | curtin-20.500.11937-591252017-12-06T04:56:55Z The applications of microencapsulated formulation of gliclazide and bile acids in Type-1 diabetes mellitus Mathavan, Sangeetha Gliclazide is used in Type 2 diabetes (T2D) to stimulate insulin production but it also has beneficial extra-pancreatic effects which make it potentially useful in T1D. In this thesis, gliclazide was formulated with different bile acids, to enhance its effects, and formed microcapsules were examined in-vitro and in-vivo. In-vitro examinations of the microcapsules included complete characterization of the microcapsules in terms of interactions between gliclazide and a primary bile acid (chenodeoxycholic acid), a secondary bile acid (taurocholic acid) and a tertiary bile acid (ursodeoxycholic acid), and in-vitro release of gliclazide from microcapsules, while in-vivo examination of the microcapsules included gliclazide absorption and hypoglycemic and antiinflammatory effects in a rat model of T1D. 2017 Thesis http://hdl.handle.net/20.500.11937/59125 Curtin University restricted |
| spellingShingle | Mathavan, Sangeetha The applications of microencapsulated formulation of gliclazide and bile acids in Type-1 diabetes mellitus |
| title | The applications of microencapsulated formulation of gliclazide and bile acids in Type-1 diabetes mellitus |
| title_full | The applications of microencapsulated formulation of gliclazide and bile acids in Type-1 diabetes mellitus |
| title_fullStr | The applications of microencapsulated formulation of gliclazide and bile acids in Type-1 diabetes mellitus |
| title_full_unstemmed | The applications of microencapsulated formulation of gliclazide and bile acids in Type-1 diabetes mellitus |
| title_short | The applications of microencapsulated formulation of gliclazide and bile acids in Type-1 diabetes mellitus |
| title_sort | applications of microencapsulated formulation of gliclazide and bile acids in type-1 diabetes mellitus |
| url | http://hdl.handle.net/20.500.11937/59125 |