Development, evaluation and application of 3D QSAR Pharmacophore model in the discovery of potential human renin inhibitors.

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Development, evaluation and application of 3D QSAR Pharmacophore model in the discovery of potential human renin inhibitors.

Renin has become an attractive target in controlling hypertension because of the high specificity towards its only substrate, angiotensinogen. The conversion of angiotensinogen to angiotensin I is the first and rate-limiting step of renin-angiotensin system and thus designing inhibitors to block thi...

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Bibliographic Details
Main Authors:	John, S., Thangapandian, S., Arooj, Mahreen, Hong, J., Kim, K., Lee, K.
Format:	Journal Article
Published:	2011
Online Access:	http://hdl.handle.net/20.500.11937/5910

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