The Synthesis and Evaluation of Novel Core-Shell Nanostructured Metal Oxides for Cancer Targeting
This thesis details the synthesis and characterisation of novel silica coated Fe3O4-ZnO core-shell nanostructures for applications in target-specific photodynamic cancer therapy. While the silica shell was outfitted with folic acid for promoting cell specificity, dansyl chloride for fluorescent imag...
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| Format: | Thesis |
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Curtin University
2016
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| Online Access: | http://hdl.handle.net/20.500.11937/59124 |
| _version_ | 1848760400668000256 |
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| author | Patel, Kunal Kamleshkumar |
| author_facet | Patel, Kunal Kamleshkumar |
| author_sort | Patel, Kunal Kamleshkumar |
| building | Curtin Institutional Repository |
| collection | Online Access |
| description | This thesis details the synthesis and characterisation of novel silica coated Fe3O4-ZnO core-shell nanostructures for applications in target-specific photodynamic cancer therapy. While the silica shell was outfitted with folic acid for promoting cell specificity, dansyl chloride for fluorescent imaging and polyethylene glycol for biocompatibility and stability, the photoactive core showed significant in-vitro photo-killing ability. The methods and results established in this thesis provide researchers of cancer therapeutics new insights into nanoparticle design and modification schemes. |
| first_indexed | 2025-11-14T10:15:11Z |
| format | Thesis |
| id | curtin-20.500.11937-59124 |
| institution | Curtin University Malaysia |
| institution_category | Local University |
| last_indexed | 2025-11-14T10:15:11Z |
| publishDate | 2016 |
| publisher | Curtin University |
| recordtype | eprints |
| repository_type | Digital Repository |
| spelling | curtin-20.500.11937-591242017-12-06T03:13:13Z The Synthesis and Evaluation of Novel Core-Shell Nanostructured Metal Oxides for Cancer Targeting Patel, Kunal Kamleshkumar This thesis details the synthesis and characterisation of novel silica coated Fe3O4-ZnO core-shell nanostructures for applications in target-specific photodynamic cancer therapy. While the silica shell was outfitted with folic acid for promoting cell specificity, dansyl chloride for fluorescent imaging and polyethylene glycol for biocompatibility and stability, the photoactive core showed significant in-vitro photo-killing ability. The methods and results established in this thesis provide researchers of cancer therapeutics new insights into nanoparticle design and modification schemes. 2016 Thesis http://hdl.handle.net/20.500.11937/59124 Curtin University fulltext |
| spellingShingle | Patel, Kunal Kamleshkumar The Synthesis and Evaluation of Novel Core-Shell Nanostructured Metal Oxides for Cancer Targeting |
| title | The Synthesis and Evaluation of Novel Core-Shell Nanostructured Metal Oxides for Cancer Targeting |
| title_full | The Synthesis and Evaluation of Novel Core-Shell Nanostructured Metal Oxides for Cancer Targeting |
| title_fullStr | The Synthesis and Evaluation of Novel Core-Shell Nanostructured Metal Oxides for Cancer Targeting |
| title_full_unstemmed | The Synthesis and Evaluation of Novel Core-Shell Nanostructured Metal Oxides for Cancer Targeting |
| title_short | The Synthesis and Evaluation of Novel Core-Shell Nanostructured Metal Oxides for Cancer Targeting |
| title_sort | synthesis and evaluation of novel core-shell nanostructured metal oxides for cancer targeting |
| url | http://hdl.handle.net/20.500.11937/59124 |